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Category: HTS Assays

How A PDE Activity Assay Might Help Find New Treatments for Individuals Suffering from Heart Disease

Tuesday, 06 August 2019 by Bellbrook Labs
PDE Activity Assay Heart Disease
Heart Disease: The Role of PDEs and a PDE Activity Assay Heart disease is often misunderstood due to confusion with terminology and the different types of heart disease that exist. While a heart attack can occur quickly, heart failure is a slower progression where the heart weakens over time. One thing is certain; heart disease
PDE Activity AssayPhosphodiesterase AssayTranscreener AMP/GMP Assay
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  • Published in HTS Assays
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High Throughput Screening Assays for Drug Discovery

Tuesday, 23 July 2019 by Bellbrook Labs
High Throughput Screening Assays for Drug Discovery
The world of drug discovery is exciting, yet challenging. High throughput screening assays (HTS Assays) have changed scientific research and biological testing, allowing for greater efficiency and lower costs.  This is just one case where automation has paid off. Just ask the scientists that aren’t doing repetitive pipetting, doctors getting faster testing results, or patients
High Throughput Screening AssaysHTS Assays
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ABC Transporter ATPase Assay Helps Discover MsbA Inhibitors

Tuesday, 16 July 2019 by Bellbrook Labs
ABC Transporter ATPase Assay Inhibitor
MsbA Inhibitors Help Fight Against Gram-Negative Bacteria As pathogens continue to wreak havoc on human health, new therapeutics are needed. HTS compatible assays such as the Transcreener ABC Transporter ATPase Assay help pave the way to establish new treatments. Gram-negative bacterial pathogens pose grave dangers in clinical and environmental settings alike. They include foodborne disease
ABC Transporter ATPase AssayATPase AssayTranscreener ADP ATPase AssayTranscreener ADP Kinase Assay
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  • Published in Emerging Targets, HTS Assays, Success Stories
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Using a Glycosyltransferase Activity Assay to Study Glycosylation and the Function of GTs

Tuesday, 09 July 2019 by Bellbrook Labs
Glycosyltransferase Activity Assay and Lysosomal Storage Disorders
Glycosyltransferase (GT) enzymes are incredibly diverse in their abilities to catalyze the transfer of sugar molecules to protein, carbohydrate, and lipid substrates. GTs have various metabolic and regulatory roles in biology. Glycosyltransferase targets provide different areas of therapeutic potential in a wide array of disease, including cancer, metabolic disorders, and infectious disease. A glycosyltransferase activity
Glycosyltransferase Activity AssayLysosomal Storage DisordersTranscreener UDP Assay
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  • Published in Emerging Targets, HTS Assays
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Novartis Uses Lipid Kinase Assay in a Quest for a PI4K Inhibitor

Tuesday, 25 June 2019 by Bellbrook Labs
Lipid Kinase Assay PI4K Inhibitor
Did you know that diarrhea is the second leading cause of death globally among children under the age of 5?1 Perhaps you have heard of one of the many diarrheal diseases such as cryptosporidiosis caused by a parasite called Cryptosporidium. Many people in the US might associate swimming pools with outbreaks of cryptosporidiosis due to
Lipid Kinase AssayPI4K Activity AssayTranscreener ADP Kinase Assay
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  • Published in HTS Assays, Success Stories
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One Way to Accelerate Biochemical Assay Development

Wednesday, 12 June 2019 by Bellbrook Labs
Biochemical Assay Development
In vitro biochemical assay development can be a long and expensive process, consuming months and thousands of dollars.1 Finding an off-the-shelf solution that’s been proven in drug discovery can help remove some of the painstaking labor required for enzymatic assay development. While there is a wide range of biochemical assays for high throughput screening commercially
Assay DevelopmentBiochemical Assay
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  • Published in HTS Assays
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Ubiquitin Ligase Assay: A Handy Tool for Drug Discovery

Wednesday, 29 May 2019 by Bellbrook Labs
Ubiquitin Ligase Assay Tool for Drug Discovery
Can one cellular pathway contribute to many different types of disease? Research has shown that Ubiquitination is one such pathway due to its role in the regulation of protein degradation within homeostasis, cell cycle, and DNA repair. It has been established that at least the following diseases are among those affected from alterations in this
Transcreener AMP/GMP Assayubiquitin ligase assay
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  • Published in Emerging Targets, HTS Assays
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Could an Inhibitor of Phosphodiesterase Activity be a Treatment for Alzheimer’s?

Tuesday, 14 May 2019 by Bellbrook Labs
As we continue to increase our lifespan, diseases such as Alzheimer’s will subsequently persist to develop. With up to 4.5 million Americans currently affected, there’s a strong desire to find a cure or at the very least some relief from the symptoms.¹   Neurodegeneration derived memory loss is the most common and perhaps the most devastating result
Phosphodiesterase AssayTranscreener AMP/GMP Assay
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  • Published in Emerging Targets, HTS Assays
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Immuno-Oncology Drug Discovery: A CD39 Activity Assay for a Promising Target

Thursday, 02 May 2019 by Bellbrook Labs
Cancer Cell T Cell CD39 Activity Assay
What comes to mind when you think of immunotherapy? The immune system, with all its complexities, contributes to numerous diseases that affect our society. It’s no wonder scientists scramble to find therapies that will either suppress (suppression immunotherapies) or activate (activation immunotherapies) an immune response. Immunotherapy isn’t only used for autoimmune diseases or infectious disease.
cd39 assayTranscreenerTranscreener AMP/GMP Assay
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  • Published in Emerging Targets, HTS Assays
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How a Methyltransferase Activity Assay Could Help Identify Novel Breast Cancer Treatments

Monday, 22 April 2019 by Bellbrook Labs
Pink Stethascope DOT1L Breast Cancer Target 420 X 280
As estrogen receptor (ER) positive breast cancer (BC) becomes resistant to antiestrogen therapy, novel ways to control the disease are and continue to be developed. There are different types of breast cancer, and the most effective treatment depends on knowing this difference.  For example, if the type is estrogen receptor positive (ER) meaning cells are
AptaFluor SAH Methyltransferase Assaymethyltransferase
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