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Tag: Kinase Assay Kit

The Role of ALPK1 in Health and Disease

Thursday, 12 May 2022 by Bellbrook Labs
Scientist Studying ALKPK1
ALPK1 (Alpha Kinase 1) is an atypical serine/threonine-protein kinase that specifically detects and binds the pathogen-associated pattern metabolites (PAMPs), ADP-beta-D-manno-heptose (Beta-ADP-Heptose) or D-glycero-beta-D-manno-heptose 1,7-bisphosphate (HBP). These metabolic precursors of lipopolysaccharide (LPS) biosynthesis are present in all Gram-negative and some Gram-positive bacteria.  This interaction stimulates ALPK1 to phosphorylate and activate TIFA, initiating an innate immune response
ALPK1Kinase Assay Kit
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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A Kinase Assay Kit to Interrogate Innate Immunity Targets

Thursday, 15 April 2021 by Bellbrook Labs
Performing a Kinase Assay Kit in a Lab
Kinases are essential players in cellular functions such as cell signaling, cellular transport, and protein regulation. For these reasons, many kinases are innate immunity targets. A kinase assay kit is ideal whether used for drug screening and dose-response measurements or detection when studying a particular cellular pathway. A universal ADP assay allows researchers to screen
Kinase Assay KitTranscreener ADP Kinase Assay
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  • Published in HTS Assays, Products
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Uncovering IRAK4 Inhibitors with a Transcreener Kinase Assay Kit

Friday, 23 October 2020 by Bellbrook Labs
Lab IRAK4 Inhibitors Kinase Assay Kit
Genentech discovers IRAK4 inhibitors using the Transcreener Kinase Assay Kit – IRAK is also known as Interluekin-1 Receptor Associated Kinase. There are four different proteins within this group, including IRAK1, IRAK2, IRAK3, and IRAK4. Each of these mediates interaction with MyD88 and its associated adaptor proteins. IRAK1 and IRAK4 are active enzymes that exhibit kinase
IRAk1IRAK4Kinase Assay KitTranscreener ADP Kinase Assay
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  • Published in Success Stories
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