A Search for NLRP3 Inhibitors to Fight Autoimmune Disease

Targeting Innate Immunity With NLRP3 Inhibitors
Can NLRP3 inhibitors help treat autoimmune disease? – The human immune response is complicated and we continue to discover pathways involved that add to the complexity. Different than the adaptive immune response, the innate response acts quickly and is considered the first line of defense against pathogens and foreign DNA. In order to do its
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ST6GAL1 Drug Discovery to Combat Cancer

ST6GAL1 Drug Discovery
The number of cancer hallmarks has increased as the knowledge and understanding of the disease progress. As many of us already know, the basic characteristic is a mutation that causes uncontrollable cell growth causing a tumor. Cancer is truly a multi-step development that enables cells to survive, proliferate and metastasize. Other hallmarks of the disease
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Using Glycogen Synthase Assays in the Quest for Type 2 Diabetes Therapies  

glycogen synthase diabetes
Although millions of Americans are living with diabetes thanks to medical intervention, it still ranks among the top ten causes of death; Type 2 being the most common.¹ Energy producing glucose is maintained so that we can withstand times of fasting as well as feasting. Think about the person that survives weeks in the wilderness
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Finding Inhibitors for a Cancer Target: CDK12 Activity Assays Accelerate the Search

CDK12 Activity Assays Find Inhibitors Cancer Treatment
All systems within our bodies function by means of proteins. When these proteins aren’t made correctly, our body malfunctions.  The short explanation: DNA is at the fabric of forming a functional protein; genes (made of DNA) get transcribed and then translated to become proteins. During this complex process, genes are not always correctly transcribed and
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Using TBK1 Inhibitors to Stop Cancer in Its Tracks

Scientist Working on TBK1 Inhibitors for Cancer Research
TBK1 Inhibitors, Autoimmune Disorders, and Cancer – Inflammation is a crucial step within the immune response, helping our bodies eliminate disease. However, it can also be a burden where misregulation creates a variety of maladies including cancer. As inflammation persists, becoming chronic, the beneficial elements can be lost and disease occurs. It’s not just autoimmune
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ENPP1 Inhibitors, Assays, and Innate Immunity

ENPP1 Inhibitors Improve Innate Immunity
The human immune response is incredible. Unlike the adaptive immune response, the innate response acts quickly and is considered the first line of defense against pathogens and foreign DNA such as tumor cells. To be effective, the innate immune response relies on several cell types and a multitude of proteins such as interferons (INFs). This
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The Contribution of DNA Methyltransferase Inhibitors in Treating Myelodysplastic Syndromes

DNA Methyltransferase Inhibitors for MDS
Myelodysplastic syndromes (MDS) are a broad, complex group of cancers characterized by the inability to form mature, healthy blood cells. There are different types with varying degrees of risk associated, making it difficult to diagnose and treat. Additionally, many patients are symptom-free and at an older age where they are likely to have other life-threatening
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Using a CD73 Activity Assay to Study the Adenosine Pathway and Cancer

CD73 Activity Assay to Help Stop Cancer
Tumor Immunosuppression and a CD73 Activity Assay –  To say cancer is complex would be an understatement. From the cause, to treatment, to living with the disease, nothing about it is easy. As one of the leading factors of death worldwide and the burden on families and the healthcare system as a whole, it’s no
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How a Tyrosine Kinase Inhibitor Is Giving Hope to Lung Cancer Patients

tyrosine kinase inhibitor lung cancer
According to the American Cancer Society, lung cancer is the leading cause of cancer death each year and accounts for approximately 13% of all new cases. The most common type being non-small cell lung cancer (NSCLC). Although smoking is the biggest contributor, other factors such as genetics and environmental pollutants contribute to lung cancer of
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ABC Transporter ATPase Assay Helps Discover MsbA Inhibitors

ABC Transporter ATPase Assay Inhibitor
MsbA Inhibitors Help Fight Against Gram-Negative Bacteria As pathogens continue to wreak havoc on human health, new therapeutics are needed. HTS compatible assays such as the Transcreener ABC Transporter ATPase Assay help pave the way to establish new treatments. Gram-negative bacterial pathogens pose grave dangers in clinical and environmental settings alike. They include foodborne disease
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