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Tag: EPIGEN Methyltransferase Assay

A Novel Approach Discovers Hundreds of Cancer-Relevant Arginine Methylation Sites for CARM1

Thursday, 14 December 2017 by Bellbrook Labs
Protein arginine methylation is an important post-translational modification, but its impact remains rather mysterious. Approximately 7% of all arginine residues in the human proteome are modified by mono- or di-methylation (which is a similar order of magnitude to the 9% of serine residues that are phosphorylated and the 7% of lysine residues that are ubiquitinated).¹
AptaFluor SAH Methyltransferase AssayAssay Development Servicesdrug discovery servicesEPIGEN Methyltransferase Assaymethyltransferase
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  • Published in Epigenetics, HTS Assays, Products, Uncategorized
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EZH2 Methyltransferase Inhibitors Hold Promise for Combating Neuropathic Pain

Friday, 21 July 2017 by Bellbrook Labs
When people experience neuropathic pain, they often describe “pins and needles” sensations or burning, shooting, or stabbing pain that can be agonizing and difficult to bear. In some cases, neuropathic pain is so intense that the pressure of clothing or the weight of a bed sheet can cause misery. Chronic neuropathic pain can be caused
AptaFluor SAH Methyltransferase AssayAssay Development ServicesEPIGEN Methyltransferase AssayLead Discovery Servicesmethyltransferase
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  • Published in Emerging Targets, Epigenetics, HTS Assays
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Inhibition of Methyltransferase SMYD3 Targets Ras-driven Cancers

Wednesday, 04 May 2016 by Hannah Lucas
The methyltransferase SMYD3 is overexpressed in several tumor types, and its overexpression correlates with aggressiveness in breast carcinoma.    Its epigenetic role has been investigated extensively: SMYD3 methylates histone H4 at K5, stimulating expression of critical oncogenic proteins that drive cell proliferation, invasion and metastasis.  However, it has recently been discovered that SMYD3 also methylates non-histone
AptaFluor SAH Methyltransferase AssayEPIGEN Methyltransferase Assaymethyltransferasetumor suppressor
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  • Published in Emerging Targets
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Transcreener® Assays Help Feed Epigenetics Drug Pipeline Down Under

Thursday, 25 February 2016 by Edna.Kunkel
Cancer Research Technology (CRT), the development and commercialization arm of Cancer Research UK, recently announced a licensing agreement with Merck (MSD) to develop and commercialize protein arginine methyltransferase 5 (PRMT5) inhibitors. CRT, a subsidiary of Cancer Research UK, entered into this agreement with MSD (Germany) on behalf the Australian Cooperative Research Center for Cancer Therapeutics
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  • Published in Emerging Targets, Epigenetics, Success Stories
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Digging into Dopamine Signaling: Arginine Methylation Regulates GPCRs

Monday, 25 January 2016 by Robyn Perrin
The neurotransmitter dopamine is one of the most fascinating substances regulating behavior, with both delightful and dark qualities. Affecting a mere 20,000 dopamine-responsive neurons out of 100 billion neurons in the human brain, dopamine nonetheless governs critical aspects of our existence including voluntary movement, psychosis, and addiction. Disrupted dopamine signaling is involved in maladies ranging
AptaFluor SAH Methyltransferase Assaydopamine receptor signalingEPIGEN Methyltransferase AssayG protein-coupled receptorsGPCRmethyltransferasePRMT5
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  • Published in Emerging Targets
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Preparing for the Epigenevitable

Tuesday, 14 July 2015 by Robert Lowery
Epigenetic drug discovery has generated a lot of excitement in the past few years, and many stakeholders are eagerly awaiting clinical results for the first two histone methyltransferase (HMT) inhibitor drugs, which target Dot1L and EZH2. The analogies with kinase drug discovery, i.e., targeting oncogenic gain-of-function driver mutations in enzymes that catalyze post-translational modifications, helped
AptaFluor SAH Methyltransferase AssayEPIGEN Methyltransferase Assay
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  • Published in Epigenetics
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New Publication: Optimizing Histone Methyltransferase Assays

Tuesday, 09 June 2015 by Edna.Kunkel
See our latest publication, “Biochemical Assay Development for Histone Methyltransferases Using a Transcreener-Based Assay for S-Adenosylhomocysteine” in Assay and Drug Development Technologies Screening or profiling histone methyltransferases (HMTs) can often require challenging assay development. Their complex enzyme and substrate requirements compound the difficulties imposed by their unusual (read SLOW) kinetic properties. In a recent study
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  • Published in News
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DNA Methylation Modulates Alcohol Addiction

Wednesday, 13 May 2015 by Jvardas
Alcoholism is a multifaceted disorder caused by both genetic and environmental influences and epigenetic modifications, including histone acetylation and DNA methylation, have been shown to control alcohol-related behaviors. In a recent study, Estelle Barbier, from Linköping University in Sweden, collaborated with scientists at NIH to begin to understand how DNA methylation contributes to the lasting
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  • Published in Epigenetics
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Ensuring Assay Success: The Right Plate Makes All The Difference

Thursday, 19 June 2014 by katie.lowery
Transcreener® HTS Assays rely on direct immunodetection of nucleotides with a far-red readout in a simple mix-and-read format.  The assays are available in three different detection modes, fluorescence polarization (FP), fluorescence intensity (FI), and time-resolved Forster resonance energy transfer (TR-FRET).  A good microplate reader and the right choice of plates to differentiate specific signal versus
AptaFluor SAH Methyltransferase AssayEPIGEN Methyltransferase AssayTranscreener ADP Kinase AssayTranscreener AMP/GMP AssayTranscreener GDP AssayTranscreener UDP Assay
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  • Published in HTS Assays
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Epigenetics: Making Bad Memories a Thing of the Past?

Thursday, 06 February 2014 by katie.lowery
Traumatic events generate some of the most enduring forms of memories.  Extreme physical or psychological harm often leads to the development of PTSD or other fear and anxiety-related disorders.  Not only are these memories intensely painful, they are also extremely difficult to treat with behavioral therapy.  A recent study by a group of researchers based
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  • Published in Epigenetics
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