• Assay Selection Tool

BellBrook Labs

  • Products
    • Transcreener® HTS Assay Kits
      • Transcreener® ADP² Kinase Assay Kits
        • Transcreener® ADP2 Assay Kit – FP Readout
        • Transcreener® ADP2 Assay Kit – FI Readout
        • Transcreener® ADP2 Assay Kit – TR-FRET Readout
      • Transcreener® ADO CD73 Assay Kit
      • Transcreener® AMP²/GMP² Phosphodiesterase Assay Kits
        • Transcreener® AMP2/GMP2 FP Assay
        • Transcreener® AMP2/GMP2 Assay Kit – TR-FRET Readout
      • Transcreener® cGAMP cGAS Assay Kits
        • Transcreener® cGAMP Assay Kit – FP Readout
        • Transcreener® cGAMP Assay Kit – TR-FRET Readout
      • Transcreener dAMP Exonuclease Assay Kit
      • Transcreener® EPIGEN SAH Methyltransferase Assay Kit
      • Transcreener® GDP GTPase Assay Kits
        • Transcreener® GDP Assay Kit – FP Readout
        • Transcreener® GDP Assay Kit – FI Readout
        • Transcreener® GDP Assay Kit – TR-FRET Readout
      • Transcreener® UDP² Glycosyltransferase Assay Kits
        • Transcreener® UDP2 Assay Kit – FP Readout
        • Transcreener® UDP2 Assay Kit – FI Readout
        • Transcreener® UDP2 Assay Kit – TR-FRET Readout
      • Transcreener® 2-5A OAS Assay Kit
    • AptaFluor® HTS Assay Kits
      • AptaFluor® SAH Methyltransferase Assay Kit
    • Enzyme Assay Systems
      • TREX1 Assay System
    • Recombinant Enzymes
      • Human cGAS Enzyme
      • Mouse cGAS Enzyme
      • Human DDX3 Enzyme
      • Human OAS1 Enzyme
      • Human TREX1 Enzyme
    • Assay Plates
    • Ordering Information
  • Services
    • Assay Development Services
    • Lead Discovery Services
    • CD38 Assay Services
    • GTPase Profiling Services
  • Assays by Target
    • Kinase Assays
      • ADK Assays – Application
      • AMPK Assays – Application
      • IKK-beta Assays – Application
      • IRAK4 Assays – Application
      • JAK1 Assays – Application
      • JAK3 Assays – Application
      • MAPK8 Assays – Application
      • PKR Assays – Application
      • RIPK1 Assays – Application
      • TBK1 Assays – Application
    • GTPase Assays
      • GAP Assays – Application
      • GEF Assays – Application
      • KRAS Assays – Application
      • HRAS Assays – Application
      • NRAS Assays – Application
      • RRAS Assays – Application
      • Rac1 Assays – Application
      • RhoA Assays – Application
      • RhoC Assays – Application
      • Cdc42 Assays – Application
      • Ran Assays – Application
    • Methyltransferase Assays
      • EZH2 Assays – Application
      • G9a Assays – Application
      • SET7/9 Assays – Application
      • SET8 Assays – Application
      • PRMT1 Assays – Application
      • PRMT3 Assays – Application
      • PRMT4 Assays – Application
    • STING Pathway Assays
      • cGAS Assay Kits
      • ENPP1 Assays – Application
      • TREX1 Assay System
      • IKK-beta Assays – Application
      • TBK1 Assays – Application
    • Nucleotidase Assays
      • CD38 Assay Services
      • CD39 Assays – Application
      • CD73 Activity Assay Kits
    • Helicase / ATPase Assays
      • DDX3 Assays – Application
      • NSP13 Assays – Application
      • P97 Assays – Application
    • Glycosyltransferase Assays
      • Toxin B Assays – Application
      • GALNT2 Assays – Application
      • GALNT3 Assays – Application
      • BGalT1 Assays – Application
    • Phosphodiesterase Assays
      • PDE3 Assays – Application
      • PDE4 Assays – Application
      • PDE5 Assays – Application
      • PDE7 Assays – Application
    • Ligase and Synthetase Assays
      • SUMO E1 Assays – Application
      • Acyl CoA Synthetase Assays – Application
      • S-Acetyl CoA Synthetase Assays – Application
    • Exonuclease Assays
      • TREX1 Assay System
    • OAS Assays
      • OAS1 Assay Kits
    • Other Enzyme Assays
      • NUDT5 Assays – Application
  • Resources
    • Technical Manuals
    • Transcreener® Assays – Instrument Compatibility
    • Application Notes
    • Posters and Presentations
    • Publications
    • Transcreener® FAQ’s
    • Guides
      • Residence Time Guide
      • Hit Prioritization Guide
      • Kinases in Innate Immunity
  • Company
    • President’s Message
    • International Distributors
    • Careers
    • Downloads
    • Contact Us
  • Blog
  • MY CART
    No products in cart.

