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Tag: kinase assay

Transcreener® ADP2 Assay Delivers Precise Measurement of Functional MAPK14 Residence Time

Monday, 01 May 2023 by Bellbrook Labs
Calculating MAPK14 Residence Time
Researchers at the University of Tubingen use Transcreener to uncover how residence time works on a molecular level with p38α MAPK Inhibitors – Many factors affect the effectiveness of ligand-substrate or drug-target interactions. Conformational docking and stearic considerations help inform optimal “fits.” Ligand moiety solubility, both in free and bound forms, is also a consideration
cancerinflammatory diseaseInnate Immunitykinase assayKinase Assay KitMAPK14neurodegenerative diseaseResidence TimeTranscreener ADP Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity, Products, Success Stories
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The Challenging Search for BTK Inhibitors

Tuesday, 27 December 2022 by Bellbrook Labs
BTK's Involved in Systemic lupus erythematosus
Bruton’s Tyrosine Kinase (BTK) is a 76kDa non-receptor Tec kinase that plays numerous diverse roles in B-cell development, immunity, autoimmunity, infection, and cancer. From stem to stern, it consists of an N-terminal plekstrin homology (PH) domain, a TEC homology (TH) domain, two SRC homology (SH2 and SH3) domains, and a C-terminal kinase domain. Unlike SRC,
Autoimmune DiseaseBTKInnate Immunitykinase assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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Can WRN Helicase Inhibitors Treat MSI-H Cancers?

Tuesday, 04 October 2022 by Bellbrook Labs
Patient With WRN Helicase Syndrome
Over 100 years ago, Otto Werner first characterized a recessive autosomal disorder that caused premature, but largely typical, aging in adults, starting by the 3rd decade and resulting in death by the 6th decade via myocardial infarction or cancer. This disease, now known as Werner syndrome, is caused by specific alterations in the 162 KDa
Innate Immunitykinase assayWRN Helicase
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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Webinar: Targeting Kinases Involved in the Innate Immune Response

Wednesday, 13 October 2021 by Bellbrook Labs
Abstract: Clinical trials continue to determine whether therapeutic modulation of kinases can be used to suppress the immune system in autoimmune diseases or stimulate for antiviral and cancer immunotherapy. The discovery and characterization of small molecule modulators have aided these efforts. The Transcreener ADP² Kinase Assay meets this need as it relies on direct ADP
Innate Immunitykinase assayTranscreener ADP Kinase Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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IKK Complex, NF-kB, and Inflammation – An Intricate Relationship

Tuesday, 07 September 2021 by Bellbrook Labs
IKK Complex & Inflammation
Components of the IKK Complex The IκB kinase (IKK) complex consists of two catalytic subunits IKKα (IKK1) and IKKβ (IKK2), as well as a non-catalytic accessory protein IKKγ. IKKγ is also known as NF-κB essential modulator (NEMO). IKKα and IKKβ have high sequence homology and hence, are structurally similar. Both of those subunits possess phosphorylating
IKK Kinasekinase assayTranscreener ADP Kinase Assay
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  • Published in Emerging Targets, Innate Immunity
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Using a PKR Inhibitor Assay in the Fight Against Viruses

Tuesday, 01 June 2021 by Bellbrook Labs
PKR Inhibitor Blog
Can a novel PKR inhibitor help lead to new treatments for viral infections? –  While the human immune response is astounding and works hard to keep us alive in the face of the many germs we encounter daily, it is exceedingly complex. Unlike the adaptive immune response, the innate response acts quickly. It is considered
kinase assayPKR InhibitorTranscreener ADP Kinase Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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Transcreener Assay Used to Evaluate PI3K Inhibitors

Tuesday, 17 March 2020 by Bellbrook Labs
PI3K Inhibitors for Cancer Research
PI3K Inhibitors and Cancer – Although cancer is widespread, determining the culprit, as well as individual treatment, is challenging. A variety of cancer types exist with a multitude of contributors. Being the most common human genetic disease, a whole host of genes are involved. Some contribute to curbing cancer (tumor suppressor genes), while oncogenes promote
kinase assayPIK3Transcreener ADP Kinase Assay
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  • Published in Success Stories
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Transcreener ADP Assay Used to Discover RIPK1 Inhibitors

Tuesday, 18 February 2020 by Bellbrook Labs
RIPK1 Inhibitors Inflammatory disease treatment
Genentech discovers novel RIPK1 inhibitors – Like other serine/threonine protein kinases, receptor-interacting serine/threonine-protein kinase 1 (RIPK1) plays a role in several signaling pathways that keep us living healthy, functioning lives. RIPK1 is one of those enzymes’ that wears a variety of hats depending on what function needs attention. It contributes to cell death as well
kinase assayRIPK1 InhibitorsTranscreener ADP Kinase Assay
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  • Published in Success Stories
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Finding Inhibitors for a Cancer Target: CDK12 Activity Assays Accelerate the Search

Tuesday, 03 December 2019 by Bellbrook Labs
CDK12 Activity Assays Find Inhibitors Cancer Treatment
All systems within our bodies function by means of proteins. When these proteins aren’t made correctly, our body malfunctions.  The short explanation: DNA is at the fabric of forming a functional protein; genes (made of DNA) get transcribed and then translated to become proteins. During this complex process, genes are not always correctly transcribed and
CDK12 Activity Assayskinase assayTranscreener ADP Kinase Assay
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  • Published in Emerging Targets, HTS Assays
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Using TBK1 Inhibitors to Stop Cancer in Its Tracks

Tuesday, 29 October 2019 by Bellbrook Labs
Scientist Working on TBK1 Inhibitors for Cancer Research
TBK1 Inhibitors, Autoimmune Disorders, and Cancer – Inflammation is a crucial step within the immune response, helping our bodies eliminate disease. However, it can also be a burden where misregulation creates a variety of maladies including cancer. As inflammation persists, becoming chronic, the beneficial elements can be lost and disease occurs. It’s not just autoimmune
kinase assayTBK1 InhibitorsTranscreener ADP Kinase Assay
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  • Published in Emerging Targets
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Recent Posts

  • Preview of DNA Damage Repair Webinar

    [Webinar] Targeting DNA Damage Repair for Drug Discovery Using the Transcreener ADPR® Assay

    Interested in DNA damage repair pathways for dr...
  • Calculating MAPK14 Residence Time

    Transcreener® ADP2 Assay Delivers Precise Measurement of Functional MAPK14 Residence Time

    Researchers at the University of Tubingen use T...
  • DDX1 as a versatile RNA Helicase

    DDX1: A Versatile RNA Helicase

    DDX1 (Dead-Box Helicase 1) belongs to the DEAD-...
  • RAB2 Transports Membrane Bound Vesicles

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    RAB2 is part of the RAB family of small GTPases...
  • PARP1 as a Hero vs Villain

    Is PARP1 a Hero or Villain?

    Not counting histones, PARP1 [Poly(ADP-ribose) ...

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