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Tag: Residence Time

A Guide to Measuring Drug-Target Residence Times with Biochemical Assays

Wednesday, 22 August 2018 by Bellbrook Labs
Residence Time Guide
Learn How to Determine Drug-Target Residence Times with Biochemical Assays in this Free Guide Drug-target residence time has become a critical component in the discovery of new therapeutics. BellBrook Labs has recently published a guide to help describe the use of a proven “jump-dilution” method along with BellBrook’s Transcreener Assay platform to help streamline efforts
Residence TimeTranscreener ADP Kinase AssayTranscreener AMP/GMP AssayTranscreener UDP Assay
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  • Published in HTS Assays
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Taking Up Residence: Using the Transcreener ADP Assay to Measure the Kinetics of Kinase Inhibitor Interactions

Wednesday, 30 August 2017 by Bellbrook Labs
Classically speaking, assays for interactions between drug molecules and their targets have measured binding affinity under equilibrium conditions. In drug discovery projects, it had long been assumed that carefully measuring IC50 (half-maximal inhibitory concentration), EC50 (effector concentration for half-maximal response), Kd  (equilibrium dissociation constant), and/or Ki (inhibition constant) would allow drug candidates to be prioritized
Assay Development Servicesdrug discovery serviceskinase assayLead Discovery ServicesResidence TimeTranscreener ADP Kinase Assay
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  • Published in HTS Assays, Uncategorized
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New Publication: HTS Method for Measuring Drug Residence Time

Tuesday, 25 April 2017 by Bellbrook Labs
View our latest publication, “A High-Throughput Method for Measuring Drug Residence Time Using the Transcreener® ADP2 Assay” in SLAS Discovery. Inhibitor residence times are increasingly being used to prioritize molecules early in lead discovery programs. Current methods for determining residence time are low-throughput or require the synthesis of labeled ligands. Our goal was to create
Assay Development Servicesdrug discovery servicesLead Discovery ServicesResidence TimeTranscreener ADP Kinase AssayTranscreener AMP/GMP AssayTranscreener GDP AssayTranscreener UDP Assay
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  • Published in Company, HTS Assays, News
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View Our Kinase Inhibitor Residence Time Webinar Anytime!

Monday, 11 May 2015 by Edna.Kunkel
Analysis of inhibitor residence times is increasingly being incorporated into lead development efforts because longer engagement with the target can result in improved efficacy, increased therapeutic window and reduced side effects. Though residence time can be determined using immobilized ligand methods such surface plasmon resonance, conjugation of drugs can affect their binding. In this webinar,
kinase assayResidence TimeTranscreener ADP Kinase Assay
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  • Published in HTS Assays, News
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