Battling Autoimmune Disorders Using JAK1 Inhibitors

JAK1 Inhibitors for Autoimmune Disease
Could specific JAK1 inhibitors lead to better treatments for autoimmune disease? – The human immune response is complex with numerous cellular pathways playing a role. And, when an abnormal immune response results from one’s own body, known as an autoimmune disorder – it adds to the complexity. While we often think of celiac disease, inflammatory
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Researchers Validate Hsp70 Activity with the Transcreener ATPase Assay

Researchers Studying Hsp70 Activity
Newly expressed human Hsp70 activity now being studied –  Heat shock protein 70 (Hsp70) is known for its upregulation during times of stress in order to maintain homeostasis. Like other heat shock proteins, Hsp70 is a chaperone protein that assists other proteins in correctly folding to become fully active molecules.  It binds to damaged, misfolded,
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New Transcreener UDP2 Assay with a Fluorescence Intensity Readout

Transcreener Glycosyltransferase Assay Blog
BellBrook Labs scientists have developed a new universal UDP detection assay for the measurement of Glycosyltransferase activity.  The Transcreener UDP2 FI Assay extends the Transcreener platform for UDP detection by utilizing a simple fluorescence intensity (FI) output. It can be used on fluorescence readers typically found in academic and therapeutic research laboratories, as well as
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FUT7, Inflammation, and Fucosyltransferase Assays

FUT7 Fucosyltransferase Assays and Chronic Inflammation
Inflammation is a necessary step involved in the immune response, allowing our bodies to fight and eliminate disease, allergies, and injuries. The inflammatory response recruits several mediators to aid in the destruction of whatever pathogen caused the response in the first place. Cells such as leucocytes, eosinophils, and neutrophils get recruited to the site in
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Fluorescence Polarization Assays for Drug Discovery

FP Assays
Fluorescence polarization assays (FP assays) are used in a variety of ways.  From uncovering molecules in solution, to monitoring drug levels in clinical settings, and are enabling in drug discovery. These binding assays have been used to gain knowledge of molecular interactions, enzymatic activity, and nucleic acid hybridization. Moreover, scientists use FP to study small
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TR-FRET Assays In Drug Discovery

TR-FRET Assays
Förster resonance energy transfer (FRET) technology and TR-FRET assays are used in laboratories globally for a variety of applications ranging from disease detection, to drug discovery, to monitoring genetic differences between individuals and populations. The brilliance of this technology is due to the sensitivity provided by the spectral overlap and the proximity of the acceptor
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ST6GAL1 Drug Discovery to Combat Cancer

ST6GAL1 Drug Discovery
The number of cancer hallmarks has increased as the knowledge and understanding of the disease progress. As many of us already know, the basic characteristic is a mutation that causes uncontrollable cell growth causing a tumor. Cancer is truly a multi-step development that enables cells to survive, proliferate and metastasize. Other hallmarks of the disease
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Using Glycogen Synthase Assays in the Quest for Type 2 Diabetes Therapies  

glycogen synthase diabetes
Although millions of Americans are living with diabetes thanks to medical intervention, it still ranks among the top ten causes of death; Type 2 being the most common.¹ Energy producing glucose is maintained so that we can withstand times of fasting as well as feasting. Think about the person that survives weeks in the wilderness
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Finding Inhibitors for a Cancer Target: CDK12 Activity Assays Accelerate the Search

CDK12 Activity Assays Find Inhibitors Cancer Treatment
All systems within our bodies function by means of proteins. When these proteins aren’t made correctly, our body malfunctions.  The short explanation: DNA is at the fabric of forming a functional protein; genes (made of DNA) get transcribed and then translated to become proteins. During this complex process, genes are not always correctly transcribed and
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BellBrook Labs Launches Transcreener cGAS Activity Assay to Accelerate Drug Discovery

New Transcreener cGAS Assay
The new Transcreener cGAMP cGAS Assay directly measures the product cGAMP, in a cGAS enzymatic reaction allowing researchers to screen vast compound libraries for novel modulators. The assay will be used to discover and develop new treatments for autoimmune diseases and cancer by targeting the cGAS-STING pathway. Madison, WI – Researchers at BellBrook Labs have
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