• Assay Selection Tool

BellBrook Labs

  • Products
    • Transcreener® HTS Assay Kits
      • Transcreener® ADP² Kinase Assay Kits
        • Transcreener® ADP2 Assay Kit – FP Readout
        • Transcreener® ADP2 Assay Kit – FI Readout
        • Transcreener® ADP2 Assay Kit – TR-FRET Readout
      • Transcreener® ADO CD73 Assay Kit
      • Transcreener® ADPR Assay Kit
      • Transcreener® AMP²/GMP² Phosphodiesterase Assay Kits
        • Transcreener® AMP2/GMP2 FP Assay
        • Transcreener® AMP2/GMP2 Assay Kit – TR-FRET Readout
      • Transcreener® cGAMP cGAS Assay Kits
        • Transcreener® cGAMP Assay Kit – FP Readout
        • Transcreener® cGAMP Assay Kit – TR-FRET Readout
      • Transcreener dAMP Exonuclease Assay Kit
      • Transcreener® EPIGEN SAH Methyltransferase Assay Kit
      • Transcreener® GDP GTPase Assay Kits
        • Transcreener® GDP Assay Kit – FP Readout
        • Transcreener® GDP Assay Kit – FI Readout
        • Transcreener® GDP Assay Kit – TR-FRET Readout
      • Transcreener® UDP² Glycosyltransferase Assay Kits
        • Transcreener® UDP2 Assay Kit – FP Readout
        • Transcreener® UDP2 Assay Kit – FI Readout
        • Transcreener® UDP2 Assay Kit – TR-FRET Readout
      • Transcreener® 2-5A OAS Assay Kit
    • AptaFluor® HTS Assay Kits
      • AptaFluor® SAH Methyltransferase Assay Kit
    • Enzyme Assay Systems
      • CD38 Assay System
      • PARG Assay System
      • TREX1 Assay System
      • WRN Helicase Assay System
    • Recombinant Enzymes
      • Human CD38 Enzyme
      • Human cGAS Enzyme
      • Mouse cGAS Enzyme
      • Human DDX3 Enzyme
      • Human OAS1 Enzyme
      • Human PARG Enzyme
      • Human TREX1 Enzyme
      • Human WRN Helicase Enzyme
    • Assay Plates
    • Ordering Information
  • Services
    • Assay Development Services
    • Lead Discovery Services
    • GTPase Profiling Services
    • ATPase Profiling Services
  • Assays by Target
    • Kinase Assays
      • ADK Assays – Application
      • AMPK Assays – Application
      • IKK-beta Assays – Application
      • IRAK4 Assays – Application
      • JAK1 Assays – Application
      • JAK3 Assays – Application
      • MAPK8 Assays – Application
      • PKR Assays – Application
      • RIPK1 Assays – Application
      • RIPK2 Assays – Application
      • TBK1 Assays – Application
    • GTPase Assays
      • GAP Assays – Application
      • GEF Assays – Application
      • KRAS Assays – Application
      • HRAS Assays – Application
      • NRAS Assays – Application
      • RRAS Assays – Application
      • Rac1 Assays – Application
      • RhoA Assays – Application
      • RhoC Assays – Application
      • Cdc42 Assays – Application
      • Ran Assays – Application
    • Methyltransferase Assays
      • EZH2 Assays – Application
      • G9a Assays – Application
      • METTL3/METTL14 Assays – Application
      • SET7/9 Assays – Application
      • SET8 Assays – Application
      • PRMT1 Assays – Application
      • PRMT3 Assays – Application
      • PRMT4 Assays – Application
      • PRMT5 Assays – Application
    • STING Pathway Assays
      • cGAS Assay Kits
      • ENPP1 Assays – Application
      • TREX1 Assay System
      • IKK-beta Assays – Application
      • TBK1 Assays – Application
    • Nucleotidase Assays
      • CD38 Assay System
      • CD39 Assays – Application
      • CD73 Activity Assay Kits
      • PARG Assay System
    • Helicase / ATPase Assays
      • DDX3 Assays – Application
      • NSP13 Assays – Application
      • p97 Assays – Application
      • Ketohexokinase Assays – Application
      • WRN Helicase Assay System
    • Glycosyltransferase Assays
      • Toxin B Assays – Application
      • GALNT2 Assays – Application
      • GALNT3 Assays – Application
      • BGalT1 Assays – Application
    • Phosphodiesterase Assays
      • PDE3 Assays – Application
      • PDE4 Assays – Application
      • PDE5 Assays – Application
      • PDE7 Assays – Application
    • Ligase and Synthetase Assays
      • SUMO E1 Assays – Application
      • Acetyl CoA Synthetase Assays – Application
    • Exonuclease Assays
      • TREX1 Assay System
      • WRN Exonuclease Assays – Application
    • OAS Assays
      • OAS1 Assay Kits
    • Other Enzyme Assays
      • NUDT5 Assays – Application
  • Resources
    • Technical Manuals
    • Instrument Compatibility
    • Application Notes
    • Posters and Presentations
    • Publications
    • Transcreener® FAQ’s
    • Guides
      • Residence Time Guide
      • Hit Prioritization Guide
      • Kinases in Innate Immunity
      • DNA Damage Response and Innate Immunity
    • Technical Support
  • Company
    • President’s Message
    • International Distributors
    • Careers
    • Downloads
    • Contact Us
  • Blog
  • MY CART
    No products in cart.

