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Tag: drug discovery services

Five Considerations When Choosing a Biochemical Assay Development Services CRO

Monday, 28 September 2020 by Bellbrook Labs
Assay Development Services - Two Scientists Working In the Lab
There are many options out there for choosing assay development services, and finding what you need can be a challenging endeavor. Here we outline five items to look for when searching for the CRO that is right for your project. To narrow things down a bit, this article will focus on biochemical assay development services
Assay Development Servicesdrug discovery servicesLead Discovery Services
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A Novel Approach Discovers Hundreds of Cancer-Relevant Arginine Methylation Sites for CARM1

Thursday, 14 December 2017 by Bellbrook Labs
Protein arginine methylation is an important post-translational modification, but its impact remains rather mysterious. Approximately 7% of all arginine residues in the human proteome are modified by mono- or di-methylation (which is a similar order of magnitude to the 9% of serine residues that are phosphorylated and the 7% of lysine residues that are ubiquitinated).¹
AptaFluor SAH Methyltransferase AssayAssay Development Servicesdrug discovery servicesEPIGEN Methyltransferase Assaymethyltransferase
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  • Published in Epigenetics, HTS Assays, Products, Uncategorized
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Doubling the Odds: Two-Pronged Strategy to Halt Cancer Cell Proliferation

Wednesday, 29 November 2017 by Bellbrook Labs
It would be difficult to underestimate the importance of polo-like kinase 1 (Plk1) for cancer, given its influence on cell division. As one of five members of the Polo-like family of serine/threonine protein kinases in eukaryotic cells, Plk1 plays a multifaceted role in the cell cycle and thus controls cancer progression fueled by unchecked cell
Assay Development Servicesdrug discovery serviceskinase assayTranscreener ADP Kinase Assay
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  • Published in HTS Assays, News, Uncategorized
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Newly Patented Aurora A Kinase Inhibitor a Promising Contender for Cancer Treatment

Wednesday, 15 November 2017 by Bellbrook Labs
Aurora A Kinase in Cancer Drug Development Aurora A Kinase, along with -B and -C, are members of a family of serine/threonine protein kinases that play critical roles in coordinating mitosis, including establishment of the mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. The enzyme’s role
Assay Development Servicesdrug discovery serviceskinase assayLead Discovery ServicesTranscreener ADP Kinase Assay
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Using the Transcreener® GDP Assay to Discern the Truth about Dynamin Inhibitors

Thursday, 19 October 2017 by Bellbrook Labs
Imagine viewing the plasma membrane of a cell from an interior perspective, with a front-row seat to the process by which substances enter the cell. Over in one corner, the plasma membrane begins to bulge inward, forming a sphere stretching toward you with a droplet-shaped neck on the opposite side that remains connected to the
Assay Development Servicesdrug discovery servicesLead Discovery ServicesTranscreener GDP Assay
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New Posters from DOT 2017

Friday, 29 September 2017 by Bellbrook Labs
Poster Presentations A Homogenous, High Throughput Assay to Measure Guanine Nucleotide Exchange Factor Activity Using Transcreener® GDP Assay Guanine nucleotide exchange factors (GEFs) positively regulate Rho GTPases by accelerating GDP dissociation to allow formation of the active, GTP-bound complex. Development of inhibitors that specifically disrupt GEF action on a target Rho GTPase may be a
AptaFluor SAH Methyltransferase AssayAssay Development Servicesdrug discovery servicesLead Discovery ServicesTranscreener AMP/GMP AssayTranscreener cGAMP cGAS AssayTranscreener GDP Assay
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  • Published in HTS Assays, News
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Taking Up Residence: Using the Transcreener ADP Assay to Measure the Kinetics of Kinase Inhibitor Interactions

Wednesday, 30 August 2017 by Bellbrook Labs
Classically speaking, assays for interactions between drug molecules and their targets have measured binding affinity under equilibrium conditions. In drug discovery projects, it had long been assumed that carefully measuring IC50 (half-maximal inhibitory concentration), EC50 (effector concentration for half-maximal response), Kd  (equilibrium dissociation constant), and/or Ki (inhibition constant) would allow drug candidates to be prioritized
Assay Development Servicesdrug discovery serviceskinase assayLead Discovery ServicesResidence TimeTranscreener ADP Kinase Assay
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BellBrook Labs Awarded NIH Grant to Develop a High Throughput cGAS Assay for Cancer and Autoimmune Disease Drug Discovery

Wednesday, 14 June 2017 by Bellbrook Labs
BellBrook Labs was recently awarded a $288,000 SBIR Phase I grant from the National Institutes of General Medical Sciences (NIGMS) to develop an HTS assay for cyclic GAMP synthase, an enzyme that triggers immune responses to viruses and tumors. The new assay will be used in an effort to screen for cGAS enzyme modulators as
Assay Development Servicesdrug discovery servicesLead Discovery ServicesTranscreener cGAMP cGAS Assay
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  • Published in Emerging Targets, HTS Assays, News
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Ectonucleotidases: An Outside Chance for Drug Development

Friday, 28 April 2017 by Bellbrook Labs
Sometimes, the most intriguing cellular processes happen outside of the cell. Case in point: purinergic signaling pathways, in which extracellular receptors sense levels of purines in the extracellular milieu. The result? A wide array of effects on neuronal signaling, vascular tone, thrombosis, and immune function. But what controls the level of extracellular purines? Enter ectonucleotidases:
Assay Development Servicesdrug discovery servicesLead Discovery ServicesTranscreener ADP Kinase AssayTranscreener AMP/GMP Assay
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  • Published in Emerging Targets, HTS Assays, Uncategorized
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New Publication: HTS Method for Measuring Drug Residence Time

Tuesday, 25 April 2017 by Bellbrook Labs
View our latest publication, “A High-Throughput Method for Measuring Drug Residence Time Using the Transcreener® ADP2 Assay” in SLAS Discovery. Inhibitor residence times are increasingly being used to prioritize molecules early in lead discovery programs. Current methods for determining residence time are low-throughput or require the synthesis of labeled ligands. Our goal was to create
Assay Development Servicesdrug discovery servicesLead Discovery ServicesResidence TimeTranscreener ADP Kinase AssayTranscreener AMP/GMP AssayTranscreener GDP AssayTranscreener UDP Assay
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