GTPases are important proteins that regulate various cell functions like signal transduction, protein biosynthesis, cell adhesion, membrane remodeling and trafficking, cytoskeletal reorganization, apoptosis, autophagy, and cell motility. They are called "master regulators" of intracellular membrane traffic because they have such extensive function in cellular operation. (Stenmark 2009)
GTPase inhibitors are attractive drug discovery targets. GTPase inhibitors are explored to treat many diseases, such as cancer and neurodegenerative diseases. To better control overactivity, we need selective technologies that assess the ability to interact with the target.
Researchers can use the Transcreener GDP GTPase Assay to study GTPases for therapeutic treatments.