Discovery on Target 2017

Here is what you may have missed…


Exhibition


Presentations/Talks

Targeting the cGAS-STING Pathway Using a Homogenous, HTS Compatible Transcreener® cGAS Assay

Thursday, September 28th – 12:20 PM

Aberrant activation of the DNA sensor cyclic GAMP synthase (cGAS) by self-DNA drives serious autoimmune diseases such as systemic lupus erythematosus. To accelerate discovery of cGAS inhibitors, we developed Transcreener-based assays for detecting cGAMP, which allow sensitive measurement of cGAS enzymatic activity with FP and TR-FRET signals.


Poster Presentations

A Homogenous, High Throughput Assay to Measure Guanine Nucleotide Exchange Factor Activity Using the Transcreener® GDP Assay

Targeting CD39: A High Throughput Ectonucleotidase Assay Based on the Transcreener® AMP/GMP Assay

AptaFluor™ SAH: A Homogenous, Universal Methyltransferase Assay Based on a Microbial Riboswitch

Targeting the cGAS-STING Pathway Using a Homogenous, HTS Compatible Transcreener® cGAS Assay

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