The Role of CD38 Activity in the Impaired Immune Response
Tuesday, 10 August 2021
Cluster of differentiation 38 (CD38) is a multifaceted protein contributing to immune response, cell adhesion, and signal transduction. Furthermore, it plays a vital role in calcium signaling, which is necessary for further cell signaling. Calcium acts as a second messenger regulating muscle contraction, cell growth, fertilization, and cellular motility, to name a few areas of
- Published in Emerging Targets, HTS Assays, Innate Immunity
No Comments
JAK3 Inhibitors in the Treatment of Autoimmune Disease
Tuesday, 27 July 2021
Autoimmune disorders such as multiple sclerosis, psoriasis, and rheumatoid arthritis (RA), just to name a few, affect millions of people and have various contributing factors that lead to disease; some known and some unknown. These disorders occur due to the immune system’s failure to discriminate between self vs. foreign entities. Janus Kinase 3 (JAK3) is
- Published in Innate Immunity, Products
Targeting Adenosine Kinase in the Fight Against Neurological Disorders
Monday, 28 June 2021
Could targeting Adenosine Kinase help lead to treatments for neurological disorders and chronic pain? Adenosine, one of four nucleoside building blocks to DNA and RNA, has a shielding effect on a wide range of conditions, including inflammation, various forms of neuronal hyperexcitability, and/or toxicity, including hypoxia, seizures, and chronic pain. This cellular activity modulator brings
- Published in Emerging Targets, Innate Immunity, Neurodegenerative Diseases
NSP13 Inhibitors for the Potential Treatment of COVID-19
Monday, 14 June 2021
Could NSP13 be the target to help treat some respiratory infections such as SARS-CoV-2? Respiratory diseases caused by coronaviruses (CoVs) vary in symptoms, severity, and risk. Typically, symptoms are mild and known as the common cold, while others are more severe and lead to pneumonia or bronchitis, chest pains, and possibly death. SARS-CoV and MERS-CoV
- Published in Emerging Targets, HTS Assays, Innate Immunity
Using a PKR Inhibitor Assay in the Fight Against Viruses
Tuesday, 01 June 2021
Can a novel PKR inhibitor help lead to new treatments for viral infections? – While the human immune response is astounding and works hard to keep us alive in the face of the many germs we encounter daily, it is exceedingly complex. Unlike the adaptive immune response, the innate response acts quickly. It is considered
- Published in Emerging Targets, HTS Assays, Innate Immunity