How A PDE Activity Assay Might Help Find New Treatments for Individuals Suffering from Heart Disease
Tuesday, 06 August 2019
Heart Disease: The Role of PDEs and a PDE Activity Assay Heart disease is often misunderstood due to confusion with terminology and the different types of heart disease that exist. While a heart attack can occur quickly, heart failure is a slower progression where the heart weakens over time. One thing is certain; heart disease
- Published in HTS Assays
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High Throughput Screening Assays for Drug Discovery
Tuesday, 23 July 2019
The world of drug discovery is exciting, yet challenging. High throughput screening assays (HTS Assays) have changed scientific research and biological testing, allowing for greater efficiency and lower costs. This is just one case where automation has paid off. Just ask the scientists that aren’t doing repetitive pipetting, doctors getting faster testing results, or patients
- Published in HTS Assays
Using a Glycosyltransferase Activity Assay to Study Glycosylation and the Function of GTs
Tuesday, 09 July 2019
Glycosyltransferase (GT) enzymes are incredibly diverse in their abilities to catalyze the transfer of sugar molecules to protein, carbohydrate, and lipid substrates. GTs have various metabolic and regulatory roles in biology. Glycosyltransferase targets provide different areas of therapeutic potential in a wide array of disease, including cancer, metabolic disorders, and infectious disease. A glycosyltransferase activity
- Published in Emerging Targets, HTS Assays
One Way to Accelerate Biochemical Assay Development
Wednesday, 12 June 2019
In vitro biochemical assay development can be a long and expensive process, consuming months and thousands of dollars.1 Finding an off-the-shelf solution that’s been proven in drug discovery can help remove some of the painstaking labor required for enzymatic assay development. While there is a wide range of biochemical assays for high throughput screening commercially
- Published in HTS Assays
Ubiquitin Ligase Assay: A Handy Tool for Drug Discovery
Wednesday, 29 May 2019
Can one cellular pathway contribute to many different types of disease? Research has shown that Ubiquitination is one such pathway due to its role in the regulation of protein degradation within homeostasis, cell cycle, and DNA repair. It has been established that at least the following diseases are among those affected from alterations in this
- Published in Emerging Targets, HTS Assays
Could an Inhibitor of Phosphodiesterase Activity be a Treatment for Alzheimer’s?
Tuesday, 14 May 2019
As we continue to increase our lifespan, diseases such as Alzheimer’s will subsequently persist to develop. With up to 4.5 million Americans currently affected, there’s a strong desire to find a cure or at the very least some relief from the symptoms.¹ Neurodegeneration derived memory loss is the most common and perhaps the most devastating result
- Published in Emerging Targets, HTS Assays
Immuno-Oncology Drug Discovery: A CD39 Activity Assay for a Promising Target
Thursday, 02 May 2019
What comes to mind when you think of immunotherapy? The immune system, with all its complexities, contributes to numerous diseases that affect our society. It’s no wonder scientists scramble to find therapies that will either suppress (suppression immunotherapies) or activate (activation immunotherapies) an immune response. Immunotherapy isn’t only used for autoimmune diseases or infectious disease.
- Published in Emerging Targets, HTS Assays
How a Methyltransferase Activity Assay Could Help Identify Novel Breast Cancer Treatments
Monday, 22 April 2019
As estrogen receptor (ER) positive breast cancer (BC) becomes resistant to antiestrogen therapy, novel ways to control the disease are and continue to be developed. There are different types of breast cancer, and the most effective treatment depends on knowing this difference. For example, if the type is estrogen receptor positive (ER) meaning cells are
- Published in HTS Assays, Products