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Category: HTS Assays

Small GTPase Modulation: GDP Assays to Accelerate Discovery

Wednesday, 24 March 2021 by Bellbrook Labs
Small GTPase Modulation
Cancer is complex, which makes determining the culprit as well as individual treatment extremely challenging. A variety of cancer types exist with a multitude of contributors. As the second leading cause of death in the US, cancer has been a target scientists have been battling for decades. When DNA is damaged or mutations occur, cells
Small GTPaseTranscreener GDP Assay
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Accelerating Discovery of Kinase Inhibitors Using an ADP Assay

Tuesday, 23 February 2021 by Bellbrook Labs
Researcher Using An ADP Assay
An ADP assay can be used to study the activity of enzymes that phosphorylate substrates leading to signaling events in the body. One of a variety of post-translational modifications, protein phosphorylation regulates a diverse group of cellular functions. In cancer, abnormal phosphorylation events often play a role in proliferation, survival, motility, metabolism, and angiogenesis.1 PI3K
adp assayTranscreener ADP ATPase AssayTranscreener ADP Kinase Assay
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New Publication by the Scientists at BellBrook Labs – Development of a High-Throughput Assay to Identify Inhibitors of ENPP1

Thursday, 11 February 2021 by Bellbrook Labs
Inhibitors of ENPP1 SLAS Discovery
BellBrook scientist Meera Kumar and Robert Lowery were recently published in SLAS Discovery for their work entitled Development of a High-Throughput Assay to Identify Inhibitors of ENPP1. Ectonucleotide pyrophosphatase/phosphodiesterase 1 or ENNP1 has recently become a target for cancer immunotherapy. ENNP1 hydrolyzes nucleotides such as cGAMP and ATP. Cytosolic DNA is a trigger for the
ENPP1 AssayTranscreener AMP/GMP Assay
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  • Published in Emerging Targets, HTS Assays, News
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Using a Universal GMP Assay for PDE Research

Thursday, 28 January 2021 by Bellbrook Labs
GMP Assay for PDE Inhibitor Discovery
A universal GMP assay to aid in PDE research and potential COVID-19 disruption. – Phosphodiesterase enzymes (PDEs) modulate pathways throughout the body. Since unregulated PDEs contribute to disease in many cases, it makes sense therapies that inhibit these enzymes have the potential to treat several different ailments. These include cardiovascular and respiratory issues, diabetes, fibrotic
gmp assayPDE InhibitorsPhosphodiesterase AssayTranscreener AMP/GMP Assay
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Battling Autoimmune Disorders Using JAK1 Inhibitors

Wednesday, 12 August 2020 by Bellbrook Labs
JAK1 Inhibitors for Autoimmune Disease
Could specific JAK1 inhibitors lead to better treatments for autoimmune disease? – The human immune response is complex with numerous cellular pathways playing a role. And, when an abnormal immune response results from one’s own body, known as an autoimmune disorder – it adds to the complexity. While we often think of celiac disease, inflammatory
Autoimmune DiseaseInnate ImmunityJAK1 InhibitorsTranscreener ADP Kinase Assay
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Researchers Validate Hsp70 Activity with the Transcreener ATPase Assay

Wednesday, 24 June 2020 by Bellbrook Labs
Researchers Studying Hsp70 Activity
Newly expressed human Hsp70 activity now being studied –  Heat shock protein 70 (Hsp70) is known for its upregulation during times of stress in order to maintain homeostasis. Like other heat shock proteins, Hsp70 is a chaperone protein that assists other proteins in correctly folding to become fully active molecules.  It binds to damaged, misfolded,
Hsp70 AssayTranscreener ADP ATPase Assay
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New Transcreener UDP2 Assay with a Fluorescence Intensity Readout

Friday, 29 May 2020 by Bellbrook Labs
Transcreener Glycosyltransferase Assay Blog
BellBrook Labs scientists have developed a new universal UDP detection assay for the measurement of Glycosyltransferase activity.  The Transcreener UDP2 FI Assay extends the Transcreener platform for UDP detection by utilizing a simple fluorescence intensity (FI) output. It can be used on fluorescence readers typically found in academic and therapeutic research laboratories, as well as
Glycosyltransferase Activity AssayTranscreener UDP Assay
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FUT7, Inflammation, and Fucosyltransferase Assays

Wednesday, 01 April 2020 by Bellbrook Labs
FUT7 Fucosyltransferase Assays and Chronic Inflammation
Inflammation is a necessary step involved in the immune response, allowing our bodies to fight and eliminate disease, allergies, and injuries. The inflammatory response recruits several mediators to aid in the destruction of whatever pathogen caused the response in the first place. Cells such as leucocytes, eosinophils, and neutrophils get recruited to the site in
Fucosyltransferase AssaysFUT7Transcreener GDP Assay
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Fluorescence Polarization Assays for Drug Discovery

Friday, 06 March 2020 by Bellbrook Labs
FP Assays
Fluorescence polarization assays (FP assays) are used in a variety of ways.  From uncovering molecules in solution, to monitoring drug levels in clinical settings, and are enabling in drug discovery. These binding assays have been used to gain knowledge of molecular interactions, enzymatic activity, and nucleic acid hybridization. Moreover, scientists use FP to study small
Fluorescence PolarizationFP Assays
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TR-FRET Assays In Drug Discovery

Thursday, 06 February 2020 by Bellbrook Labs
TR-FRET Assays
Förster resonance energy transfer (FRET) technology and TR-FRET assays are used in laboratories globally for a variety of applications ranging from disease detection, to drug discovery, to monitoring genetic differences between individuals and populations. The brilliance of this technology is due to the sensitivity provided by the spectral overlap and the proximity of the acceptor
TR-FRET AssaysTranscreener ADP Kinase Assay
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Recent Posts

  • Small GTPase Modulation

    Small GTPase Modulation: GDP Assays to Accelerate Discovery

    Cancer is complex, which makes determining the ...
  • TREX1 Press Release Graphic

    BellBrook Labs Receives NIH Funding for Novel Approach to Stimulating Antitumor Immunity

    The National Cancer Institute (NCI) recently aw...
  • Researcher Using An ADP Assay

    Accelerating Discovery of Kinase Inhibitors Using an ADP Assay

    An ADP assay can be used to study the activity ...
  • Inhibitors of ENPP1 SLAS Discovery

    New Publication by the Scientists at BellBrook Labs – Development of a High-Throughput Assay to Identify Inhibitors of ENPP1

    BellBrook scientist Meera Kumar and Robert Lowe...
  • GMP Assay for PDE Inhibitor Discovery

    Using a Universal GMP Assay for PDE Research

    A universal GMP assay to aid in PDE research an...

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