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Tag: epigenetics

BellBrook Labs Launches Ultra-Sensitive Methyltransferase Assay to Accelerate Epigenetic Drug Discovery

Thursday, 10 August 2017 by Bellbrook Labs
Methyltransferases have become a major focus of drug discovery for cancer and other diseases driven by epigenetic factors.  BellBrook Labs’ new, ultra-sensitive AptaFluor™ SAH Methyltransferase Assay eliminates cost and sensitivity barriers that are slowing the discovery of methyltransferase inhibitors. New AptaFluor SAH Methyltransferase Assay Schematic BellBrook Labs announces the launch of their latest drug discovery
AptaFluor SAH Methyltransferase AssayAssay Development ServicesepigeneticsLead Discovery Servicesmethyltransferase
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  • Published in Epigenetics, News, Uncategorized
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Previously Recorded Webinar – The New AptaFluor™ SAH Methyltransferase Assay: A Homogenous, Universal Assay Based on a Microbial Riboswitch

Monday, 31 July 2017 by Bellbrook Labs
Epigenetic regulation has been shown to be a contributing factor in a variety of diseases, and discovery of methyltransferase inhibitors is an area of intense activity. Methyltransferase enzymes methylate a variety of substrates using S-adenosylmethionine (SAM) as the methyl donor leaving S-adenosylhomocysteine (SAH) as a common product. Since the difference between SAH and SAM is
AptaFluor SAH Methyltransferase Assayepigeneticsmethyltransferase
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  • Published in Epigenetics, HTS Assays, Products
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Creating a Methyltransferase HTS Assay Using an SAH Riboswitch Part II

Wednesday, 19 October 2016 by Bellbrook Labs
In Part I of II in this blog series, discussion included the challenges of screening methyltransferases, steps in developing an SAH assay, the experimental assay procedure, assay sensitivity, and reagent stability. Please view the previous post here: Creating a Methyltransferase HTS Assay Using an SAH Riboswitch Part I. Compatibility with Diverse MT Accepter Substrates As
AptaFluor SAH Methyltransferase AssayAssay Development Servicesdrug discovery servicesepigeneticsLead Discovery Services
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  • Published in Epigenetics, HTS Assays, Products
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Creating a Methyltransferase HTS Assay Using an SAH Riboswitch Part I

Friday, 23 September 2016 by Bellbrook Labs
Riboswitches were discovered in 2002 by Ron Breaker at Yale as RNA-based intracellular sensors of vitamin derivatives. During the last decade, riboswitches have been identified that bind a range of small biomolecules including nucleotides, amino acids, and ions. Riboswitches exert regulatory control of transcription, translation, splicing, and RNA stability. BellBrook scientists used a riboswitch that
AptaFluor SAH Methyltransferase AssayAssay Development Servicesdrug discovery servicesepigeneticsLead Discovery Services
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  • Published in Epigenetics, HTS Assays, Products
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