Category: HTS Assays

Looking Ahead: POLQ in the Future of Immuno-Oncology

Tuesday, 06 September 2022 by Bellbrook Labs
POLQ Involved in DNA Repair
The most well-known and widely studied mechanisms of double-stranded DNA break (DSB) repairs are homologous recombination (HR) and classical non-homologous end joining (C-NHEJ). HR is almost error-free due to formatting by the homologous sister chromosome. C-NHEJ relies on direct ligation of double-stranded DNA ends and only ever presents errors at the junction points. Recently, a
Innate ImmunityPolQTranscreener ADP Assay
Read more
  • Published in Emerging Targets, HTS Assays, Innate Immunity
No Comments

Discovering the Emerging Importance of PARG in Immunity

Monday, 08 August 2022 by Bellbrook Labs
PARG in Human Immunity
Poly (ADP-ribose) glycohydrolase (PARG), along with poly (ADP-ribose) polymerase 1 (PARP1) are the principal elements of the DNA damage response (DDR). When single-strand breaks occur in cellular DNA, PARP1 mediates the poly ADP ribosylation of itself and target proteins, such as histones, promoting the decompaction of chromatin and recruiting relevant enzymes to initiate DNA repair.
Innate ImmunityPARGTranscreener ADP Assay
Read more
  • Published in Emerging Targets, HTS Assays, Innate Immunity
No Comments

Helicases as Powerful Tools in Innate Immunity

Monday, 11 July 2022 by Bellbrook Labs
Helicases Used in Innate Immunity
Helicases are among the largest and most highly conserved families of enzymatic proteins in eukaryotic organisms. These proteins utilize NTP hydrolysis (usually ATP) to drive their recognition, remodeling, and response to target DNA or RNA.1 Nearly every aspect of nucleic acid metabolism is mediated by helicases. DNA helicases function in replication, repair, recombination, transcription, chromosome
DDX41DHX36Helicase AssayTranscreener ADP Assay
Read more
  • Published in Emerging Targets, HTS Assays, Innate Immunity
No Comments

OAS1: The Cost of Host Defense

Monday, 13 June 2022 by Bellbrook Labs
OAS1 The Cost of Host Defense
OAS1 (Oligoadenylate synthetase 1) is induced by type 1 interferon signaling. It recognizes 18 bp (or longer) double stranded RNA segments from invading viruses in the cytosol and catalyzes the production of 2’-5’ linked oligoadenylate (2-5A) from ATP. The 2-5A then, at the expense of yet more ATP, exclusively activates endoribonclease L (RNase L) by
Innate ImmunityOAS1Transcreener OAS Assay
Read more
  • Published in Emerging Targets, HTS Assays, Innate Immunity, Products
No Comments

DDX41 as a Sensor, Suppressor, and Modulator

Thursday, 26 May 2022 by Bellbrook Labs
Scientist Studying DDX41
DDX41 [DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 41] is a cytosolic helicase sensor for dsDNA, DNA/RNA complexes, and cyclic dinucleotides (CDNs). Its N-terminal domain is responsible for translocation from the cytoplasm to the nucleus. Its DEAD domain, with its signature aspartate-glutamate-alanine-aspartate motif, is important for ATP-powered DNA/CDN detection and signaling. The remaining C-terminal domain functions as a
DDX41Transcreener ADP ATPase Assay
Read more
  • Published in Emerging Targets, HTS Assays, Innate Immunity
No Comments

The Role of ALPK1 in Health and Disease

Thursday, 12 May 2022 by Bellbrook Labs
Scientist Studying ALKPK1
ALPK1 (Alpha Kinase 1) is an atypical serine/threonine-protein kinase that specifically detects and binds the pathogen-associated pattern metabolites (PAMPs), ADP-beta-D-manno-heptose (Beta-ADP-Heptose) or D-glycero-beta-D-manno-heptose 1,7-bisphosphate (HBP). These metabolic precursors of lipopolysaccharide (LPS) biosynthesis are present in all Gram-negative and some Gram-positive bacteria.  This interaction stimulates ALPK1 to phosphorylate and activate TIFA, initiating an innate immune response
ALPK1Kinase Assay Kit
Read more
  • Published in Emerging Targets, HTS Assays, Innate Immunity
No Comments

