Invasion of tumor cells through ECM (extracellular matrix) is one of the hallmarks of cancer, yet the process is poorly modeled in vitro, especially in an automated format. We are now offering compound profiling services for information rich, 3D tumor cell invasion assays using our novel iuvo Microchannel 5250 array platform. Designed as an improvement to Boyden chamber assays, our fully automated invasion assay uses microscopic imaging of cell movement through horizontally-oriented, collagen filled microchannels to provide quantitative data on cell motility. The microchannels facilitate post-assay staining, which dramatically increases the information content of the assays.

iuvo 3D ECM Invasion Assay Profiling Service Datasheet (PDF)

Our profiling service offers:

• Quantitative inhibitor potency measurements of 3D cell migration
• Quantitative data of cell number and distance traveled
• Cell health reports for every compound
• On-plate quality control with known inhibitors
• Rapid turnaround: most projects completed within two weeks
• Comprehensive data package including raw image files, distance traveled, titration curves, potency values, and a summary of proliferation and toxicity effects