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Category: Emerging Targets

The Challenging Search for BTK Inhibitors

Tuesday, 27 December 2022 by Bellbrook Labs
BTK's Involved in Systemic lupus erythematosus
Bruton’s Tyrosine Kinase (BTK) is a 76kDa non-receptor Tec kinase that plays numerous diverse roles in B-cell development, immunity, autoimmunity, infection, and cancer. From stem to stern, it consists of an N-terminal plekstrin homology (PH) domain, a TEC homology (TH) domain, two SRC homology (SH2 and SH3) domains, and a C-terminal kinase domain. Unlike SRC,
Autoimmune DiseaseBTKInnate Immunitykinase assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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SARM1 Forefronts Research into Major Neurological Diseases

Monday, 19 December 2022 by Bellbrook Labs
SARM1 Causes Axonal Death
SARM1 [Sterile alpha & toll/interleukin receptor (TIR) motif-containing protein 1] consists of a N-terminal mitochondrial localization sequence (NLS), an autoinhibitory HEAT/armadillo (ARM) domain, two tandem sterile alpha motif domains (SAMs), and a C-terminal toll/interleukin receptor domain (TIR). It is a human toll like receptor (TLR) adaptor protein. TLR adaptors (MYD88, MAL, TRIF, & TRAM) usually
Innate Immunityneurodegenerative diseaseneurological diseaseneuronal cell deathSARM1
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  • Published in Emerging Targets, Innate Immunity, Neurodegenerative Diseases
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SIRT2 Isoforms in Neurodegenerative Diseases & Cancer

Tuesday, 29 November 2022 by Bellbrook Labs
SIRT2 Affects Neurodegenerative Diseases
Silent information regulator type 2 (Sirtuin 2 or SIRT2) is a highly evolutionarily conserved NAD+ dependent deacetylase. SIRT2 is the only Sirtuin that acts in the cytosol. It expresses in almost all tissues, but most abundantly in the central nervous system. While SIRT2 is classified as a type III histone deacetylase, it is also capable
Innate Immunityneurodegenerative diseaseSIRT2Sirtuin 2
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  • Published in Emerging Targets, HTS Assays, Innate Immunity, Neurodegenerative Diseases
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Can WRN Helicase Inhibitors Treat MSI-H Cancers?

Tuesday, 04 October 2022 by Bellbrook Labs
Patient With WRN Helicase Syndrome
Over 100 years ago, Otto Werner first characterized a recessive autosomal disorder that caused premature, but largely typical, aging in adults, starting by the 3rd decade and resulting in death by the 6th decade via myocardial infarction or cancer. This disease, now known as Werner syndrome, is caused by specific alterations in the 162 KDa
Innate Immunitykinase assayWRN Helicase
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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NSP16 Shows Promise for Anti-Viral Therapeutics

Tuesday, 20 September 2022 by Bellbrook Labs
NSP16 Target for COVID-19 Therapeutics
SARS-CoV-2 virus (Covid-19) possesses one of the largest genomes of any RNA virus. While it naturally encodes structural proteins among its 29 genes, it also produces non-structural proteins that are necessary to perpetuate infection. Non-structural protein 16 (NSP16) is one such protein.1 NSP16 Camouflages Viral mRNA NSP16 is an m7GpppA-specific, S-adenosyl-L-methionine-dependent 2’-O-methyltransferase (2’-O-MTase) that “caps”
AptaFluor SAH Methyltransferase AssayCOVID-19Innate ImmunityNSP16
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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Looking Ahead: POLQ in the Future of Immuno-Oncology

Tuesday, 06 September 2022 by Bellbrook Labs
POLQ Involved in DNA Repair
The most well-known and widely studied mechanisms of double-stranded DNA break (DSB) repairs are homologous recombination (HR) and classical non-homologous end joining (C-NHEJ). HR is almost error-free due to formatting by the homologous sister chromosome. C-NHEJ relies on direct ligation of double-stranded DNA ends and only ever presents errors at the junction points. Recently, a
Innate ImmunityPolQTranscreener ADP Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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Discovering the Emerging Importance of PARG in Immunity

Monday, 08 August 2022 by Bellbrook Labs
PARG in Human Immunity
Poly (ADP-ribose) glycohydrolase (PARG), along with poly (ADP-ribose) polymerase 1 (PARP1) are the principal elements of the DNA damage response (DDR). When single-strand breaks occur in cellular DNA, PARP1 mediates the poly ADP ribosylation of itself and target proteins, such as histones, promoting the decompaction of chromatin and recruiting relevant enzymes to initiate DNA repair.
Innate ImmunityPARGTranscreener ADP Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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Helicases as Powerful Tools in Innate Immunity

Monday, 11 July 2022 by Bellbrook Labs
Helicases Used in Innate Immunity
Helicases are among the largest and most highly conserved families of enzymatic proteins in eukaryotic organisms. These proteins utilize NTP hydrolysis (usually ATP) to drive their recognition, remodeling, and response to target DNA or RNA.1 Nearly every aspect of nucleic acid metabolism is mediated by helicases. DNA helicases function in replication, repair, recombination, transcription, chromosome
DDX41DHX36Helicase AssayTranscreener ADP Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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RAF1 & Immunity: A Future Model For Cancer Research?

Tuesday, 28 June 2022 by Bellbrook Labs
Info book on cancer and RAFK1's relation
RAF1, also known as c-Raf, is a member of the Raf family of ubiquitous serine/threonine kinases that regulate several critical biological processes, such as proliferation, differentiation, apoptosis, and metabolism. It functions as an activator of the mitogen-activated protein kinase (MAPK)/ ERK kinase (MEK) signaling pathway and a key effector of the small G protein Ras.
Innate ImmunityRAF1Transcreener ADP Kinase Assay
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  • Published in Emerging Targets, Innate Immunity
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OAS1: The Cost of Host Defense

Monday, 13 June 2022 by Bellbrook Labs
OAS1 The Cost of Host Defense
OAS1 (Oligoadenylate synthetase 1) is induced by type 1 interferon signaling. It recognizes 18 bp (or longer) double stranded RNA segments from invading viruses in the cytosol and catalyzes the production of 2’-5’ linked oligoadenylate (2-5A) from ATP. The 2-5A then, at the expense of yet more ATP, exclusively activates endoribonclease L (RNase L) by
Innate ImmunityOAS1Transcreener OAS Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity, Products
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Recent Posts

  • SLAS 2023 Conference Exhibitor Announcement

    SLAS 2023 – HTS Assays and Discovery Services

    BellBrook Labs will exhibit and present posters...
  • BTK's Involved in Systemic lupus erythematosus

    The Challenging Search for BTK Inhibitors

    Bruton’s Tyrosine Kinase (BTK) is a 76kDa...
  • SARM1 Causes Axonal Death

    SARM1 Forefronts Research into Major Neurological Diseases

    SARM1 [Sterile alpha & toll/interleukin rec...
  • SIRT2 Affects Neurodegenerative Diseases

    SIRT2 Isoforms in Neurodegenerative Diseases & Cancer

    Silent information regulator type 2 (Sirtuin 2 ...
  • Patient With WRN Helicase Syndrome

    Can WRN Helicase Inhibitors Treat MSI-H Cancers?

    Over 100 years ago, Otto Werner first character...

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