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Category: HTS Assays

The Role ALPK1 in Health and Disease

Thursday, 12 May 2022 by Bellbrook Labs
Scientist Studying ALKPK1
ALPK1 (Alpha Kinase 1) is an atypical serine/threonine-protein kinase that specifically detects and binds the pathogen-associated pattern metabolites (PAMPs), ADP-beta-D-manno-heptose (Beta-ADP-Heptose) or D-glycero-beta-D-manno-heptose 1,7-bisphosphate (HBP). These metabolic precursors of lipopolysaccharide (LPS) biosynthesis are present in all Gram-negative and some Gram-positive bacteria.  This interaction stimulates ALPK1 to phosphorylate and activate TIFA, initiating an innate immune response
ALPK1Kinase Assay Kit
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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Resolving the Many Roles of DHX36

Wednesday, 27 April 2022 by Bellbrook Labs
DHX36 RNA Helicase Unwinds G4 RNA Structures
While most researchers are familiar with canonical DNA structures, primarily B (but also even A or Z) DNA, an even more exotic form exerts a vast influence over nearly every aspect of nucleic acid function. In both DNA and RNA, tracts of guanine with at least four consecutive members can self-associate via Hoogsten base pairing
DHX36Helicase AssayTranscreener ADP Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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MAPK1, An Elusive Regulator of Innate Immunity

Wednesday, 23 February 2022 by Bellbrook Labs
Researcher working on MAPK1 pathway
Mitogen-Activated Protein Kinases (MAPKs) and MAPK Signaling Cascade Mitogen-activated protein kinases (MAPKs) are Ser/Thr kinases involved in converting extracellular signals to a large spectrum of fundamental cellular processes such as apoptosis, cell division, metabolism survival, etc. This signaling cascade is known as the MAPK pathway. MAPKs are highly conserved among eukaryotes, which mirrors its indispensable
Lead Discovery ServicesMAPK1Transcreener ADP Kinase Assay
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  • Published in HTS Assays, Innate Immunity
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The Double-Edged Sword in Cancer Pathogenesis – JNK1

Wednesday, 03 November 2021 by Bellbrook Labs
JNK1 And Cancer Pathogenesis
Properties and Function of JNK1 c-Jun N-terminal kinase 1 (JNK1), also commonly known as Mitogen-Activated Protein Kinase 8 (MAPK8), is a member of the JNK subgroup of MAP kinases. JNK1 is encoded by the MAPK8 gene. MAP kinases form a superfamily of protein kinases that function by phosphorylating various protein substrates, including transcription factors, which
Innate ImmunityJNK1MAPK8Transcreener ADP Kinase Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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Webinar: Targeting Kinases Involved in the Innate Immune Response

Wednesday, 13 October 2021 by Bellbrook Labs
Abstract: Clinical trials continue to determine whether therapeutic modulation of kinases can be used to suppress the immune system in autoimmune diseases or stimulate for antiviral and cancer immunotherapy. The discovery and characterization of small molecule modulators have aided these efforts. The Transcreener ADP² Kinase Assay meets this need as it relies on direct ADP
Innate Immunitykinase assayTranscreener ADP Kinase Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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B4GalT1 – A Druggable Target for the Treatment of Glioblastoma

Tuesday, 21 September 2021 by Bellbrook Labs
B4GalT1 A Target to Stop Glioblastoma
Multi-faceted Properties of B4GalT1 Beta-1,4-Galactosyltransferase 1 (B4GalT1) belongs to the galactosyltransferase (GalT) family of enzymes that transfer galactose from uridine-diphosphate-α-D-galactose (UDP-Gal) to an acceptor sugar molecule. B4GalT1 is a critical enzyme in galactose metabolism. One of the first GalT to be characterized biochemically, B4GalT1, was also involved in lactose production by interacting with α-lactalbumin during
B4GalT1 AssayGlioblastoma ResearchTranscreener UDP Assay
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  • Published in Emerging Targets, HTS Assays
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Exploring the Use of NUDT5 Inhibitors to Treat Breast Cancer

Monday, 23 August 2021 by Bellbrook Labs
malignant adenocarcinoma could be treated by NUDT5 Inhibitors
NUDT5 is found to be overexpressed in certain cancers in humans Could NUDT5 inhibitors lead to new cancer treatments? NUDIX hydrolases are a superfamily of enzymes are found in all classes of organisms and are responsible for hydrolyzing modified nucleoside diphosphates. One of the most well-studied NUDIX hydrolases is NUDT1 (also known as MTH1); it
NUDIX 5 AssayNUDT5 AssayTranscreener AMP/GMP Assay
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  • Published in Emerging Targets, HTS Assays, Products
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The Role of CD38 Activity in the Impaired Immune Response

Tuesday, 10 August 2021 by Bellbrook Labs
Scientist Working on CD38 Discovery
Cluster of differentiation 38 (CD38) is a multifaceted protein contributing to immune response, cell adhesion, and signal transduction. Furthermore, it plays a vital role in calcium signaling, which is necessary for further cell signaling. Calcium acts as a second messenger regulating muscle contraction, cell growth, fertilization, and cellular motility, to name a few areas of
CD38 AssayTranscreener AMP/GMP Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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NSP13 Inhibitors for the Potential Treatment of COVID-19

Monday, 14 June 2021 by Bellbrook Labs
NSP13 Inhibitors as COVID-19 Treatments
Could NSP13 be the target to help treat some respiratory infections such as SARS-CoV-2? Respiratory diseases caused by coronaviruses (CoVs) vary in symptoms, severity, and risk. Typically, symptoms are mild and known as the common cold, while others are more severe and lead to pneumonia or bronchitis, chest pains, and possibly death. SARS-CoV and MERS-CoV
Helicase AssayNSP13 InhibitorsTranscreener ADP ATPase Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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Using a PKR Inhibitor Assay in the Fight Against Viruses

Tuesday, 01 June 2021 by Bellbrook Labs
PKR Inhibitor Blog
Can a novel PKR inhibitor help lead to new treatments for viral infections? –  While the human immune response is astounding and works hard to keep us alive in the face of the many germs we encounter daily, it is exceedingly complex. Unlike the adaptive immune response, the innate response acts quickly. It is considered
kinase assayPKR InhibitorTranscreener ADP Kinase Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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Recent Posts

  • Scientist Studying ALKPK1

    The Role ALPK1 in Health and Disease

    ALPK1 (Alpha Kinase 1) is an atypical serine/th...
  • DHX36 RNA Helicase Unwinds G4 RNA Structures

    Resolving the Many Roles of DHX36

    While most researchers are familiar with canoni...
  • Researcher Studying MAPK14

    MAPK14 in Context

    MAPK14 (or p38 alpha or SAPK2a) is a proline-di...
  • PRMT5 Role with Macrophages

    PRMT5 is Innately Interesting

    PRMT5 is a type II arginine methyltransferase t...
  • IRE1 Proteins in ER

    The Multifaceted Roles of IRE1 Are Unfolding

    IRE1 (Inositol-Requiring Enzyme 1) is one of th...

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