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Tag: Transcreener ADP Kinase Assay

Uncovering IRAK4 Inhibitors with a Transcreener Kinase Assay Kit

Friday, 23 October 2020 by Bellbrook Labs
Lab IRAK4 Inhibitors Kinase Assay Kit
Genentech discovers IRAK4 inhibitors using the Transcreener Kinase Assay Kit – IRAK is also known as Interluekin-1 Receptor Associated Kinase. There are four different proteins within this group, including IRAK1, IRAK2, IRAK3, and IRAK4. Each of these mediates interaction with MyD88 and its associated adaptor proteins. IRAK1 and IRAK4 are active enzymes that exhibit kinase
IRAk1IRAK4Kinase Assay KitTranscreener ADP Kinase Assay
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Battling Autoimmune Disorders Using JAK1 Inhibitors

Wednesday, 12 August 2020 by Bellbrook Labs
JAK1 Inhibitors for Autoimmune Disease
Could specific JAK1 inhibitors lead to better treatments for autoimmune disease? – The human immune response is complex with numerous cellular pathways playing a role. And, when an abnormal immune response results from one’s own body, known as an autoimmune disorder – it adds to the complexity. While we often think of celiac disease, inflammatory
Autoimmune DiseaseInnate ImmunityJAK1 InhibitorsTranscreener ADP Kinase Assay
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  • Published in HTS Assays, News
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Transcreener Assay Used to Evaluate PI3K Inhibitors

Tuesday, 17 March 2020 by Bellbrook Labs
PI3K Inhibitors for Cancer Research
PI3K Inhibitors and Cancer – Although cancer is widespread, determining the culprit, as well as individual treatment, is challenging. A variety of cancer types exist with a multitude of contributors. Being the most common human genetic disease, a whole host of genes are involved. Some contribute to curbing cancer (tumor suppressor genes), while oncogenes promote
kinase assayPIK3Transcreener ADP Kinase Assay
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Transcreener ADP Assay Used to Discover RIPK1 Inhibitors

Tuesday, 18 February 2020 by Bellbrook Labs
RIPK1 Inhibitors Inflammatory disease treatment
Genentech discovers novel RIPK1 inhibitors – Like other serine/threonine protein kinases, receptor-interacting serine/threonine-protein kinase 1 (RIPK1) plays a role in several signaling pathways that keep us living healthy, functioning lives. RIPK1 is one of those enzymes’ that wears a variety of hats depending on what function needs attention. It contributes to cell death as well
kinase assayRIPK1 InhibitorsTranscreener ADP Kinase Assay
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TR-FRET Assays In Drug Discovery

Thursday, 06 February 2020 by Bellbrook Labs
TR-FRET Assays
Förster resonance energy transfer (FRET) technology and TR-FRET assays are used in laboratories globally for a variety of applications ranging from disease detection, to drug discovery, to monitoring genetic differences between individuals and populations. The brilliance of this technology is due to the sensitivity provided by the spectral overlap and the proximity of the acceptor
TR-FRET AssaysTranscreener ADP Kinase Assay
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  • Published in HTS Assays, Uncategorized
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Finding Inhibitors for a Cancer Target: CDK12 Activity Assays Accelerate the Search

Tuesday, 03 December 2019 by Bellbrook Labs
CDK12 Activity Assays Find Inhibitors Cancer Treatment
All systems within our bodies function by means of proteins. When these proteins aren’t made correctly, our body malfunctions.  The short explanation: DNA is at the fabric of forming a functional protein; genes (made of DNA) get transcribed and then translated to become proteins. During this complex process, genes are not always correctly transcribed and
CDK12 Activity Assayskinase assayTranscreener ADP Kinase Assay
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  • Published in Emerging Targets, HTS Assays
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Using TBK1 Inhibitors to Stop Cancer in Its Tracks

Tuesday, 29 October 2019 by Bellbrook Labs
Scientist Working on TBK1 Inhibitors for Cancer Research
TBK1 Inhibitors, Autoimmune Disorders, and Cancer – Inflammation is a crucial step within the immune response, helping our bodies eliminate disease. However, it can also be a burden where misregulation creates a variety of maladies including cancer. As inflammation persists, becoming chronic, the beneficial elements can be lost and disease occurs. It’s not just autoimmune
kinase assayTBK1 InhibitorsTranscreener ADP Kinase Assay
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  • Published in Emerging Targets
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How a Tyrosine Kinase Inhibitor Is Giving Hope to Lung Cancer Patients

Tuesday, 20 August 2019 by Bellbrook Labs
tyrosine kinase inhibitor lung cancer
According to the American Cancer Society, lung cancer is the leading cause of cancer death each year and accounts for approximately 13% of all new cases. The most common type being non-small cell lung cancer (NSCLC). Although smoking is the biggest contributor, other factors such as genetics and environmental pollutants contribute to lung cancer of
kinase assayTranscreener ADP Kinase Assaytyrosine kinase inhibitors
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  • Published in Emerging Targets
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ABC Transporter ATPase Assay Helps Discover MsbA Inhibitors

Tuesday, 16 July 2019 by Bellbrook Labs
ABC Transporter ATPase Assay Inhibitor
MsbA Inhibitors Help Fight Against Gram-Negative Bacteria As pathogens continue to wreak havoc on human health, new therapeutics are needed. HTS compatible assays such as the Transcreener ABC Transporter ATPase Assay help pave the way to establish new treatments. Gram-negative bacterial pathogens pose grave dangers in clinical and environmental settings alike. They include foodborne disease
ABC Transporter ATPase AssayATPase AssayTranscreener ADP ATPase AssayTranscreener ADP Kinase Assay
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  • Published in Emerging Targets, HTS Assays, Success Stories
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Novartis Uses Lipid Kinase Assay in a Quest for a PI4K Inhibitor

Tuesday, 25 June 2019 by Bellbrook Labs
Lipid Kinase Assay PI4K Inhibitor
Did you know that diarrhea is the second leading cause of death globally among children under the age of 5?1 Perhaps you have heard of one of the many diarrheal diseases such as cryptosporidiosis caused by a parasite called Cryptosporidium. Many people in the US might associate swimming pools with outbreaks of cryptosporidiosis due to
Lipid Kinase AssayPI4K Activity AssayTranscreener ADP Kinase Assay
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