Researchers Use Transcreener Assay to Identify New PDE5 Inhibitor

Researchers Identify PDE5 Inhibitor Using Transcreener Assay
Phosphodiesterase 5 (PDE5) is most familiar in connection to sildenafil (Viagra), a popular pharmaceutical PDE5 inhibitor. In response to nitric acid-activated soluble guanylyl cyclase production of cGMP, dimeric PDE5 binds and hydrolyzes cGMP in vascular smooth muscles cells, lung, kidney, brain, cardiac myocytes, and platelets to create 5′-GMP. This is accomplished by cGMP binding to
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Investigating RAB2 as a Vesicle Transporter & Autophagy Initiator

RAB2 Transports Membrane Bound Vesicles
RAB2 is part of the RAB family of small GTPases that regulate intracellular trafficking of membrane bound vesicles. It is highly conserved in eukaryotes, from C. elegans to humans. These GTPases influence the creation, movement, attachment, fusion, and destiny of vesicles originating in the endoplasmic reticulum (ER)/Golgi systems. Like other members of its family, RAB2
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Is PARP1 a Hero or Villain?

PARP1 as a Hero vs Villain
Not counting histones, PARP1 [Poly(ADP-ribose) Polymerase 1] is the most abundant nuclear protein in mammalian cells. While principally known for its role in various types of DNA repair, recent work expanded it’s repertoire to include genome stability maintenance, chromatin remodeling, DNA methylation/gene expression, cellular differentiation, and cell survival modulation via NAD+/ATP regulation.1 It performs Poly(ADP-ribosyl)ation
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SARM1 Forefronts Research into Major Neurological Diseases

SARM1 Causes Axonal Death
SARM1 [Sterile alpha & toll/interleukin receptor (TIR) motif-containing protein 1] consists of a N-terminal mitochondrial localization sequence (NLS), an autoinhibitory HEAT/armadillo (ARM) domain, two tandem sterile alpha motif domains (SAMs), and a C-terminal toll/interleukin receptor domain (TIR). It is a human toll like receptor (TLR) adaptor protein. TLR adaptors (MYD88, MAL, TRIF, & TRAM) usually
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