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Category: Innate Immunity

NSP14 – A Promising SARS-CoV-2 Therapeutic Target

Thursday, 20 January 2022 by Bellbrook Labs
NSP14 - Coronavirus Target
Non-Structural Proteins of Coronaviruses Coronaviruses have complex RNA-synthesizing machinery composed of many non-structural proteins (NSPs). While one-third of the viral genome encodes for structural proteins such as the spike, envelope, and nucleocapsid proteins, the remaining two-thirds encodes for NSPs. NSP genes are located within the 5’-region of the genome and studies have revealed that NSPs
Innate ImmunityNSP14Transcreener ADP Assay
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  • Published in Emerging Targets, Innate Immunity
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MDA5, A Nucleic Acid Sensor Critical for Immune Response

Monday, 15 November 2021 by Bellbrook Labs
MDA5 Innate Immunity
RLR Family of Proteins Melanoma differentiation-associated protein 5 (MDA5), also known as interferon-induced helicase-1 (IFH1), is one of the three members of the RIG-like receptors (RLRs) family of proteins. The RLR family of proteins share similar protein domains essential for their functions – namely the N-terminal caspase activation and recruit domains (CARDs), DExD/H box RNA
Innate ImmunityMDA5
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  • Published in Emerging Targets, Innate Immunity
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The Double-Edged Sword in Cancer Pathogenesis – JNK1

Wednesday, 03 November 2021 by Bellbrook Labs
JNK1 And Cancer Pathogenesis
Properties and Function of JNK1 c-Jun N-terminal kinase 1 (JNK1), also commonly known as Mitogen-Activated Protein Kinase 8 (MAPK8), is a member of the JNK subgroup of MAP kinases. JNK1 is encoded by the MAPK8 gene. MAP kinases form a superfamily of protein kinases that function by phosphorylating various protein substrates, including transcription factors, which
Innate ImmunityJNK1MAPK8Transcreener ADP Kinase Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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RIG-I: Important Sensor of Cytosolic RNA

Tuesday, 19 October 2021 by Bellbrook Labs
RIGI Cytosolic RNA Sensor
RIG-I-Like Receptors Retinoic acid-inducible gene 1 (RIG-I) is a cytoplasmic RNA helicase member of the RIG-I-like receptor (RLR) family of proteins. RIG-I is highly conserved within vertebrates. Structurally, RIG-I is comprised of three main functional domains – Caspase Activation and Recruitment Domain (CARD) for signal transduction, DExD/ H-box RNA helicase domain, and C-terminal domain for
Innate ImmunityRIG-ITranscreener ADP Assay
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  • Published in Emerging Targets, Innate Immunity
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Webinar: Targeting Kinases Involved in the Innate Immune Response

Wednesday, 13 October 2021 by Bellbrook Labs
Abstract: Clinical trials continue to determine whether therapeutic modulation of kinases can be used to suppress the immune system in autoimmune diseases or stimulate for antiviral and cancer immunotherapy. The discovery and characterization of small molecule modulators have aided these efforts. The Transcreener ADP² Kinase Assay meets this need as it relies on direct ADP
Innate Immunitykinase assayTranscreener ADP Kinase Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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IKK Complex, NF-kB, and Inflammation – An Intricate Relationship

Tuesday, 07 September 2021 by Bellbrook Labs
IKK Complex & Inflammation
Components of the IKK Complex The IκB kinase (IKK) complex consists of two catalytic subunits IKKα (IKK1) and IKKβ (IKK2), as well as a non-catalytic accessory protein IKKγ. IKKγ is also known as NF-κB essential modulator (NEMO). IKKα and IKKβ have high sequence homology and hence, are structurally similar. Both of those subunits possess phosphorylating
IKK Kinasekinase assayTranscreener ADP Kinase Assay
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  • Published in Emerging Targets, Innate Immunity
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The Role of CD38 Activity in the Impaired Immune Response

Tuesday, 10 August 2021 by Bellbrook Labs
Scientist Working on CD38 Discovery
Cluster of differentiation 38 (CD38) is a multifaceted protein contributing to immune response, cell adhesion, and signal transduction. Furthermore, it plays a vital role in calcium signaling, which is necessary for further cell signaling. Calcium acts as a second messenger regulating muscle contraction, cell growth, fertilization, and cellular motility, to name a few areas of
CD38 AssayTranscreener AMP/GMP Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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JAK3 Inhibitors in the Treatment of Autoimmune Disease

Tuesday, 27 July 2021 by Bellbrook Labs
JAK3 Inhibitors In the Fight Against Autoimmune Disease
Autoimmune disorders such as multiple sclerosis, psoriasis, and rheumatoid arthritis (RA), just to name a few, affect millions of people and have various contributing factors that lead to disease; some known and some unknown.   These disorders occur due to the immune system’s failure to discriminate between self vs. foreign entities. Janus Kinase 3 (JAK3) is
JAK3 InhibitorsTranscreener ADP Kinase Assay
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  • Published in Innate Immunity, Products
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Targeting Adenosine Kinase in the Fight Against Neurological Disorders

Monday, 28 June 2021 by Bellbrook Labs
Targeting Adenosine Kinase In the Fight Against Neurological Disorders
Could targeting Adenosine Kinase help lead to treatments for neurological disorders and chronic pain? Adenosine, one of four nucleoside building blocks to DNA and RNA, has a shielding effect on a wide range of conditions, including inflammation, various forms of neuronal hyperexcitability, and/or toxicity, including hypoxia, seizures, and chronic pain. This cellular activity modulator brings
Adenosine Kinase AssayTranscreener ADP Kinase Assay
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  • Published in Emerging Targets, Innate Immunity, Neurodegenerative Diseases
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NSP13 Inhibitors for the Potential Treatment of COVID-19

Monday, 14 June 2021 by Bellbrook Labs
NSP13 Inhibitors as COVID-19 Treatments
Could NSP13 be the target to help treat some respiratory infections such as SARS-CoV-2? Respiratory diseases caused by coronaviruses (CoVs) vary in symptoms, severity, and risk. Typically, symptoms are mild and known as the common cold, while others are more severe and lead to pneumonia or bronchitis, chest pains, and possibly death. SARS-CoV and MERS-CoV
Helicase AssayNSP13 InhibitorsTranscreener ADP ATPase Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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