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Tag: Lead Discovery Services

PRMT5 is Innately Interesting

Wednesday, 30 March 2022 by Bellbrook Labs
PRMT5 Role with Macrophages
PRMT5 is a type II arginine methyltransferase that dimethylates arginine residues symmetrically. Its various functions extend into T cell development, B cell regulation, hematopoiesis, and mitotic control. In the past, research on PRMT5 primarily focused on cancer and the adaptive immune response. These are both situations where metabolism and growth are critical. Recent reports implicate
AptaFluor SAH Methyltransferase AssayLead Discovery ServicesPRMT5
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  • Published in Emerging Targets, Epigenetics, Innate Immunity
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The Multifaceted Roles of IRE1 Are Unfolding

Wednesday, 09 March 2022 by Bellbrook Labs
IRE1 Proteins in ER
IRE1 (Inositol-Requiring Enzyme 1) is one of three resident transmembrane endoplasmic reticulum (ER) proteins that sense and signal distress from improper protein synthesis and conformation. (While IRE1 alpha is almost universally expressed and IRE1 beta is confined to the gut, both will be conflated as IRE1 here.)  Secreted and transmembrane proteins are primarily produced in
Assay Development Servicesdrug discovery servicesIRE1Lead Discovery Services
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  • Published in Emerging Targets, Innate Immunity
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MAPK1, An Elusive Regulator of Innate Immunity

Wednesday, 23 February 2022 by Bellbrook Labs
Researcher working on MAPK1 pathway
Mitogen-Activated Protein Kinases (MAPKs) and MAPK Signaling Cascade Mitogen-activated protein kinases (MAPKs) are Ser/Thr kinases involved in converting extracellular signals to a large spectrum of fundamental cellular processes such as apoptosis, cell division, metabolism survival, etc. This signaling cascade is known as the MAPK pathway. MAPKs are highly conserved among eukaryotes, which mirrors its indispensable
Lead Discovery ServicesMAPK1Transcreener ADP Kinase Assay
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  • Published in HTS Assays, Innate Immunity
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Five Considerations When Choosing a Biochemical Assay Development Services CRO

Monday, 28 September 2020 by Bellbrook Labs
Assay Development Services - Two Scientists Working In the Lab
There are many options out there for choosing assay development services, and finding what you need can be a challenging endeavor. Here we outline five items to look for when searching for the CRO that is right for your project. To narrow things down a bit, this article will focus on biochemical assay development services
Assay Development Servicesdrug discovery servicesLead Discovery Services
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  • Published in Resources
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Newly Patented Aurora A Kinase Inhibitor a Promising Contender for Cancer Treatment

Wednesday, 15 November 2017 by Bellbrook Labs
Aurora A Kinase in Cancer Drug Development Aurora A Kinase, along with -B and -C, are members of a family of serine/threonine protein kinases that play critical roles in coordinating mitosis, including establishment of the mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. The enzyme’s role
Assay Development Servicesdrug discovery serviceskinase assayLead Discovery ServicesTranscreener ADP Kinase Assay
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  • Published in HTS Assays, News, Products, Success Stories
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Using the Transcreener® GDP Assay to Discern the Truth about Dynamin Inhibitors

Thursday, 19 October 2017 by Bellbrook Labs
Imagine viewing the plasma membrane of a cell from an interior perspective, with a front-row seat to the process by which substances enter the cell. Over in one corner, the plasma membrane begins to bulge inward, forming a sphere stretching toward you with a droplet-shaped neck on the opposite side that remains connected to the
Assay Development Servicesdrug discovery servicesLead Discovery ServicesTranscreener GDP Assay
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  • Published in HTS Assays, News, Products, Success Stories
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New Posters from DOT 2017

Friday, 29 September 2017 by Bellbrook Labs
Poster Presentations A Homogenous, High Throughput Assay to Measure Guanine Nucleotide Exchange Factor Activity Using Transcreener® GDP Assay Guanine nucleotide exchange factors (GEFs) positively regulate Rho GTPases by accelerating GDP dissociation to allow formation of the active, GTP-bound complex. Development of inhibitors that specifically disrupt GEF action on a target Rho GTPase may be a
AptaFluor SAH Methyltransferase AssayAssay Development Servicesdrug discovery servicesLead Discovery ServicesTranscreener AMP/GMP AssayTranscreener cGAMP cGAS AssayTranscreener GDP Assay
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  • Published in HTS Assays, News
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Taking Up Residence: Using the Transcreener ADP Assay to Measure the Kinetics of Kinase Inhibitor Interactions

Wednesday, 30 August 2017 by Bellbrook Labs
Classically speaking, assays for interactions between drug molecules and their targets have measured binding affinity under equilibrium conditions. In drug discovery projects, it had long been assumed that carefully measuring IC50 (half-maximal inhibitory concentration), EC50 (effector concentration for half-maximal response), Kd  (equilibrium dissociation constant), and/or Ki (inhibition constant) would allow drug candidates to be prioritized
Assay Development Servicesdrug discovery serviceskinase assayLead Discovery ServicesResidence TimeTranscreener ADP Kinase Assay
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  • Published in HTS Assays, Uncategorized
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BellBrook Labs Launches Ultra-Sensitive Methyltransferase Assay to Accelerate Epigenetic Drug Discovery

Thursday, 10 August 2017 by Bellbrook Labs
Methyltransferases have become a major focus of drug discovery for cancer and other diseases driven by epigenetic factors.  BellBrook Labs’ new, ultra-sensitive AptaFluor™ SAH Methyltransferase Assay eliminates cost and sensitivity barriers that are slowing the discovery of methyltransferase inhibitors. New AptaFluor SAH Methyltransferase Assay Schematic BellBrook Labs announces the launch of their latest drug discovery
AptaFluor SAH Methyltransferase AssayAssay Development ServicesepigeneticsLead Discovery Servicesmethyltransferase
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  • Published in Epigenetics, News, Uncategorized
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EZH2 Methyltransferase Inhibitors Hold Promise for Combating Neuropathic Pain

Friday, 21 July 2017 by Bellbrook Labs
When people experience neuropathic pain, they often describe “pins and needles” sensations or burning, shooting, or stabbing pain that can be agonizing and difficult to bear. In some cases, neuropathic pain is so intense that the pressure of clothing or the weight of a bed sheet can cause misery. Chronic neuropathic pain can be caused
AptaFluor SAH Methyltransferase AssayAssay Development ServicesEPIGEN Methyltransferase AssayLead Discovery Servicesmethyltransferase
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  • Published in Emerging Targets, Epigenetics, HTS Assays
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