Helicases as Powerful Tools in Innate Immunity
Monday, 11 July 2022
Helicases are among the largest and most highly conserved families of enzymatic proteins in eukaryotic organisms. These proteins utilize NTP hydrolysis (usually ATP) to drive their recognition, remodeling, and response to target DNA or RNA.1 Nearly every aspect of nucleic acid metabolism is mediated by helicases. DNA helicases function in replication, repair, recombination, transcription, chromosome
- Published in Emerging Targets, HTS Assays, Innate Immunity
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Resolving the Many Roles of DHX36
Wednesday, 27 April 2022
While most researchers are familiar with canonical DNA structures, primarily B (but also even A or Z) DNA, an even more exotic form exerts a vast influence over nearly every aspect of nucleic acid function. In both DNA and RNA, tracts of guanine with at least four consecutive members can self-associate via Hoogsten base pairing
- Published in Emerging Targets, HTS Assays, Innate Immunity