Category: Neurodegenerative Diseases

SARM1 Forefronts Research into Major Neurological Diseases

Monday, 19 December 2022 by Bellbrook Labs
SARM1 Causes Axonal Death
SARM1 [Sterile alpha & toll/interleukin receptor (TIR) motif-containing protein 1] consists of a N-terminal mitochondrial localization sequence (NLS), an autoinhibitory HEAT/armadillo (ARM) domain, two tandem sterile alpha motif domains (SAMs), and a C-terminal toll/interleukin receptor domain (TIR). It is a human toll like receptor (TLR) adaptor protein. TLR adaptors (MYD88, MAL, TRIF, & TRAM) usually
Innate Immunityneurodegenerative diseaseneurological diseaseneuronal cell deathSARM1
Read more
  • Published in Emerging Targets, Innate Immunity, Neurodegenerative Diseases
No Comments

SIRT2 Isoforms in Neurodegenerative Diseases & Cancer

Tuesday, 29 November 2022 by Bellbrook Labs
SIRT2 Affects Neurodegenerative Diseases
Silent information regulator type 2 (Sirtuin 2 or SIRT2) is a highly evolutionarily conserved NAD+ dependent deacetylase. SIRT2 is the only Sirtuin that acts in the cytosol. It expresses in almost all tissues, but most abundantly in the central nervous system. While SIRT2 is classified as a type III histone deacetylase, it is also capable
Innate Immunityneurodegenerative diseaseSIRT2Sirtuin 2
Read more
  • Published in Emerging Targets, HTS Assays, Innate Immunity, Neurodegenerative Diseases
No Comments

Targeting Adenosine Kinase in the Fight Against Neurological Disorders

Monday, 28 June 2021 by Bellbrook Labs
Targeting Adenosine Kinase In the Fight Against Neurological Disorders
Could targeting Adenosine Kinase help lead to treatments for neurological disorders and chronic pain? Adenosine, one of four nucleoside building blocks to DNA and RNA, has a shielding effect on a wide range of conditions, including inflammation, various forms of neuronal hyperexcitability, and/or toxicity, including hypoxia, seizures, and chronic pain. This cellular activity modulator brings
Adenosine Kinase AssayTranscreener ADP Kinase Assay
Read more
  • Published in Emerging Targets, Innate Immunity, Neurodegenerative Diseases
No Comments

The Curious Neuroprotective Effects of Protein Kinase A-active Agents

Tuesday, 22 December 2015 by Bellbrook Labs
The impact of neurodegenerative disorders is profound. An estimated 1 million people in the U.S. endure Parkinson’s disease1, and another 5.3 million live with Alzheimer’s disease2. Over 69,000 ischemic strokes occur each year in the U.S.3, and those lucky enough to survive them are at risk for neurodegeneration. There is tremendous need for a better
apoptosisneuronal cell deathneuroprotectionPKAprotein kinase aTranscreener ADP Kinase Assay
Read more
  • Published in Neurodegenerative Diseases
No Comments

