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Tag: Innate Immunity

DDX6 Regulates mRNA Transcription & Translation Pathways

Monday, 10 July 2023 by Bellbrook Labs
DDX6 regulates RNA transcription and translation
DDX6 (RCK/p54) was first isolated from the RC-K8 B-cell lymphoma line over 30 years ago. This 472 amino acid, 53.2 kDa “DEAD-Box” ATP-dependent RNA helicase bears the signature Asp-Glu-Ala-Asp motif, characteristic of all DEAD box proteins. Dead box proteins contain both ATPase and helicase activity, and are known for their particular protein-protein and RNA-protein interactions
cancerDDX6Helicase AssayInnate Immunityneurodegenerative diseaseTranscreener ADP Assayviral infections
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  • Published in Emerging Targets, HTS Assays, Innate Immunity, Neurodegenerative Diseases
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Targeting DDX5 Inhibitors to Battle Cancers & Viral Infections

Monday, 12 June 2023 by Bellbrook Labs
DDX5 Inhibitors Targeting Colon Cancer
DDX5 (Dead-Box 5 or p68) is a member of a family of 37 “DEAD-Box” ATP-dependent RNA helicases that play a role in nearly all aspects of RNA processing and also act as nucleic acid recognition receptors for viral immunity. Dysregulation and/or overexpression of DDX5 can lead to tumor progression. It can also be hijacked by
cancerDDX5Helicase AssayInnate ImmunitySARS-CoVTranscreener ADP Assayviral infections
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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[Webinar] Targeting DNA Damage Repair for Drug Discovery Using the Transcreener ADPR® Assay

Thursday, 04 May 2023 by Bellbrook Labs
Preview of DNA Damage Repair Webinar
Interested in DNA damage repair pathways for drug discovery? Join us for a live webinar, where Ha Pham, senior scientist at BellBrook Labs, will be sharing her expertise on using the Transcreener ADPR Assay, a biochemical HTS assay, to study enzymes involved in DNA damage repair. She will use CD38 and PARG as target examples
ADPR AssayCD38CD38 AssayDNA Damage RepairInnate ImmunityPARGWebinar
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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Transcreener® ADP2 Assay Delivers Precise Measurement of Functional MAPK14 Residence Time

Monday, 01 May 2023 by Bellbrook Labs
Calculating MAPK14 Residence Time
Researchers at the University of Tubingen use Transcreener to uncover how residence time works on a molecular level with p38α MAPK Inhibitors – Many factors affect the effectiveness of ligand-substrate or drug-target interactions. Conformational docking and stearic considerations help inform optimal “fits.” Ligand moiety solubility, both in free and bound forms, is also a consideration
cancerinflammatory diseaseInnate Immunitykinase assayKinase Assay KitMAPK14neurodegenerative diseaseResidence TimeTranscreener ADP Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity, Products, Success Stories
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DDX1: A Versatile RNA Helicase

Tuesday, 18 April 2023 by Bellbrook Labs
DDX1 as a versatile RNA Helicase
DDX1 (Dead-Box Helicase 1) belongs to the DEAD-Box family of ATP-dependent RNA helicases, whose members are collectively involved in almost all aspects of RNA processing: from transcription to remodeling to degradation. They are named for the central Asp-Glu-Ala-Asp (DEAD) sequence they all possess. The 35 human DEAD-Box proteins comprise the largest family of helicases known.
ATPasecancerDDX1hyperlipidemiaInnate ImmunityTranscreener ADP ATPase Assay
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  • Published in Emerging Targets, Innate Immunity
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Investigating RAB2 as a Vesicle Transporter & Autophagy Initiator

Tuesday, 04 April 2023 by Bellbrook Labs
RAB2 Transports Membrane Bound Vesicles
RAB2 is part of the RAB family of small GTPases that regulate intracellular trafficking of membrane bound vesicles. It is highly conserved in eukaryotes, from C. elegans to humans. These GTPases influence the creation, movement, attachment, fusion, and destiny of vesicles originating in the endoplasmic reticulum (ER)/Golgi systems. Like other members of its family, RAB2
cancerhyperglycemiaInnate Immunityneurological diseaseRAB2Transcreener GDP Assay
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  • Published in Emerging Targets, Innate Immunity
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Is PARP1 a Hero or Villain?

Tuesday, 07 March 2023 by Bellbrook Labs
PARP1 as a Hero vs Villain
Not counting histones, PARP1 [Poly(ADP-ribose) Polymerase 1] is the most abundant nuclear protein in mammalian cells. While principally known for its role in various types of DNA repair, recent work expanded it’s repertoire to include genome stability maintenance, chromatin remodeling, DNA methylation/gene expression, cellular differentiation, and cell survival modulation via NAD+/ATP regulation.1 It performs Poly(ADP-ribosyl)ation
cancerDNA repairInnate Immunityneurological diseasePARP1
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  • Published in Emerging Targets, Innate Immunity
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Advancements in The Ongoing Puzzle to Understand c-SRC

Tuesday, 21 February 2023 by Bellbrook Labs
Ongoing Puzzle of c-SRC in Cancer Treatment
Nearly a half-century ago, sequences from the Rous Sarcoma Virus were used to identify the first proto-oncogene and the first of a family of non-receptor tyrosine kinases: c-SRC. Unlike its viral counterpart (v-SRC), c-SRC exists in both an active and inactive state. It is produced in almost every cell type, but expressed highest in the
c-SRCInnate ImmunityKinaseOncogenetyrosine kinase inhibitors
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  • Published in Emerging Targets, Innate Immunity
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The Challenging Search for BTK Inhibitors

Tuesday, 27 December 2022 by Bellbrook Labs
BTK's Involved in Systemic lupus erythematosus
Bruton’s Tyrosine Kinase (BTK) is a 76kDa non-receptor Tec kinase that plays numerous diverse roles in B-cell development, immunity, autoimmunity, infection, and cancer. From stem to stern, it consists of an N-terminal plekstrin homology (PH) domain, a TEC homology (TH) domain, two SRC homology (SH2 and SH3) domains, and a C-terminal kinase domain. Unlike SRC,
Autoimmune DiseaseBTKInnate Immunitykinase assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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SARM1 Forefronts Research into Major Neurological Diseases

Monday, 19 December 2022 by Bellbrook Labs
SARM1 Causes Axonal Death
SARM1 [Sterile alpha & toll/interleukin receptor (TIR) motif-containing protein 1] consists of a N-terminal mitochondrial localization sequence (NLS), an autoinhibitory HEAT/armadillo (ARM) domain, two tandem sterile alpha motif domains (SAMs), and a C-terminal toll/interleukin receptor domain (TIR). It is a human toll like receptor (TLR) adaptor protein. TLR adaptors (MYD88, MAL, TRIF, & TRAM) usually
Innate Immunityneurodegenerative diseaseneurological diseaseneuronal cell deathSARM1
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  • Published in Emerging Targets, Innate Immunity, Neurodegenerative Diseases
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Recent Posts

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  • DDX6 regulates RNA transcription and translation

    DDX6 Regulates mRNA Transcription & Translation Pathways

    DDX6 (RCK/p54) was first isolated from the RC-K...
  • Scientist using Transcreener Assay to Study PIK3CA Mutation

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    The PIK3CA gene codes for the 110 kDa catalytic...
  • DDX5 Inhibitors Targeting Colon Cancer

    Targeting DDX5 Inhibitors to Battle Cancers & Viral Infections

    DDX5 (Dead-Box 5 or p68) is a member of a famil...

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