A Guide to Measuring Drug-Target Residence Times with Biochemical Assays
During drug development initiatives, analysis of drug-target residence times can improve efficacy, increase therapeutic window, and reduce the risk of premature focus on candidate compounds that are likely to have undesirable side effects. This guide provides technical background on concepts and techniques for use of Transcreener® biochemical assays to measure drug-target residence times, along with examples and case studies.
Jump-Dilution Method to Measure Residence Time
Learn more including:
- The basics of residence time and its importance to drug discovery
- A comparison of methods used for residence time determination
- Using the jump-dilution method with Transcreener biochemical assays
- Data analysis used to accurately determine residence time
- Examples of measuring residence time for kinases, phosphodiesterases, and glycosyltransferases
Enter your contact info and learn how to determine drug-target residence times and improve your lead discovery with this 12-page guide!