Targeting Phosphodiesterase 4B for Cognitive Disorders

Thursday, 27 August 2015 by Robert Lowery
Cognitive dysfunction, including loss of core functions such as memory, learning and reasoning occurs in many psychiatric disorders, and impairs the quality of life for millions of older adults suffering from dementia. As there is no single cause, treatments vary. However the few drugs that are available, most of which boost neurotransmitter levels, are not
Transcreener AMP/GMP Assay
Read more
  • Published in Neurodegenerative Diseases
No Comments

RGS4 Inhibitor Shows Activity in Parkinson’s Disease Model

Thursday, 18 June 2015 by Robert Lowery
RGS (regulator of G-protein signaling) proteins attenuate GPCR signals and provide an intriguing alternative to direct receptor targeting for modulating GPCR pathways. A recent effort led by Richard Neubig at Michigan State University (Blazer, et al ACS Chem Neurosci. 2015 Apr 20) provides a big boost to validation of RGS proteins as drug targets. Their
Assay Development Services
Read more
  • Published in Neurodegenerative Diseases
No Comments

Brain Penetrant LRRK2 GTPase Inhibitor Shows Promise For PD

Thursday, 24 July 2014 by katie.lowery
Parkinson’s disease (PD), a progressive neurodegenerative disorder caused by the loss of dopaminergic neurons, currently affects nearly 7 million people worldwide.  Mutations in leucine-rich repeat kinase 2 (LRRK2), a dual functional protein with separate kinase and GTPase domains, are the most common cause of autosomal dominant PD and also contribute to sporadic PD. Multiple lines
Transcreener ADP Kinase AssayTranscreener GDP Assay
Read more
  • Published in Neurodegenerative Diseases
No Comments

Pharmacoperones: Correcting Misfolded Proteins, Curing Disease.

Thursday, 09 January 2014 by katie.lowery
Researchers from Oregon Health and Science University (OHSU), led by P. Michael Conn, have demonstrated in mice a novel technique used to cure disease caused by misfolded protein molecules.  The same technique could be used to cure human diseases with similar etiology.    Human diseases caused by misfolded proteins are diverse and numerous.  Among them
Read more
  • Published in Neurodegenerative Diseases
No Comments

The Smell Test: Peanut Butter and Alzheimer’s

Wednesday, 06 November 2013 by katie.lowery
New research suggests peanut butter as innovative diagnostic tool.  Imagine: you wake up one day to find you can no longer enjoy the scent of peanut butter.  Now imagine this: you wake up two years later to find you can no longer remember your spouse’s name.  Could the first unfortunate scenario be a pre-cursor to
Read more
  • Published in Neurodegenerative Diseases
No Comments

Categories

  • Company
  • Emerging Targets
  • Epigenetics
  • HTS Assays
  • Innate Immunity
  • Neurodegenerative Diseases
  • News
  • Products
  • Resources
  • Success Stories
  • Uncategorized

Recent Posts

  • SLAS 2023 Conference Exhibitor Announcement

    SLAS 2023 – HTS Assays and Discovery Services

    BellBrook Labs will exhibit and present posters...
  • BTK's Involved in Systemic lupus erythematosus

    The Challenging Search for BTK Inhibitors

    Bruton’s Tyrosine Kinase (BTK) is a 76kDa...
  • SARM1 Causes Axonal Death

    SARM1 Forefronts Research into Major Neurological Diseases

    SARM1 [Sterile alpha & toll/interleukin rec...
  • SIRT2 Affects Neurodegenerative Diseases

    SIRT2 Isoforms in Neurodegenerative Diseases & Cancer

    Silent information regulator type 2 (Sirtuin 2 ...
  • Patient With WRN Helicase Syndrome

    Can WRN Helicase Inhibitors Treat MSI-H Cancers?

    Over 100 years ago, Otto Werner first character...

Archives

BellBrook Labs
5500 Nobel Drive, Suite 230
Madison, Wisconsin 53711 USA
(608) 443-2400

info@bellbrooklabs.com

 Copyright © 2022 BellBrook Labs | All Rights Reserved | Privacy Policy | Terms of Use | FCOI | Sitemap

TOP