Resolving the Many Roles of DHX36

Wednesday, 27 April 2022 by Bellbrook Labs
DHX36 RNA Helicase Unwinds G4 RNA Structures
While most researchers are familiar with canonical DNA structures, primarily B (but also even A or Z) DNA, an even more exotic form exerts a vast influence over nearly every aspect of nucleic acid function. In both DNA and RNA, tracts of guanine with at least four consecutive members can self-associate via Hoogsten base pairing
DHX36Helicase AssayTranscreener ADP Assay
Read more
  • Published in Emerging Targets, HTS Assays, Innate Immunity
No Comments

MAPK1, An Elusive Regulator of Innate Immunity

Wednesday, 23 February 2022 by Bellbrook Labs
Researcher working on MAPK1 pathway
Mitogen-Activated Protein Kinases (MAPKs) and MAPK Signaling Cascade Mitogen-activated protein kinases (MAPKs) are Ser/Thr kinases involved in converting extracellular signals to a large spectrum of fundamental cellular processes such as apoptosis, cell division, metabolism survival, etc. This signaling cascade is known as the MAPK pathway. MAPKs are highly conserved among eukaryotes, which mirrors its indispensable
Lead Discovery ServicesMAPK1Transcreener ADP Kinase Assay
Read more
  • Published in HTS Assays, Innate Immunity
No Comments

The Double-Edged Sword in Cancer Pathogenesis – JNK1

Wednesday, 03 November 2021 by Bellbrook Labs
JNK1 And Cancer Pathogenesis
Properties and Function of JNK1 c-Jun N-terminal kinase 1 (JNK1), also commonly known as Mitogen-Activated Protein Kinase 8 (MAPK8), is a member of the JNK subgroup of MAP kinases. JNK1 is encoded by the MAPK8 gene. MAP kinases form a superfamily of protein kinases that function by phosphorylating various protein substrates, including transcription factors, which
Innate ImmunityJNK1MAPK8Transcreener ADP Kinase Assay
Read more
  • Published in Emerging Targets, HTS Assays, Innate Immunity
No Comments

Webinar: Targeting Kinases Involved in the Innate Immune Response

Wednesday, 13 October 2021 by Bellbrook Labs
Abstract: Clinical trials continue to determine whether therapeutic modulation of kinases can be used to suppress the immune system in autoimmune diseases or stimulate for antiviral and cancer immunotherapy. The discovery and characterization of small molecule modulators have aided these efforts. The Transcreener ADP² Kinase Assay meets this need as it relies on direct ADP
Innate Immunitykinase assayTranscreener ADP Kinase Assay
Read more
  • Published in Emerging Targets, HTS Assays, Innate Immunity
No Comments
  • 1
  • 2
  • 3
  • 4
  • 5

Categories

  • Company
  • Emerging Targets
  • Epigenetics
  • HTS Assays
  • Innate Immunity
  • Neurodegenerative Diseases
  • News
  • Products
  • Resources
  • Success Stories
  • Uncategorized

Recent Posts

  • RNA Methyltransferase METTL16 Performing Many Functions

    METTL16: An RNA Methyltransferase That Wears Many Hats

    Methyltransferase-like protein 16 (METTL16) is ...
  • Researchers Identify PDE5 Inhibitor Using Transcreener Assay

    Researchers Use Transcreener Assay to Identify New PDE5 Inhibitor

    Phosphodiesterase 5 (PDE5) is most familiar in ...
  • DDX6 regulates RNA transcription and translation

    DDX6 Regulates mRNA Transcription & Translation Pathways

    DDX6 (RCK/p54) was first isolated from the RC-K...
  • Scientist using Transcreener Assay to Study PIK3CA Mutation

    Transcreener ADP2 Assay Helps Uncover the Mechanics of Oncogenic PIK3CA Mutations

    The PIK3CA gene codes for the 110 kDa catalytic...
  • DDX5 Inhibitors Targeting Colon Cancer

    Targeting DDX5 Inhibitors to Battle Cancers & Viral Infections

    DDX5 (Dead-Box 5 or p68) is a member of a famil...

Archives

BellBrook Labs
1232 Fourier Drive, Suite 115
Madison, Wisconsin 53717 USA
(608) 443-2400

info@bellbrooklabs.com

 Copyright © 2023 BellBrook Labs | All Rights Reserved | Privacy Policy | Terms of Use | FCOI | Sitemap

TOP