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Author: Robyn Perrin

Fighting Infection’s Ghost

Wednesday, 15 June 2016 by Robyn Perrin
Aicardi–Goutières syndrome (AGS) is a rare and brutal genetic condition. Most infants born with the syndrome are asymptomatic at birth, but about 1 in 5 have enlarged spleen and liver, elevated liver enzymes in the blood, decreased platelet level, and abnormal neurological responses. Over the first year of life, things get much worse: episodes of
Transcreener cGAMP cGAS Assay
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  • Published in Emerging Targets
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Viruses take the STING out of innate immunity

Thursday, 09 June 2016 by Robyn Perrin
Viral trespassers leave traces of themselves as they overtake cells. The presence of hallmark viral molecules—called PAMPs, for pathogen-associated molecular patterns—allows innate immune system sensors to detect the trail of viral substances as effectively as Sherlock Holmes in miniature. Some of these sensors, or pattern recognition receptors (PRRs), nose out viral DNA and RNA. When
Transcreener cGAMP cGAS Assay
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  • Published in Emerging Targets
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Digging into Dopamine Signaling: Arginine Methylation Regulates GPCRs

Monday, 25 January 2016 by Robyn Perrin
The neurotransmitter dopamine is one of the most fascinating substances regulating behavior, with both delightful and dark qualities. Affecting a mere 20,000 dopamine-responsive neurons out of 100 billion neurons in the human brain, dopamine nonetheless governs critical aspects of our existence including voluntary movement, psychosis, and addiction. Disrupted dopamine signaling is involved in maladies ranging
AptaFluor SAH Methyltransferase Assaydopamine receptor signalingEPIGEN Methyltransferase AssayG protein-coupled receptorsGPCRmethyltransferasePRMT5
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  • Published in Emerging Targets
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Validation of a GEF Inhibitor in Murine Models of Major Osteolytic Diseases

Tuesday, 22 September 2015 by Robyn Perrin
Healthy bones are strong, but forming healthy bones requires a delicate balance between bone-building osteoblasts and bone-degrading osteoclasts. If the action of osteoclasts prevails and bone resorption exceeds bone deposition, bone-diminishing diseases such as osteoporosis occur. The answer seems simple: target osteoclasts as the enemy. But drugs currently available to rein in excessive osteoclast activity
Transcreener UDP Assay
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  • Published in Emerging Targets
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