ABC Transporter ATPase Assay Helps Discover MsbA Inhibitors

ABC Transporter ATPase Assay Inhibitor
MsbA Inhibitors Help Fight Against Gram-Negative Bacteria As pathogens continue to wreak havoc on human health, new therapeutics are needed. HTS compatible assays such as the Transcreener ABC Transporter ATPase Assay help pave the way to establish new treatments. Gram-negative bacterial pathogens pose grave dangers in clinical and environmental settings alike. They include foodborne disease
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Using an ATPase Activity Assay for Drug Discovery

atpase activity assays for drug discovery
What are ATPases? Many people are familiar with the abbreviation ATP, which stands for the molecule adenosine triphosphate. ATP is the fascinating energy carrier of cellular processes and is involved in energy transfer in all living organisms. The energy released upon the chemical transformation from ATP to ADP is used in a myriad of biochemical
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Acetyl-CoA Carboxylase Inhibitors: Transcreener ADP Assay Powers Drug Detection Strategy

Acetyl-CoA Carboxylase Inhibitors
The impact of Acetyl-CoA carboxylases (ACCs) on eukaryotic metabolism and metabolic-related disease states is profound. ACCs catalyze the formation of malonyl-CoA by ATP-dependent carboxylation of acetyl-CoA. In humans, the two isoforms of ACC exhibit highly regulated, tissue-specific patterns of expression, with ACC1 being present in lipogenic tissues such as liver and adipose, and ACC2 being
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