p97 has been associated with a variety of diseases, including neurodegenerative diseases, cancers, and viral infections. It plays an important role as a regulator of endoplasmic reticulum-associated degradation (ERAD), mitochondrial-associated degradation, chromatin-associated degradation, and more. Over-expression of p97 correlates to many cancers, while p97 mutations correlate to many neurodegenerative disorders (Huryn et al, 2020).
Because of its correlation to several viruses, cancers, and neurodegenerative disorders, researchers search for p97 modulators as targets for these diseases. The Transcreener p97 Assay makes screening and profiling for modulators easy and accurate in order to accelerate the discovery of therapeutic treatments.