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Category: Products

OAS1: The Cost of Host Defense

Monday, 13 June 2022 by Bellbrook Labs
OAS1 The Cost of Host Defense
OAS1 (Oligoadenylate synthetase 1) is induced by type 1 interferon signaling. It recognizes 18 bp (or longer) double stranded RNA segments from invading viruses in the cytosol and catalyzes the production of 2’-5’ linked oligoadenylate (2-5A) from ATP. The 2-5A then, at the expense of yet more ATP, exclusively activates endoribonclease L (RNase L) by
Innate ImmunityOAS1Transcreener OAS Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity, Products
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Exploring the Use of NUDT5 Inhibitors to Treat Breast Cancer

Monday, 23 August 2021 by Bellbrook Labs
malignant adenocarcinoma could be treated by NUDT5 Inhibitors
NUDT5 is found to be overexpressed in certain cancers in humans Could NUDT5 inhibitors lead to new cancer treatments? NUDIX hydrolases are a superfamily of enzymes are found in all classes of organisms and are responsible for hydrolyzing modified nucleoside diphosphates. One of the most well-studied NUDIX hydrolases is NUDT1 (also known as MTH1); it
NUDIX 5 AssayNUDT5 AssayTranscreener AMP/GMP Assay
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JAK3 Inhibitors in the Treatment of Autoimmune Disease

Tuesday, 27 July 2021 by Bellbrook Labs
JAK3 Inhibitors In the Fight Against Autoimmune Disease
Autoimmune disorders such as multiple sclerosis, psoriasis, and rheumatoid arthritis (RA), just to name a few, affect millions of people and have various contributing factors that lead to disease; some known and some unknown.   These disorders occur due to the immune system’s failure to discriminate between self vs. foreign entities. Janus Kinase 3 (JAK3) is
JAK3 InhibitorsTranscreener ADP Kinase Assay
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  • Published in Innate Immunity, Products
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A Kinase Assay Kit to Interrogate Innate Immunity Targets

Thursday, 15 April 2021 by Bellbrook Labs
Performing a Kinase Assay Kit in a Lab
Kinases are essential players in cellular functions such as cell signaling, cellular transport, and protein regulation. For these reasons, many kinases are innate immunity targets. A kinase assay kit is ideal whether used for drug screening and dose-response measurements or detection when studying a particular cellular pathway. A universal ADP assay allows researchers to screen
Kinase Assay KitTranscreener ADP Kinase Assay
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Small GTPase Modulation: GDP Assays to Accelerate Discovery

Wednesday, 24 March 2021 by Bellbrook Labs
Small GTPase Modulation
Cancer is complex, which makes determining the culprit as well as individual treatment extremely challenging. A variety of cancer types exist with a multitude of contributors. As the second leading cause of death in the US, cancer has been a target scientists have been battling for decades. When DNA is damaged or mutations occur, cells
Small GTPaseTranscreener GDP Assay
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New TR-FRET Readout Now Available with the Transcreener cGAMP cGAS Assay

Thursday, 10 December 2020 by Bellbrook Labs
New cGAS TR-FRET Assay
Launched in November 2019, the Transcreener cGAMP cGAS Assay has generated a great deal of interest in the drug discovery community. While fluorescence polarization (FP) readouts offer a stable and robust option, some researchers prefer time-resolved Förster-resonance-energy-transfer (TR-FRET) readouts for large screens. After months of development, BellBrook Labs is pleased to announce the addition of
cgas assaycGAS InhibitorsTranscreener cGAMP cGAS Assay
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New Transcreener UDP2 Assay with a Fluorescence Intensity Readout

Friday, 29 May 2020 by Bellbrook Labs
Transcreener Glycosyltransferase Assay Blog
BellBrook Labs scientists have developed a new universal UDP detection assay for the measurement of Glycosyltransferase activity.  The Transcreener UDP2 FI Assay extends the Transcreener platform for UDP detection by utilizing a simple fluorescence intensity (FI) output. It can be used on fluorescence readers typically found in academic and therapeutic research laboratories, as well as
Glycosyltransferase Activity AssayTranscreener UDP Assay
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New Transcreener CD73 Assay for Discovery of Therapeutics to Enhance Tumor Immunity

Monday, 27 April 2020 by Bellbrook Labs
cGAS Inhibitors Grant
The new Transcreener CD73 Assay measures adenosine production by CD73 in a mix-and-read format with a far-red fluorescence polarization readout. The assay will accelerate efforts to discover selective CD73 antagonists for cancer immunotherapy by enabling high throughput screening, structure-driven hit-to-lead, and mechanistic studies with the purified enzyme. Madison, WI – April 27th, 2020 – Researchers
Transcreener CD73 Assay
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Recorded Webinar – Transcreener® CD73 Assay: Leveraging Nucleotide Detection to Measure Adenosine

Monday, 13 April 2020 by Bellbrook Labs
Webinar Graphic
CD73 is a plasma membrane-bound ectonucleotidase that hydrolyzes AMP into adenosine, contributing to immunosuppression in the tumor microenvironment; it is being pursued as a promising immuno-oncology drug target. In this webinar we will present the steps involved in development of the Transcreener CD73 assay. Transcreener is a biochemical HTS assay platform based on homogenous immunodetection
Transcreener CD73 Assay
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FUT7, Inflammation, and Fucosyltransferase Assays

Wednesday, 01 April 2020 by Bellbrook Labs
FUT7 Fucosyltransferase Assays and Chronic Inflammation
Inflammation is a necessary step involved in the immune response, allowing our bodies to fight and eliminate disease, allergies, and injuries. The inflammatory response recruits several mediators to aid in the destruction of whatever pathogen caused the response in the first place. Cells such as leucocytes, eosinophils, and neutrophils get recruited to the site in
Fucosyltransferase AssaysFUT7Transcreener GDP Assay
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