Researchers Employ GTPase Assay to Investigate Rab Proteins

Scientist Using a GTPase Assay
Measuring Rab interaction with a GTPase Assay – GTPases are in the limelight in biology and drug discovery because of their role in a wide range of cellular processes and functions.  They are highly conserved regulatory proteins involved in such diverse roles as signal transduction, protein biosynthesis, cell adhesion, membrane remodeling and trafficking, cytoskeletal reorganization,
Read more
No Comments

How A PDE Activity Assay Might Help Find New Treatments for Individuals Suffering from Heart Disease

PDE Activity Assay Heart Disease
Heart Disease: The Role of PDEs and a PDE Activity Assay Heart disease is often misunderstood due to confusion with terminology and the different types of heart disease that exist. While a heart attack can occur quickly, heart failure is a slower progression where the heart weakens over time. One thing is certain; heart disease
Read more
No Comments

High Throughput Screening Assays for Drug Discovery

High Throughput Screening Assays for Drug Discovery
The world of drug discovery is exciting, yet challenging. High throughput screening assays (HTS Assays) have changed scientific research and biological testing, allowing for greater efficiency and lower costs.  This is just one case where automation has paid off. Just ask the scientists that aren’t doing repetitive pipetting, doctors getting faster testing results, or patients
Read more
No Comments

ABC Transporter ATPase Assay Helps Discover MsbA Inhibitors

ABC Transporter ATPase Assay Inhibitor
MsbA Inhibitors Help Fight Against Gram-Negative Bacteria As pathogens continue to wreak havoc on human health, new therapeutics are needed. HTS compatible assays such as the Transcreener ABC Transporter ATPase Assay help pave the way to establish new treatments. Gram-negative bacterial pathogens pose grave dangers in clinical and environmental settings alike. They include foodborne disease
Read more
No Comments

Using a Glycosyltransferase Activity Assay to Study Glycosylation and the Function of GTs

Glycosyltransferase Activity Assay and Lysosomal Storage Disorders
Glycosyltransferase (GT) enzymes are incredibly diverse in their abilities to catalyze the transfer of sugar molecules to protein, carbohydrate, and lipid substrates. GTs have various metabolic and regulatory roles in biology. Glycosyltransferase targets provide different areas of therapeutic potential in a wide array of disease, including cancer, metabolic disorders, and infectious disease. A glycosyltransferase activity
Read more
No Comments

Novartis Uses Lipid Kinase Assay in a Quest for a PI4K Inhibitor

Lipid Kinase Assay PI4K Inhibitor
Did you know that diarrhea is the second leading cause of death globally among children under the age of 5?1 Perhaps you have heard of one of the many diarrheal diseases such as cryptosporidiosis caused by a parasite called Cryptosporidium. Many people in the US might associate swimming pools with outbreaks of cryptosporidiosis due to
Read more
No Comments

One Way to Accelerate Biochemical Assay Development

Biochemical Assay Development
In vitro biochemical assay development can be a long and expensive process, consuming months and thousands of dollars.1 Finding an off-the-shelf solution that’s been proven in drug discovery can help remove some of the painstaking labor required for enzymatic assay development. While there is a wide range of biochemical assays for high throughput screening commercially
Read more
No Comments

Ubiquitin Ligase Assay: A Handy Tool for Drug Discovery

Ubiquitin Ligase Assay Tool for Drug Discovery
Can one cellular pathway contribute to many different types of disease? Research has shown that Ubiquitination is one such pathway due to its role in the regulation of protein degradation within homeostasis, cell cycle, and DNA repair. It has been established that at least the following diseases are among those affected from alterations in this
Read more
No Comments

Could an Inhibitor of Phosphodiesterase Activity be a Treatment for Alzheimer’s?

As we continue to increase our lifespan, diseases such as Alzheimer’s will subsequently persist to develop. With up to 4.5 million Americans currently affected, there’s a strong desire to find a cure or at the very least some relief from the symptoms.¹   Neurodegeneration derived memory loss is the most common and perhaps the most devastating result
Read more
No Comments

Immuno-Oncology Drug Discovery: A CD39 Activity Assay for a Promising Target

Cancer Cell T Cell CD39 Activity Assay
What comes to mind when you think of immunotherapy? The immune system, with all its complexities, contributes to numerous diseases that affect our society. It’s no wonder scientists scramble to find therapies that will either suppress (suppression immunotherapies) or activate (activation immunotherapies) an immune response. Immunotherapy isn’t only used for autoimmune diseases or infectious disease.
Read more
No Comments