GTPases are highly conserved regulatory proteins involved in diverse roles such as signal transduction, protein biosynthesis, cell adhesion, membrane remodeling and trafficking, cytoskeletal reorganization, apoptosis, autophagy, and cell motility. GTPases have such extensive function in cellular operation that they are called master regulators of intracellular membrane traffic (Stenmark 2009).
GTPase inhibitors are attractive drug discovery targets. Because of their biological roles, GTPase inhibitors are explored for use in a multitude of diseases, such as cancers and neurodegenerative diseases. Finding therapeutic methods to reign in overactivity requires selective technologies that can help assess the ability to interact with the target.
The Transcreener GDP GTPase Assay is an excellent tool for researchers examining GTPases for therapeutic treatments.