DDX17 as a Dynamic Helicase in Innate Immunity
Tuesday, 28 November 2023
DDX17 (p72/p82) was first detected as a bunyavirus inhibitor. Subsequent characterization revealed that it is an ATP-dependent RNA helicase, belonging to the DEAD-box group of proteins and bearing the signature Asp-Glu-Ala-Asp sequence. The presence of a novel upstream CTG translation start site (in addition to a conventional ATG start site) produces two isoforms: p72 is
- Published in Emerging Targets, HTS Assays, Innate Immunity
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Unpuzzling DNMT3A as a Key Epigenetic Player
Monday, 30 October 2023
DNA methyltransferase 3-alpha (DNMT3A) effects de novo cytosine methylation in embryonic and somatic cells through the transfer of a methyl group from S-Adenosyl-L-methionine (SAM) to the cytosine-C5 position of newly created CpG DNA residues. In somatic cells, 60 to 80% of these structures are methylated at any given time. Nonetheless, clusters of CpG residues (islands)
- Published in Emerging Targets, Epigenetics
METTL3 is a Significant Focus in Cancer Research
Monday, 02 October 2023
Methyltransferase-like 3 (METTL3) is a 70 kDa protein, 580 amino acids in length. It is the principal catalytic agent for most of the N6– methyladenosine (m6A) modifications that occur in eukaryotic cell mRNA. METTL3 typically places methyl adducts at the adenosine in motifs, such as DRACH, RAC, or RRACH. As such, it influences mRNA splicing,
- Published in Emerging Targets, HTS Assays
METTL16: An RNA Methyltransferase That Wears Many Hats
Tuesday, 05 September 2023
Methyltransferase-like protein 16 (METTL16) is a recently characterized human RNA methyltransferase in the class I SAM-methyltransferase family. It methylates adenosine at the N6 position in a consensus sequence on U6 small nuclear RNA (U6 snRNA) and S-adenosylmethionine (SAM) synthetase (MAT2A) pre-mRNA to control the activity of these molecules. By regulating SAM homeostasis in a feedback
- Published in Emerging Targets, Epigenetics
[Webinar] Targeting DNA Damage Repair for Drug Discovery Using the Transcreener ADPR® Assay
Thursday, 04 May 2023
Interested in DNA damage repair pathways for drug discovery? Join us for a live webinar, where Ha Pham, senior scientist at BellBrook Labs, will be sharing her expertise on using the Transcreener ADPR Assay, a biochemical HTS assay, to study enzymes involved in DNA damage repair. She will use CD38 and PARG as target examples
- Published in Emerging Targets, HTS Assays, Innate Immunity