ENPP1 Inhibitors, Assays, and Innate Immunity

ENPP1 Inhibitors Improve Innate Immunity
The human immune response is incredible. Unlike the adaptive immune response, the innate response acts quickly and is considered the first line of defense against pathogens and foreign DNA such as tumor cells. To be effective, the innate immune response relies on several cell types and a multitude of proteins such as interferons (INFs). This
Read more
No Comments

The Contribution of DNA Methyltransferase Inhibitors in Treating Myelodysplastic Syndromes

DNA Methyltransferase Inhibitors for MDS
Myelodysplastic syndromes (MDS) are a broad, complex group of cancers characterized by the inability to form mature, healthy blood cells. There are different types with varying degrees of risk associated, making it difficult to diagnose and treat. Additionally, many patients are symptom-free and at an older age where they are likely to have other life-threatening
Read more
No Comments

Using a CD73 Activity Assay to Study the Adenosine Pathway and Cancer

CD73 Activity Assay to Help Stop Cancer
Tumor Immunosuppression and a CD73 Activity Assay –  To say cancer is complex would be an understatement. From the cause, to treatment, to living with the disease, nothing about it is easy. As one of the leading factors of death worldwide and the burden on families and the healthcare system as a whole, it’s no
Read more
No Comments

How a Tyrosine Kinase Inhibitor Is Giving Hope to Lung Cancer Patients

tyrosine kinase inhibitor lung cancer
According to the American Cancer Society, lung cancer is the leading cause of cancer death each year and accounts for approximately 13% of all new cases. The most common type being non-small cell lung cancer (NSCLC). Although smoking is the biggest contributor, other factors such as genetics and environmental pollutants contribute to lung cancer of
Read more
No Comments

ABC Transporter ATPase Assay Helps Discover MsbA Inhibitors

ABC Transporter ATPase Assay Inhibitor
MsbA Inhibitors Help Fight Against Gram-Negative Bacteria As pathogens continue to wreak havoc on human health, new therapeutics are needed. HTS compatible assays such as the Transcreener ABC Transporter ATPase Assay help pave the way to establish new treatments. Gram-negative bacterial pathogens pose grave dangers in clinical and environmental settings alike. They include foodborne disease
Read more
No Comments

Using a Glycosyltransferase Activity Assay to Study Glycosylation and the Function of GTs

Glycosyltransferase Activity Assay and Lysosomal Storage Disorders
Glycosyltransferase (GT) enzymes are incredibly diverse in their abilities to catalyze the transfer of sugar molecules to protein, carbohydrate, and lipid substrates. GTs have various metabolic and regulatory roles in biology. Glycosyltransferase targets provide different areas of therapeutic potential in a wide array of disease, including cancer, metabolic disorders, and infectious disease. A glycosyltransferase activity
Read more
No Comments

Ubiquitin Ligase Assay: A Handy Tool for Drug Discovery

Ubiquitin Ligase Assay Tool for Drug Discovery
Can one cellular pathway contribute to many different types of disease? Research has shown that Ubiquitination is one such pathway due to its role in the regulation of protein degradation within homeostasis, cell cycle, and DNA repair. It has been established that at least the following diseases are among those affected from alterations in this
Read more
No Comments

Could an Inhibitor of Phosphodiesterase Activity be a Treatment for Alzheimer’s?

As we continue to increase our lifespan, diseases such as Alzheimer’s will subsequently persist to develop. With up to 4.5 million Americans currently affected, there’s a strong desire to find a cure or at the very least some relief from the symptoms.¹   Neurodegeneration derived memory loss is the most common and perhaps the most devastating result
Read more
No Comments

Immuno-Oncology Drug Discovery: A CD39 Activity Assay for a Promising Target

Cancer Cell T Cell CD39 Activity Assay
What comes to mind when you think of immunotherapy? The immune system, with all its complexities, contributes to numerous diseases that affect our society. It’s no wonder scientists scramble to find therapies that will either suppress (suppression immunotherapies) or activate (activation immunotherapies) an immune response. Immunotherapy isn’t only used for autoimmune diseases or infectious disease.
Read more
No Comments

NIH Awards BellBrook Labs Phase II Grant to Develop HTS Assays Targeting the cGAS-STING Pathway for Autoimmune Diseases and Cancer

Autoimmune Disease News
The National Institutes of General Medical Sciences (NIGMS) recently awarded BellBrook Labs a $1 million phase II Small Business Innovative Research (SBIR) grant to develop new assays to detect cyclic GMP-AMP (cGAMP) levels in biological samples. The assays will be used to discover, develop, and monitor new treatments for autoimmune diseases and cancer by targeting
Read more
No Comments