• Assay Selection Tool

BellBrook Labs

  • Products
    • Transcreener® HTS Assays
      • Transcreener® ADP² Kinase Assay
      • Transcreener® ADO CD73 Assay
      • Transcreener® AMP²/GMP² Phosphodiesterase Assay
      • Transcreener® cGAMP cGAS Assay
      • Transcreener® GDP GTPase Assay Kits
      • Transcreener® UDP² Glycosyltransferase Assay
      • Transcreener® EPIGEN SAH Methyltransferase Assay
    • AptaFluor® HTS Assays
      • AptaFluor® SAH Methyltransferase Assay
    • HTS Assays by Target Family
      • Kinase Assay Kits
      • ATPase Assay Kits
      • Glycosyltransferase Assay Kits
      • GTPase Assay Kits
        • GAP Assay Kits
        • GEF Assay Kits
      • Methyltransferase Assay Kits
      • Ligase and Synthetase Assay Kits
      • Phosphodiesterase Assay Kits
    • HTS Assays by Target
      • AMPK Assay Kits
      • cGAS Assay Kits
      • CD39 Assay Kits
      • CD73 Assay Kits
      • ENPP1 Assay Kits
      • EZH2 Assay Kits
      • IKK-beta Assay Kits
      • IRAK4 Assay Kits
      • JAK1 Assay Kits
      • JAK3 Assay Kits
      • TBK1 Assay Kits
    • Recombinant cGAS Enzyme
      • Human cGAS Enzyme
      • Mouse cGAS Enzyme
    • Assay Plates
    • Ordering Information
  • Services
    • Assay Development Services
    • Lead Discovery Services
    • GTPase Profiling Services
  • Innate Immunity
    • cGAS Activity Assays
    • CD73 Activity Assays
    • CD39 Activity Assays
    • ENPP1 Activity Assays
    • IKK-beta Activity Assays
    • IRAK4 Activity Assays
    • JAK1 Activity Assays
    • JAK3 Activity Assays
    • TBK1 Activity Assays
  • Resources
    • Application Notes
    • Transcreener® Assays – Instrument Compatibility
    • Posters and Presentations
    • Publications
    • Technical Manuals
    • Transcreener® FAQ’s
    • Guides
      • Residence Time Guide
      • Hit Prioritization Guide
  • Company
    • President’s Message
    • International Distributors
    • Careers
    • Downloads
    • Contact Us
  • Blog
  • MY CART
    No products in cart.

Category: Neurodegenerative Diseases

The Curious Neuroprotective Effects of Protein Kinase A-active Agents

Tuesday, 22 December 2015 by Bellbrook Labs
The impact of neurodegenerative disorders is profound. An estimated 1 million people in the U.S. endure Parkinson’s disease1, and another 5.3 million live with Alzheimer’s disease2. Over 69,000 ischemic strokes occur each year in the U.S.3, and those lucky enough to survive them are at risk for neurodegeneration. There is tremendous need for a better
apoptosisneuronal cell deathneuroprotectionPKAprotein kinase aTranscreener ADP Kinase Assay
Read more
  • Published in Neurodegenerative Diseases
No Comments

Targeting Phosphodiesterase 4B for Cognitive Disorders

Thursday, 27 August 2015 by Robert Lowery
Cognitive dysfunction, including loss of core functions such as memory, learning and reasoning occurs in many psychiatric disorders, and impairs the quality of life for millions of older adults suffering from dementia. As there is no single cause, treatments vary. However the few drugs that are available, most of which boost neurotransmitter levels, are not
Transcreener AMP/GMP Assay
Read more
  • Published in Neurodegenerative Diseases
No Comments

RGS4 Inhibitor Shows Activity in Parkinson’s Disease Model

Thursday, 18 June 2015 by Robert Lowery
RGS (regulator of G-protein signaling) proteins attenuate GPCR signals and provide an intriguing alternative to direct receptor targeting for modulating GPCR pathways. A recent effort led by Richard Neubig at Michigan State University (Blazer, et al ACS Chem Neurosci. 2015 Apr 20) provides a big boost to validation of RGS proteins as drug targets. Their
Assay Development Services
Read more
  • Published in Neurodegenerative Diseases
No Comments

Brain Penetrant LRRK2 GTPase Inhibitor Shows Promise For PD

Thursday, 24 July 2014 by katie.lowery
Parkinson’s disease (PD), a progressive neurodegenerative disorder caused by the loss of dopaminergic neurons, currently affects nearly 7 million people worldwide.  Mutations in leucine-rich repeat kinase 2 (LRRK2), a dual functional protein with separate kinase and GTPase domains, are the most common cause of autosomal dominant PD and also contribute to sporadic PD. Multiple lines
Transcreener ADP Kinase AssayTranscreener GDP Assay
Read more
  • Published in Neurodegenerative Diseases
No Comments

Pharmacoperones: Correcting Misfolded Proteins, Curing Disease.

Thursday, 09 January 2014 by katie.lowery
Researchers from Oregon Health and Science University (OHSU), led by P. Michael Conn, have demonstrated in mice a novel technique used to cure disease caused by misfolded protein molecules.  The same technique could be used to cure human diseases with similar etiology.    Human diseases caused by misfolded proteins are diverse and numerous.  Among them
Read more
  • Published in Neurodegenerative Diseases
No Comments

The Smell Test: Peanut Butter and Alzheimer’s

Wednesday, 06 November 2013 by katie.lowery
New research suggests peanut butter as innovative diagnostic tool.  Imagine: you wake up one day to find you can no longer enjoy the scent of peanut butter.  Now imagine this: you wake up two years later to find you can no longer remember your spouse’s name.  Could the first unfortunate scenario be a pre-cursor to
Read more
  • Published in Neurodegenerative Diseases
No Comments

Categories

  • Company
  • Emerging Targets
  • Epigenetics
  • HTS Assays
  • Neurodegenerative Diseases
  • News
  • Products
  • Resources
  • Success Stories
  • Uncategorized

Recent Posts

  • Small GTPase Modulation

    Small GTPase Modulation: GDP Assays to Accelerate Discovery

    Cancer is complex, which makes determining the ...
  • TREX1 Press Release Graphic

    BellBrook Labs Receives NIH Funding for Novel Approach to Stimulating Antitumor Immunity

    The National Cancer Institute (NCI) recently aw...
  • Researcher Using An ADP Assay

    Accelerating Discovery of Kinase Inhibitors Using an ADP Assay

    An ADP assay can be used to study the activity ...
  • Inhibitors of ENPP1 SLAS Discovery

    New Publication by the Scientists at BellBrook Labs – Development of a High-Throughput Assay to Identify Inhibitors of ENPP1

    BellBrook scientist Meera Kumar and Robert Lowe...
  • GMP Assay for PDE Inhibitor Discovery

    Using a Universal GMP Assay for PDE Research

    A universal GMP assay to aid in PDE research an...

Archives

BellBrook Labs
5500 Nobel Drive, Suite 230
Madison, Wisconsin 53711 USA
(608) 443-2400

info@bellbrooklabs.com

 Copyright © 2019 BellBrook Labs | All Rights Reserved | Privacy Policy | Terms of Use | FCOI | Sitemap

TOP