MAPK1, An Elusive Regulator of Innate Immunity

Researcher working on MAPK1 pathway
Mitogen-Activated Protein Kinases (MAPKs) and MAPK Signaling Cascade Mitogen-activated protein kinases (MAPKs) are Ser/Thr kinases involved in converting extracellular signals to a large spectrum of fundamental cellular processes such as apoptosis, cell division, metabolism survival, etc. This signaling cascade is known as the MAPK pathway. MAPKs are highly conserved among eukaryotes, which mirrors its indispensable
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TYK2 Inhibition Finally Comes of Age

TYK2 Inhibition Discovery
Tyrosine kinase 2 (TYK2) was the first of the Janus family of non-receptor tyrosine kinases to be discovered. For three decades, the other members of this family, JAK1, JAK2, and JAK3, have dominated the research for inhibitors of autoimmune disease, largely because the effect upon them was more pronounced. They are called “Janus kinases” because
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The Double-Edged Sword in Cancer Pathogenesis – JNK1

JNK1 And Cancer Pathogenesis
Properties and Function of JNK1 c-Jun N-terminal kinase 1 (JNK1), also commonly known as Mitogen-Activated Protein Kinase 8 (MAPK8), is a member of the JNK subgroup of MAP kinases. JNK1 is encoded by the MAPK8 gene. MAP kinases form a superfamily of protein kinases that function by phosphorylating various protein substrates, including transcription factors, which
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Webinar: Targeting Kinases Involved in the Innate Immune Response

Abstract: Clinical trials continue to determine whether therapeutic modulation of kinases can be used to suppress the immune system in autoimmune diseases or stimulate for antiviral and cancer immunotherapy. The discovery and characterization of small molecule modulators have aided these efforts. The Transcreener ADP² Kinase Assay meets this need as it relies on direct ADP
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IKK Complex, NF-kB, and Inflammation – An Intricate Relationship

IKK Complex & Inflammation
Components of the IKK Complex The IκB kinase (IKK) complex consists of two catalytic subunits IKKα (IKK1) and IKKβ (IKK2), as well as a non-catalytic accessory protein IKKγ. IKKγ is also known as NF-κB essential modulator (NEMO). IKKα and IKKβ have high sequence homology and hence, are structurally similar. Both of those subunits possess phosphorylating
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JAK3 Inhibitors in the Treatment of Autoimmune Disease

JAK3 Inhibitors In the Fight Against Autoimmune Disease
Autoimmune disorders such as multiple sclerosis, psoriasis, and rheumatoid arthritis (RA), just to name a few, affect millions of people and have various contributing factors that lead to disease; some known and some unknown.   These disorders occur due to the immune system’s failure to discriminate between self vs. foreign entities. Janus Kinase 3 (JAK3) is
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Targeting Adenosine Kinase in the Fight Against Neurological Disorders

Targeting Adenosine Kinase In the Fight Against Neurological Disorders
Could targeting Adenosine Kinase help lead to treatments for neurological disorders and chronic pain? Adenosine, one of four nucleoside building blocks to DNA and RNA, has a shielding effect on a wide range of conditions, including inflammation, various forms of neuronal hyperexcitability, and/or toxicity, including hypoxia, seizures, and chronic pain. This cellular activity modulator brings
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Using a PKR Inhibitor Assay in the Fight Against Viruses

PKR Inhibitor Blog
Can a novel PKR inhibitor help lead to new treatments for viral infections? –  While the human immune response is astounding and works hard to keep us alive in the face of the many germs we encounter daily, it is exceedingly complex. Unlike the adaptive immune response, the innate response acts quickly. It is considered
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A Kinase Assay Kit to Interrogate Innate Immunity Targets

Performing a Kinase Assay Kit in a Lab
Kinases are essential players in cellular functions such as cell signaling, cellular transport, and protein regulation. For these reasons, many kinases are innate immunity targets. A kinase assay kit is ideal whether used for drug screening and dose-response measurements or detection when studying a particular cellular pathway. A universal ADP assay allows researchers to screen
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Accelerating Discovery of Kinase Inhibitors Using an ADP Assay

Researcher Using An ADP Assay
An ADP assay can be used to study the activity of enzymes that phosphorylate substrates leading to signaling events in the body. One of a variety of post-translational modifications, protein phosphorylation regulates a diverse group of cellular functions. In cancer, abnormal phosphorylation events often play a role in proliferation, survival, motility, metabolism, and angiogenesis.1 PI3K
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