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Tag: Transcreener ADP Assay

Resolving the Many Roles of DHX36

Wednesday, 27 April 2022 by Bellbrook Labs
DHX36 RNA Helicase Unwinds G4 RNA Structures
While most researchers are familiar with canonical DNA structures, primarily B (but also even A or Z) DNA, an even more exotic form exerts a vast influence over nearly every aspect of nucleic acid function. In both DNA and RNA, tracts of guanine with at least four consecutive members can self-associate via Hoogsten base pairing
DHX36Helicase AssayTranscreener ADP Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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NSP14 – A Promising SARS-CoV-2 Therapeutic Target

Thursday, 20 January 2022 by Bellbrook Labs
NSP14 - Coronavirus Target
Non-Structural Proteins of Coronaviruses Coronaviruses have complex RNA-synthesizing machinery composed of many non-structural proteins (NSPs). While one-third of the viral genome encodes for structural proteins such as the spike, envelope, and nucleocapsid proteins, the remaining two-thirds encodes for NSPs. NSP genes are located within the 5’-region of the genome and studies have revealed that NSPs
Innate ImmunityNSP14Transcreener ADP Assay
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  • Published in Emerging Targets, Innate Immunity
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RIG-I: Important Sensor of Cytosolic RNA

Tuesday, 19 October 2021 by Bellbrook Labs
RIGI Cytosolic RNA Sensor
RIG-I-Like Receptors Retinoic acid-inducible gene 1 (RIG-I) is a cytoplasmic RNA helicase member of the RIG-I-like receptor (RLR) family of proteins. RIG-I is highly conserved within vertebrates. Structurally, RIG-I is comprised of three main functional domains – Caspase Activation and Recruitment Domain (CARD) for signal transduction, DExD/ H-box RNA helicase domain, and C-terminal domain for
Innate ImmunityRIG-ITranscreener ADP Assay
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  • Published in Emerging Targets, Innate Immunity
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