AMPK is targeted for many diseases, including metabolism, inflammatory diseases, tumor suppression, and coronavirus. SARS-CoV-2 uses the ACE2 receptor to infect the human body. Research shows AMPK increases ACE2's expression and stability. Once coronavirus enters the body, it downregulates ACE2, causing a chain of events leading to deadly cardio-pulmonary issues.
One drug currently on the market (Metformin) activates AMPK via phosphorylation. Currently used as a diabetes drug, Metformin has positive effects on both lipid and glucose metabolism via AMPK.
Another AMPK activator AICAR has shown to improve alveolar and capillary barriers preventing damage from an infection like SARS-CoV-2 in mice. Further work needs to be done but AMPK is a target of interest for coronavirus treatment.
The Transcreener ADP2 AMPK Assay is an excellent tool for researchers examining the therapeutic effects of AMPK.