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Category: Uncategorized

Using a Universal GMP Assay for PDE Research

Thursday, 28 January 2021 by Bellbrook Labs
GMP Assay for PDE Inhibitor Discovery
A universal GMP assay to aid in PDE research and potential COVID-19 disruption. – Phosphodiesterase enzymes (PDEs) modulate pathways throughout the body. Since unregulated PDEs contribute to disease in many cases, it makes sense therapies that inhibit these enzymes have the potential to treat several different ailments. These include cardiovascular and respiratory issues, diabetes, fibrotic
gmp assayPDE InhibitorsPhosphodiesterase AssayTranscreener AMP/GMP Assay
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  • Published in HTS Assays, Uncategorized
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Fluorescence Polarization Assays for Drug Discovery

Friday, 06 March 2020 by Bellbrook Labs
FP Assays
Fluorescence polarization assays (FP assays) are used in a variety of ways.  From uncovering molecules in solution, to monitoring drug levels in clinical settings, and are enabling in drug discovery. These binding assays have been used to gain knowledge of molecular interactions, enzymatic activity, and nucleic acid hybridization. Moreover, scientists use FP to study small
Fluorescence PolarizationFP Assays
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  • Published in HTS Assays, Uncategorized
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TR-FRET Assays In Drug Discovery

Thursday, 06 February 2020 by Bellbrook Labs
TR-FRET Assays
Förster resonance energy transfer (FRET) technology and TR-FRET assays are used in laboratories globally for a variety of applications ranging from disease detection, to drug discovery, to monitoring genetic differences between individuals and populations. The brilliance of this technology is due to the sensitivity provided by the spectral overlap and the proximity of the acceptor
TR-FRET AssaysTranscreener ADP Kinase Assay
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Posters Presented at SLAS 2018

Wednesday, 14 February 2018 by Bellbrook Labs
Thanks to all who stopped by the booth at SLAS 2018! We appreciate the great conversation and look forward to continued discussion. Its great to hear the success stories of current Transcreener users, and to meet a new group of individuals who are searching for an HTS assay for their challenging target. For those of
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A Novel Approach Discovers Hundreds of Cancer-Relevant Arginine Methylation Sites for CARM1

Thursday, 14 December 2017 by Bellbrook Labs
Protein arginine methylation is an important post-translational modification, but its impact remains rather mysterious. Approximately 7% of all arginine residues in the human proteome are modified by mono- or di-methylation (which is a similar order of magnitude to the 9% of serine residues that are phosphorylated and the 7% of lysine residues that are ubiquitinated).¹
AptaFluor SAH Methyltransferase AssayAssay Development Servicesdrug discovery servicesEPIGEN Methyltransferase Assaymethyltransferase
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  • Published in Epigenetics, HTS Assays, Products, Uncategorized
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Doubling the Odds: Two-Pronged Strategy to Halt Cancer Cell Proliferation

Wednesday, 29 November 2017 by Bellbrook Labs
It would be difficult to underestimate the importance of polo-like kinase 1 (Plk1) for cancer, given its influence on cell division. As one of five members of the Polo-like family of serine/threonine protein kinases in eukaryotic cells, Plk1 plays a multifaceted role in the cell cycle and thus controls cancer progression fueled by unchecked cell
Assay Development Servicesdrug discovery serviceskinase assayTranscreener ADP Kinase Assay
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  • Published in HTS Assays, News, Uncategorized
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Taking Up Residence: Using the Transcreener ADP Assay to Measure the Kinetics of Kinase Inhibitor Interactions

Wednesday, 30 August 2017 by Bellbrook Labs
Classically speaking, assays for interactions between drug molecules and their targets have measured binding affinity under equilibrium conditions. In drug discovery projects, it had long been assumed that carefully measuring IC50 (half-maximal inhibitory concentration), EC50 (effector concentration for half-maximal response), Kd  (equilibrium dissociation constant), and/or Ki (inhibition constant) would allow drug candidates to be prioritized
Assay Development Servicesdrug discovery serviceskinase assayLead Discovery ServicesResidence TimeTranscreener ADP Kinase Assay
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BellBrook Labs Launches Ultra-Sensitive Methyltransferase Assay to Accelerate Epigenetic Drug Discovery

Thursday, 10 August 2017 by Bellbrook Labs
Methyltransferases have become a major focus of drug discovery for cancer and other diseases driven by epigenetic factors.  BellBrook Labs’ new, ultra-sensitive AptaFluor™ SAH Methyltransferase Assay eliminates cost and sensitivity barriers that are slowing the discovery of methyltransferase inhibitors. New AptaFluor SAH Methyltransferase Assay Schematic BellBrook Labs announces the launch of their latest drug discovery
AptaFluor SAH Methyltransferase AssayAssay Development ServicesepigeneticsLead Discovery Servicesmethyltransferase
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  • Published in Epigenetics, News, Uncategorized
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On Demand Webinar: Development of Ectonucleotidase Assay Methods Using the Transcreener® HTS Assay Platform

Wednesday, 10 May 2017 by Bellbrook Labs
View the Webinar On Demand at Anytime Ectonucleotidases are plasma membrane-bound enzymes with externally oriented active sites that metabolize nucleotides to nucleosides. One example is ectonucleoside triphosphate diphosphohydrolase-1, also known as CD39, ENTPD1, or NTPDase1. CD39 hydrolyzes ATP and ADP to AMP. Other ectonucleotidases such as CD73 process the AMP further into adenosine, which is
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Ectonucleotidases: An Outside Chance for Drug Development

Friday, 28 April 2017 by Bellbrook Labs
Sometimes, the most intriguing cellular processes happen outside of the cell. Case in point: purinergic signaling pathways, in which extracellular receptors sense levels of purines in the extracellular milieu. The result? A wide array of effects on neuronal signaling, vascular tone, thrombosis, and immune function. But what controls the level of extracellular purines? Enter ectonucleotidases:
Assay Development Servicesdrug discovery servicesLead Discovery ServicesTranscreener ADP Kinase AssayTranscreener AMP/GMP Assay
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  • Published in Emerging Targets, HTS Assays, Uncategorized
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