Corning® 384-well half area plates are a great fit for Transcreener TR-FRET assays. They feature low working volume to conserve precious enzyme. BellBrook Labs recommends a final volume of 20 µL for these plates. Square well tops enable easier robotic handling, while round bottoms minimize trapped air and provide better assay Z’. Polystyrene non-binding surfaces (NBS) is Corning’s proprietary treatment which limits protein binding at low concentrations. The microplate is non-sterile and comes without a lid. However, for long incubation periods, BellBrook Labs recommends covering your sample wells to reduce evaporation.