BellBrook Labs provides a variety of drug discovery services including biochemical assay development and lead discovery to advance your target into a lead candidate faster and with confidence.

BellBrook’s drug discovery services specialize in small molecule inhibitors / activators for enzyme drug targets. We have been conducting assay development and lead discovery for over 15 years. During this time our experts have worked diligently with a variety of customers in their early-stage drug discovery programs.

From assay development to lead discovery, we can provide quality data to help accelerate your discovery program.

Assay Development Services

  • Assay Development – Custom Assay Development
  • Target Protein Sourcing/Production
  • Assay Optimization with Target Protein
  • Assay Validation – Pilot Screens, Interference Screens
Assay Development Services

Lead Discovery Services

  • Inhibitor Screening – To identify or confirm activity with the target.
  • Inhibitor Potency Profiling – Dose-response with target and/or related proteins. Fast IC50 results.
  • Residence Time Measurements – Determination of koff using ‘jump dilution’ enzymatic assay method.
  • Mechanism of Action Studies – Kinetic analysis to define the mode of inhibition.

Example Target Families

  • Protein Kinases
  • Lipid Kinases
  • Carbohydrate Kinases
  • ATPases
  • Acetyltransferases
  • HDACs
  • GTPases, GAPs, GEFs
  • Phosphodiesterases
  • Helicases
  • Ligases/Synthetases
  • Glycosyltransferases

Accelerating the Drug Discovery Process

Contact Us to Learn More About Drug Discovery Services

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