Here is what you can do with Transcreener:

• Screen for small molecule inhibitors
• Determine enzymatic activity
• Profile inhibitor potency / determine IC₅₀ values
• Measure residence time / off-rate / dissociation of lead molecules with target
• Inhibitor selectivity profiling
• Mechanism of action studies

Transcreener Advantages:

• Universal – Use with virtually any kinase
• Direct detection of nucleotide enzyme products eliminates complex coupling steps that add to assay interference
• The sensitivity of Transcreener enables accurate data, generating Z’ values of greater than 0.7 at substrate conversion levels less than 10%
• Saves you time and development costs by using a single set of reagents for the entire kinase enzyme family
• Your choice of FP, FI, and TR-FRET readouts with certified performance on major multimode readers
• Overnight reagent and signal stability means you get reliable, robust screening data in large automated screens
• Safe, non-radioactive assay method
• Measure enzyme activity in real-time allowing for residence time determination in an HTS format.