The Contribution of DNA Methyltransferase Inhibitors in Treating Myelodysplastic Syndromes
Tuesday, 01 October 2019
Myelodysplastic syndromes (MDS) are a broad, complex group of cancers characterized by the inability to form mature, healthy blood cells. There are different types with varying degrees of risk associated, making it difficult to diagnose and treat. Additionally, many patients are symptom-free and at an older age where they are likely to have other life-threatening
- Published in Emerging Targets, Epigenetics
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Using a CD73 Activity Assay to Study the Adenosine Pathway and Cancer
Wednesday, 11 September 2019
Tumor Immunosuppression and a CD73 Activity Assay – To say cancer is complex would be an understatement. From the cause, to treatment, to living with the disease, nothing about it is easy. As one of the leading factors of death worldwide and the burden on families and the healthcare system as a whole, it’s no
- Published in Emerging Targets
How a Tyrosine Kinase Inhibitor Is Giving Hope to Lung Cancer Patients
Tuesday, 20 August 2019
According to the American Cancer Society, lung cancer is the leading cause of cancer death each year and accounts for approximately 13% of all new cases. The most common type being non-small cell lung cancer (NSCLC). Although smoking is the biggest contributor, other factors such as genetics and environmental pollutants contribute to lung cancer of
- Published in Emerging Targets
Using a Glycosyltransferase Activity Assay to Study Glycosylation and the Function of GTs
Tuesday, 09 July 2019
Glycosyltransferase (GT) enzymes are incredibly diverse in their abilities to catalyze the transfer of sugar molecules to protein, carbohydrate, and lipid substrates. GTs have various metabolic and regulatory roles in biology. Glycosyltransferase targets provide different areas of therapeutic potential in a wide array of disease, including cancer, metabolic disorders, and infectious disease. A glycosyltransferase activity
- Published in Emerging Targets, HTS Assays
Ubiquitin Ligase Assay: A Handy Tool for Drug Discovery
Wednesday, 29 May 2019
Can one cellular pathway contribute to many different types of disease? Research has shown that Ubiquitination is one such pathway due to its role in the regulation of protein degradation within homeostasis, cell cycle, and DNA repair. It has been established that at least the following diseases are among those affected from alterations in this
- Published in Emerging Targets, HTS Assays
Could an Inhibitor of Phosphodiesterase Activity be a Treatment for Alzheimer’s?
Tuesday, 14 May 2019
As we continue to increase our lifespan, diseases such as Alzheimer’s will subsequently persist to develop. With up to 4.5 million Americans currently affected, there’s a strong desire to find a cure or at the very least some relief from the symptoms.¹ Neurodegeneration derived memory loss is the most common and perhaps the most devastating result
- Published in Emerging Targets, HTS Assays
Immuno-Oncology Drug Discovery: A CD39 Activity Assay for a Promising Target
Thursday, 02 May 2019
What comes to mind when you think of immunotherapy? The immune system, with all its complexities, contributes to numerous diseases that affect our society. It’s no wonder scientists scramble to find therapies that will either suppress (suppression immunotherapies) or activate (activation immunotherapies) an immune response. Immunotherapy isn’t only used for autoimmune diseases or infectious disease.
- Published in Emerging Targets, HTS Assays
NIH Awards BellBrook Labs Phase II Grant to Develop HTS Assays Targeting the cGAS-STING Pathway for Autoimmune Diseases and Cancer
Tuesday, 22 May 2018
The National Institutes of General Medical Sciences (NIGMS) recently awarded BellBrook Labs a $1 million phase II Small Business Innovative Research (SBIR) grant to develop new assays to detect cyclic GMP-AMP (cGAMP) levels in biological samples. The assays will be used to discover, develop, and monitor new treatments for autoimmune diseases and cancer by targeting
- Published in Company, Emerging Targets, News