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Tag: Transcreener ADP ATPase Assay

DDX1: A Versatile RNA Helicase

Tuesday, 18 April 2023 by Bellbrook Labs
DDX1 as a versatile RNA Helicase
DDX1 (Dead-Box Helicase 1) belongs to the DEAD-Box family of ATP-dependent RNA helicases, whose members are collectively involved in almost all aspects of RNA processing: from transcription to remodeling to degradation. They are named for the central Asp-Glu-Ala-Asp (DEAD) sequence they all possess. The 35 human DEAD-Box proteins comprise the largest family of helicases known.
ATPasecancerDDX1hyperlipidemiaInnate ImmunityTranscreener ADP ATPase Assay
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  • Published in Emerging Targets, Innate Immunity
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DDX41 as a Sensor, Suppressor, and Modulator

Thursday, 26 May 2022 by Bellbrook Labs
Scientist Studying DDX41
DDX41 [DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 41] is a cytosolic helicase sensor for dsDNA, DNA/RNA complexes, and cyclic dinucleotides (CDNs). Its N-terminal domain is responsible for translocation from the cytoplasm to the nucleus. Its DEAD domain, with its signature aspartate-glutamate-alanine-aspartate motif, is important for ATP-powered DNA/CDN detection and signaling. The remaining C-terminal domain functions as a
DDX41Transcreener ADP ATPase Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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NSP13 Inhibitors for the Potential Treatment of COVID-19

Monday, 14 June 2021 by Bellbrook Labs
NSP13 Inhibitors as COVID-19 Treatments
Could NSP13 be the target to help treat some respiratory infections such as SARS-CoV-2? Respiratory diseases caused by coronaviruses (CoVs) vary in symptoms, severity, and risk. Typically, symptoms are mild and known as the common cold, while others are more severe and lead to pneumonia or bronchitis, chest pains, and possibly death. SARS-CoV and MERS-CoV
Helicase AssayNSP13 InhibitorsTranscreener ADP ATPase Assay
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  • Published in Emerging Targets, HTS Assays, Innate Immunity
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Can DDX3 Inhibitors Lead to the Discovery of Antiviral Therapies?

Tuesday, 04 May 2021 by Bellbrook Labs
DDX3 inhibitors antiviral therapeutics
DDX3 inhibitors could unlock new treatments for viral diseases. The human immune response is extraordinary and incredibly complex. As the first line of defense against pathogens and foreign DNA, the innate response acts quickly. Viruses activate innate immunity as the host has proteins that recognize viral components. The innate immune response relies on several cell
DDX3Transcreener ADP ATPase Assay
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  • Published in Emerging Targets, HTS Assays
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Accelerating Discovery of Kinase Inhibitors Using an ADP Assay

Tuesday, 23 February 2021 by Bellbrook Labs
Researcher Using An ADP Assay
An ADP assay can be used to study the activity of enzymes that phosphorylate substrates leading to signaling events in the body. One of a variety of post-translational modifications, protein phosphorylation regulates a diverse group of cellular functions. In cancer, abnormal phosphorylation events often play a role in proliferation, survival, motility, metabolism, and angiogenesis.1 PI3K
adp assayTranscreener ADP ATPase AssayTranscreener ADP Kinase Assay
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  • Published in HTS Assays
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A Search for NLRP3 Inhibitors to Fight Autoimmune Disease

Wednesday, 08 July 2020 by Bellbrook Labs
Targeting Innate Immunity With NLRP3 Inhibitors
Can NLRP3 inhibitors help treat autoimmune disease? – The human immune response is complicated and we continue to discover pathways involved that add to the complexity. Different than the adaptive immune response, the innate response acts quickly and is considered the first line of defense against pathogens and foreign DNA. In order to do its
NLRP3 AssayNLRP3 InhibitorsTranscreener ADP ATPase Assay
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  • Published in Emerging Targets
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Researchers Validate Hsp70 Activity with the Transcreener ATPase Assay

Wednesday, 24 June 2020 by Bellbrook Labs
Researchers Studying Hsp70 Activity
Newly expressed human Hsp70 activity now being studied –  Heat shock protein 70 (Hsp70) is known for its upregulation during times of stress in order to maintain homeostasis. Like other heat shock proteins, Hsp70 is a chaperone protein that assists other proteins in correctly folding to become fully active molecules.  It binds to damaged, misfolded,
Hsp70 AssayTranscreener ADP ATPase Assay
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  • Published in HTS Assays, Success Stories
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ABC Transporter ATPase Assay Helps Discover MsbA Inhibitors

Tuesday, 16 July 2019 by Bellbrook Labs
ABC Transporter ATPase Assay Inhibitor
MsbA Inhibitors Help Fight Against Gram-Negative Bacteria As pathogens continue to wreak havoc on human health, new therapeutics are needed. HTS compatible assays such as the Transcreener ABC Transporter ATPase Assay help pave the way to establish new treatments. Gram-negative bacterial pathogens pose grave dangers in clinical and environmental settings alike. They include foodborne disease
ABC Transporter ATPase AssayATPase AssayTranscreener ADP ATPase AssayTranscreener ADP Kinase Assay
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  • Published in Emerging Targets, HTS Assays, Success Stories
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Using an ATPase Activity Assay for Drug Discovery

Wednesday, 06 March 2019 by Bellbrook Labs
atpase activity assays for drug discovery
What are ATPases? Many people are familiar with the abbreviation ATP, which stands for the molecule adenosine triphosphate. ATP is the fascinating energy carrier of cellular processes and is involved in energy transfer in all living organisms. A myriad of biochemical processes uses the energy released upon the chemical transformation from ATP to ADP. A
ATPase AssayTranscreener ADP ATPase Assay
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  • Published in HTS Assays
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Acetyl-CoA Carboxylase Inhibitors: Transcreener ADP Assay Powers Drug Detection Strategy

Wednesday, 19 September 2018 by Bellbrook Labs
Acetyl-CoA Carboxylase Inhibitors
The impact of Acetyl-CoA carboxylases (ACCs) on eukaryotic metabolism and metabolic-related disease states is profound. ACCs catalyze the formation of malonyl-CoA by ATP-dependent carboxylation of acetyl-CoA. In humans, the two isoforms of ACC exhibit highly regulated, tissue-specific patterns of expression, with ACC1 being present in lipogenic tissues such as liver and adipose, and ACC2 being
Acetyl-CoA CarboxylaseTranscreener ADP ATPase AssayTranscreener ADP Kinase Assay
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  • Published in HTS Assays, Products, Success Stories
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