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Tag: Helicase Assay

DDX6 Regulates mRNA Transcription & Translation Pathways

Monday, 10 July 2023 by Bellbrook Labs
DDX6 regulates RNA transcription and translation
DDX6 (RCK/p54) was first isolated from the RC-K8 B-cell lymphoma line over 30 years ago. This 472 amino acid, 53.2 kDa “DEAD-Box” ATP-dependent RNA helicase bears the signature Asp-Glu-Ala-Asp motif, characteristic of all DEAD box proteins. Dead box proteins contain both ATPase and helicase activity, and are known for their particular protein-protein and RNA-protein interactions
cancerDDX6Helicase AssayInnate Immunityneurodegenerative diseaseTranscreener ADP Assayviral infections
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  • Published in Emerging Targets, HTS Assays, Innate Immunity, Neurodegenerative Diseases
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Targeting DDX5 Inhibitors to Battle Cancers & Viral Infections

Monday, 12 June 2023 by Bellbrook Labs
DDX5 Inhibitors Targeting Colon Cancer
DDX5 (Dead-Box 5 or p68) is a member of a family of 37 “DEAD-Box” ATP-dependent RNA helicases that play a role in nearly all aspects of RNA processing and also act as nucleic acid recognition receptors for viral immunity. Dysregulation and/or overexpression of DDX5 can lead to tumor progression. It can also be hijacked by
cancerDDX5Helicase AssayInnate ImmunitySARS-CoVTranscreener ADP Assayviral infections
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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Helicases as Powerful Tools in Innate Immunity

Monday, 11 July 2022 by Bellbrook Labs
Helicases Used in Innate Immunity
Helicases are among the largest and most highly conserved families of enzymatic proteins in eukaryotic organisms. These proteins utilize NTP hydrolysis (usually ATP) to drive their recognition, remodeling, and response to target DNA or RNA.1 Nearly every aspect of nucleic acid metabolism is mediated by helicases. DNA helicases function in replication, repair, recombination, transcription, chromosome
DDX41DHX36Helicase AssayTranscreener ADP Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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Resolving the Many Roles of DHX36

Wednesday, 27 April 2022 by Bellbrook Labs
DHX36 RNA Helicase Unwinds G4 RNA Structures
While most researchers are familiar with canonical DNA structures, primarily B (but also even A or Z) DNA, an even more exotic form exerts a vast influence over nearly every aspect of nucleic acid function. In both DNA and RNA, tracts of guanine with at least four consecutive members can self-associate via Hoogsten base pairing
DHX36Helicase AssayTranscreener ADP Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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NSP13 Inhibitors for the Potential Treatment of COVID-19

Monday, 14 June 2021 by Bellbrook Labs
NSP13 Inhibitors as COVID-19 Treatments
Could NSP13 be the target to help treat some respiratory infections such as SARS-CoV-2? Respiratory diseases caused by coronaviruses (CoVs) vary in symptoms, severity, and risk. Typically, symptoms are mild and known as the common cold, while others are more severe and lead to pneumonia or bronchitis, chest pains, and possibly death. SARS-CoV and MERS-CoV
Helicase AssayNSP13 InhibitorsTranscreener ADP ATPase Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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