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Category: Neurodegenerative Diseases

DDX6 Regulates mRNA Transcription & Translation Pathways

Monday, 10 July 2023 by Bellbrook Labs
DDX6 regulates RNA transcription and translation
DDX6 (RCK/p54) was first isolated from the RC-K8 B-cell lymphoma line over 30 years ago. This 472 amino acid, 53.2 kDa “DEAD-Box” ATP-dependent RNA helicase bears the signature Asp-Glu-Ala-Asp motif, characteristic of all DEAD box proteins. Dead box proteins contain both ATPase and helicase activity, and are known for their particular protein-protein and RNA-protein interactions
cancerDDX6Helicase AssayInnate Immunityneurodegenerative diseaseTranscreener ADP Assayviral infections
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  • Published in Emerging Targets, HTS Assays, Innate Immunity, Neurodegenerative Diseases
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SARM1 Forefronts Research into Major Neurological Diseases

Monday, 19 December 2022 by Bellbrook Labs
SARM1 Causes Axonal Death
SARM1 [Sterile alpha & toll/interleukin receptor (TIR) motif-containing protein 1] consists of a N-terminal mitochondrial localization sequence (NLS), an autoinhibitory HEAT/armadillo (ARM) domain, two tandem sterile alpha motif domains (SAMs), and a C-terminal toll/interleukin receptor domain (TIR). It is a human toll like receptor (TLR) adaptor protein. TLR adaptors (MYD88, MAL, TRIF, & TRAM) usually
Innate Immunityneurodegenerative diseaseneurological diseaseneuronal cell deathSARM1
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  • Published in Emerging Targets, Innate Immunity, Neurodegenerative Diseases
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SIRT2 Isoforms in Neurodegenerative Diseases & Cancer

Tuesday, 29 November 2022 by Bellbrook Labs
SIRT2 Affects Neurodegenerative Diseases
Silent information regulator type 2 (Sirtuin 2 or SIRT2) is a highly evolutionarily conserved NAD+ dependent deacetylase. SIRT2 is the only Sirtuin that acts in the cytosol. It expresses in almost all tissues, but most abundantly in the central nervous system. While SIRT2 is classified as a type III histone deacetylase, it is also capable
Innate Immunityneurodegenerative diseaseSIRT2Sirtuin 2
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  • Published in Emerging Targets, HTS Assays, Innate Immunity, Neurodegenerative Diseases
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Targeting Adenosine Kinase in the Fight Against Neurological Disorders

Monday, 28 June 2021 by Bellbrook Labs
Targeting Adenosine Kinase In the Fight Against Neurological Disorders
Could targeting Adenosine Kinase help lead to treatments for neurological disorders and chronic pain? Adenosine, one of four nucleoside building blocks to DNA and RNA, has a shielding effect on a wide range of conditions, including inflammation, various forms of neuronal hyperexcitability, and/or toxicity, including hypoxia, seizures, and chronic pain. This cellular activity modulator brings
Adenosine Kinase AssayTranscreener ADP Kinase Assay
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  • Published in Emerging Targets, Innate Immunity, Neurodegenerative Diseases
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The Curious Neuroprotective Effects of Protein Kinase A-active Agents

Tuesday, 22 December 2015 by Bellbrook Labs
The impact of neurodegenerative disorders is profound. An estimated 1 million people in the U.S. endure Parkinson’s disease1, and another 5.3 million live with Alzheimer’s disease2. Over 69,000 ischemic strokes occur each year in the U.S.3, and those lucky enough to survive them are at risk for neurodegeneration. There is tremendous need for a better
apoptosisneuronal cell deathneuroprotectionPKAprotein kinase aTranscreener ADP Kinase Assay
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  • Published in Neurodegenerative Diseases
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Targeting Phosphodiesterase 4B for Cognitive Disorders

Thursday, 27 August 2015 by Robert Lowery
Cognitive dysfunction, including loss of core functions such as memory, learning and reasoning occurs in many psychiatric disorders, and impairs the quality of life for millions of older adults suffering from dementia. As there is no single cause, treatments vary. However the few drugs that are available, most of which boost neurotransmitter levels, are not
Transcreener AMP/GMP Assay
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  • Published in Neurodegenerative Diseases
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RGS4 Inhibitor Shows Activity in Parkinson’s Disease Model

Thursday, 18 June 2015 by Robert Lowery
RGS (regulator of G-protein signaling) proteins attenuate GPCR signals and provide an intriguing alternative to direct receptor targeting for modulating GPCR pathways. A recent effort led by Richard Neubig at Michigan State University (Blazer, et al ACS Chem Neurosci. 2015 Apr 20) provides a big boost to validation of RGS proteins as drug targets. Their
Assay Development Services
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  • Published in Neurodegenerative Diseases
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Brain Penetrant LRRK2 GTPase Inhibitor Shows Promise For PD

Thursday, 24 July 2014 by katie.lowery
Parkinson’s disease (PD), a progressive neurodegenerative disorder caused by the loss of dopaminergic neurons, currently affects nearly 7 million people worldwide.  Mutations in leucine-rich repeat kinase 2 (LRRK2), a dual functional protein with separate kinase and GTPase domains, are the most common cause of autosomal dominant PD and also contribute to sporadic PD. Multiple lines
Transcreener ADP Kinase AssayTranscreener GDP Assay
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  • Published in Neurodegenerative Diseases
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Pharmacoperones: Correcting Misfolded Proteins, Curing Disease.

Thursday, 09 January 2014 by katie.lowery
Researchers from Oregon Health and Science University (OHSU), led by P. Michael Conn, have demonstrated in mice a novel technique used to cure disease caused by misfolded protein molecules.  The same technique could be used to cure human diseases with similar etiology.    Human diseases caused by misfolded proteins are diverse and numerous.  Among them
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  • Published in Neurodegenerative Diseases
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The Smell Test: Peanut Butter and Alzheimer’s

Wednesday, 06 November 2013 by katie.lowery
New research suggests peanut butter as innovative diagnostic tool.  Imagine: you wake up one day to find you can no longer enjoy the scent of peanut butter.  Now imagine this: you wake up two years later to find you can no longer remember your spouse’s name.  Could the first unfortunate scenario be a pre-cursor to
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  • Published in Neurodegenerative Diseases
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Recent Posts

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  • Researchers Identify PDE5 Inhibitor Using Transcreener Assay

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  • DDX6 regulates RNA transcription and translation

    DDX6 Regulates mRNA Transcription & Translation Pathways

    DDX6 (RCK/p54) was first isolated from the RC-K...
  • Scientist using Transcreener Assay to Study PIK3CA Mutation

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    The PIK3CA gene codes for the 110 kDa catalytic...

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