The Transcreener WRN Exonuclease Assay determines enzyme activity by directly measuring dAMP formed by the enzyme using the Transcreener dAMP Exonuclease Assay. This biochemical HTS assay provides a universal method to assess the activity of virtually any exonuclease that produces dAMP.
Transcreener dAMP technology uses polyclonal mouse antibodies that selectively bind to dAMP and a far-red fluorescent tracer. dAMP produced displaces the tracer, changing the fluorescent properties and providing a fluorescent readout.
The WRN exonuclease assay is an easy-to-use, mix-&-read, HTS-ready assay that yields robust results. All you need to do is perform the enzyme reaction, add Transcreener reagents, and read your plates. It is available with an FP fluorescent readout.