NUDIX hydrolases, a superfamily of enzymes, hydrolyze modified nucleoside diphosphates. NUDT1 is one of the most well-studied NUDIX hydrolases with correlation to several disorders including Parkinson's disease and cancer. NUDT5 recently attracted interest due to linkage to some human malignancies. NUDT5 hydrolyzes 8-OH-dGDP, 8-OH-dADP, and ADP-ribose (ADPR) along with other substrates.
High amounts of NUDT1 and NUDT5 correlate with non-small-cell lung cancer (NSCLC) cell lines and tissues, and greater levels of both proteins in NSCLC patients link to tumor metastasis. NUDT5 expression elevates in human breast cancer cell lines and breast tumor tissues. High NUDT5 expression profiles exhibit significantly poorer prognoses than lower NUDT5 levels.
The Transcreener AMP2 Assay is an excellent tool for researchers examining the therapeutic effects of NUDT5.