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Tag: MAPK14

Transcreener® ADP2 Assay Delivers Precise Measurement of Functional MAPK14 Residence Time

Monday, 01 May 2023 by Bellbrook Labs
Calculating MAPK14 Residence Time
Researchers at the University of Tubingen use Transcreener to uncover how residence time works on a molecular level with p38α MAPK Inhibitors – Many factors affect the effectiveness of ligand-substrate or drug-target interactions. Conformational docking and stearic considerations help inform optimal “fits.” Ligand moiety solubility, both in free and bound forms, is also a consideration
cancerinflammatory diseaseInnate Immunitykinase assayKinase Assay KitMAPK14neurodegenerative diseaseResidence TimeTranscreener ADP Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity, Products, Success Stories
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MAPK14 in Context

Wednesday, 13 April 2022 by Bellbrook Labs
Researcher Studying MAPK14
MAPK14 (or p38 alpha or SAPK2a) is a proline-directed serine/threonine kinase activated by environmental stress or inflammatory signaling. While it is a well-conserved eukaryotic gene in the mitogen-activated protein kinase family, MAPK14 doesn’t typically respond to mitogens. All the same, MAPK14 is critically involved in cardiac development, sex determination, innate and adaptive immunity, and cellular
MAPK14
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  • Published in Emerging Targets, Innate Immunity
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