Resolving the Many Roles of DHX36
Wednesday, 27 April 2022
While most researchers are familiar with canonical DNA structures, primarily B (but also even A or Z) DNA, an even more exotic form exerts a vast influence over nearly every aspect of nucleic acid function. In both DNA and RNA, tracts of guanine with at least four consecutive members can self-associate via Hoogsten base pairing
- Published in Emerging Targets, HTS Assays, Innate Immunity
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NSP14 – A Promising SARS-CoV-2 Therapeutic Target
Thursday, 20 January 2022
Non-Structural Proteins of Coronaviruses Coronaviruses have complex RNA-synthesizing machinery composed of many non-structural proteins (NSPs). While one-third of the viral genome encodes for structural proteins such as the spike, envelope, and nucleocapsid proteins, the remaining two-thirds encodes for NSPs. NSP genes are located within the 5’-region of the genome and studies have revealed that NSPs
- Published in Emerging Targets, Innate Immunity
RIG-I: Important Sensor of Cytosolic RNA
Tuesday, 19 October 2021
RIG-I-Like Receptors Retinoic acid-inducible gene 1 (RIG-I) is a cytoplasmic RNA helicase member of the RIG-I-like receptor (RLR) family of proteins. RIG-I is highly conserved within vertebrates. Structurally, RIG-I is comprised of three main functional domains – Caspase Activation and Recruitment Domain (CARD) for signal transduction, DExD/ H-box RNA helicase domain, and C-terminal domain for
- Published in Emerging Targets, Innate Immunity