BellBrook Labs provides a variety of drug discovery services including biochemical assay development and lead discovery to advance your target into a lead candidate faster and with confidence.
BellBrook’s drug discovery services specialize in small molecule inhibitors / activators for enzyme drug targets. We have been conducting assay development and lead discovery for over 15 years. During this time our experts have worked diligently with a variety of customers in their early-stage drug discovery programs.
From assay development to lead discovery, we can provide quality data to help accelerate your discovery program.
Assay Development Services
- Assay Development – Custom Assay Development
- Target Protein Sourcing/Production
- Assay Optimization with Target Protein
- Assay Validation – Pilot Screens, Interference Screens
Lead Discovery Services
- Inhibitor Screening – To identify or confirm activity with the target.
- Inhibitor Potency Profiling – Dose-response with target and/or related proteins. Fast IC50 results.
- Residence Time Measurements – Determination of koff using ‘jump dilution’ enzymatic assay method.
- Mechanism of Action Studies – Kinetic analysis to define the mode of inhibition.
Example Target Families
- Protein Kinases
- Lipid Kinases
- Carbohydrate Kinases
- ATPases
- Acetyltransferases
- HDACs
- GTPases, GAPs, GEFs
- Phosphodiesterases
- Helicases
- Ligases/Synthetases
- Glycosyltransferases
