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Tag: kinase assay

How Does a Biochemical Kinase Assay Work?

Monday, 10 December 2018 by Bellbrook Labs
What is a kinase assay
A kinase assay works by simply measuring the activity of the kinase. A kinase is an enzyme that aids in the transfer of a phosphate from ATP to another specific molecule. They regulate many activities in the human body. The measurement is used to test potential drugs to see how they affect kinase activity. An
kinase assay
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Transcreener ADP Assay Enables Evaluation of NIK Inhibitors in Lupus Drug Discovery

Wednesday, 07 November 2018 by Bellbrook Labs
Lupus NIK Inhibitor
  Systemic lupus erythematosus (SLE), or lupus, takes a devastating toll. An autoimmune disease that triggers a dysfunctional immune system to attack its own tissues, SLE strikes young women most often — about 4 to 12 times more frequently than men — with women aged 15 to 45 being at highest risk. Both genetic and
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Doubling the Odds: Two-Pronged Strategy to Halt Cancer Cell Proliferation

Wednesday, 29 November 2017 by Bellbrook Labs
It would be difficult to underestimate the importance of polo-like kinase 1 (Plk1) for cancer, given its influence on cell division. As one of five members of the Polo-like family of serine/threonine protein kinases in eukaryotic cells, Plk1 plays a multifaceted role in the cell cycle and thus controls cancer progression fueled by unchecked cell
Assay Development Servicesdrug discovery serviceskinase assayTranscreener ADP Kinase Assay
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Newly Patented Aurora A Kinase Inhibitor a Promising Contender for Cancer Treatment

Wednesday, 15 November 2017 by Bellbrook Labs
Aurora A Kinase in Cancer Drug Development Aurora A Kinase, along with -B and -C, are members of a family of serine/threonine protein kinases that play critical roles in coordinating mitosis, including establishment of the mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. The enzyme’s role
Assay Development Servicesdrug discovery serviceskinase assayLead Discovery ServicesTranscreener ADP Kinase Assay
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Taking Up Residence: Using the Transcreener ADP Assay to Measure the Kinetics of Kinase Inhibitor Interactions

Wednesday, 30 August 2017 by Bellbrook Labs
Classically speaking, assays for interactions between drug molecules and their targets have measured binding affinity under equilibrium conditions. In drug discovery projects, it had long been assumed that carefully measuring IC50 (half-maximal inhibitory concentration), EC50 (effector concentration for half-maximal response), Kd  (equilibrium dissociation constant), and/or Ki (inhibition constant) would allow drug candidates to be prioritized
Assay Development Servicesdrug discovery serviceskinase assayLead Discovery ServicesResidence TimeTranscreener ADP Kinase Assay
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Kinase Assays and Applications in Cancer Therapeutic Discovery

Wednesday, 30 November 2016 by Bellbrook Labs
The ABL1 gene is a special type of gene that encodes a protein tyrosine kinase. It is involved in various cellular processes, including but not limited to cell adhesion, cell division, and cell differentiation. This protein’s activity is adversely regulated by its SH3 domain, which involves the deletion of the region that encodes the domain
Kinasekinase assay
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ICBS Conference 2016

Thursday, 06 October 2016 by Bellbrook Labs
  Location: Madison, WI Date: October 24-26   BellBrook Labs’ team of scientists will be presenting the following posters at the International Chemical Biology Society. A Homogenous, Universal Methyltransferase Assay Based on a Microbial Riboswitch Leveraging Aptamers for Detection of Growth Factors in an HTS Compatible Format: An AptaFluor™ VEGF Assay Measuring Drug Residence Times
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Posters and Presentations from DOT 2016

Friday, 30 September 2016 by Bellbrook Labs
Did you miss the DOT 2016 meeting in Boston or would like a recap? View the posters and presentations from BellBrook’s scientists below. Posters: Aptamer Based Homogenous Single-Reagent HTS Assay Platform for Human Growth Factors Aniket, Elizabeth Vu, Meera Kumar, Tom Zielinski, Justin Brink, and Robert G. Lowery Determination of Drug Residence Time in a
Discovery on Targetkinase assaymethyltransferase
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Discovery on Target Conference 2016

Wednesday, 17 August 2016 by Bellbrook Labs
Discovery on Target 2016 September 19-22 Westin Boston Waterfront Boston, MA Exhibition Visit Booth #24 to: Discuss BellBrook’s current HTS assays. Share your thoughts on the future of drug discovery. Learn about upcoming AptaFluor™ HTS assays! Presentations/Talks AptaFluor™ Methyltransferase Assay: A Homogenous, Universal HMT Assay Based on a Microbial Riboswitch Tuesday, September 20th – 3:15PM Poster
Discovery on Targetkinase assaymethyltransferase
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View Our Kinase Inhibitor Residence Time Webinar Anytime!

Monday, 11 May 2015 by Edna.Kunkel
Analysis of inhibitor residence times is increasingly being incorporated into lead development efforts because longer engagement with the target can result in improved efficacy, increased therapeutic window and reduced side effects. Though residence time can be determined using immobilized ligand methods such surface plasmon resonance, conjugation of drugs can affect their binding. In this webinar,
kinase assayResidence TimeTranscreener ADP Kinase Assay
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Recent Posts

  • SLAS 2019

    BellBrook Labs Recap of SLAS 2019 in Washington DC.

    BellBrook Labs will be exhibiting and have post...
  • What is a kinase assay

    How Does a Biochemical Kinase Assay Work?

    A kinase assay works by simply measuring the ac...
  • Lupus NIK Inhibitor

    Transcreener ADP Assay Enables Evaluation of NIK Inhibitors in Lupus Drug Discovery

      Systemic lupus erythematosus (SLE), or l...
  • Histone Methylation PRMT4

    Sensitive Methyltransferase Assay Proves Successful with PRMT4

    Histone methyltransferases (HMTs) play a critic...
  • Acetyl CoA Carboxylase Inhibitors

    Acetyl-CoA Carboxylase Inhibitors: Transcreener ADP Assay Powers Drug Detection Strategy

    The impact of Acetyl-CoA carboxylases (ACCs) on...

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