RAF1 & Immunity: A Future Model For Cancer Research?
Tuesday, 28 June 2022
RAF1, also known as c-Raf, is a member of the Raf family of ubiquitous serine/threonine kinases that regulate several critical biological processes, such as proliferation, differentiation, apoptosis, and metabolism. It functions as an activator of the mitogen-activated protein kinase (MAPK)/ ERK kinase (MEK) signaling pathway and a key effector of the small G protein Ras.
- Published in Emerging Targets, Innate Immunity
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MAPK1, An Elusive Regulator of Innate Immunity
Wednesday, 23 February 2022
Mitogen-Activated Protein Kinases (MAPKs) and MAPK Signaling Cascade Mitogen-activated protein kinases (MAPKs) are Ser/Thr kinases involved in converting extracellular signals to a large spectrum of fundamental cellular processes such as apoptosis, cell division, metabolism survival, etc. This signaling cascade is known as the MAPK pathway. MAPKs are highly conserved among eukaryotes, which mirrors its indispensable
- Published in HTS Assays, Innate Immunity
TYK2 Inhibition Finally Comes of Age
Tuesday, 01 February 2022
Tyrosine kinase 2 (TYK2) was the first of the Janus family of non-receptor tyrosine kinases to be discovered. For three decades, the other members of this family, JAK1, JAK2, and JAK3, have dominated the research for inhibitors of autoimmune disease, largely because the effect upon them was more pronounced. They are called “Janus kinases” because
- Published in Emerging Targets, Innate Immunity
The Double-Edged Sword in Cancer Pathogenesis – JNK1
Wednesday, 03 November 2021
Properties and Function of JNK1 c-Jun N-terminal kinase 1 (JNK1), also commonly known as Mitogen-Activated Protein Kinase 8 (MAPK8), is a member of the JNK subgroup of MAP kinases. JNK1 is encoded by the MAPK8 gene. MAP kinases form a superfamily of protein kinases that function by phosphorylating various protein substrates, including transcription factors, which
- Published in Emerging Targets, HTS Assays, Innate Immunity
Webinar: Targeting Kinases Involved in the Innate Immune Response
Wednesday, 13 October 2021
Abstract: Clinical trials continue to determine whether therapeutic modulation of kinases can be used to suppress the immune system in autoimmune diseases or stimulate for antiviral and cancer immunotherapy. The discovery and characterization of small molecule modulators have aided these efforts. The Transcreener ADP² Kinase Assay meets this need as it relies on direct ADP
- Published in Emerging Targets, HTS Assays, Innate Immunity
IKK Complex, NF-kB, and Inflammation – An Intricate Relationship
Tuesday, 07 September 2021
Components of the IKK Complex The IκB kinase (IKK) complex consists of two catalytic subunits IKKα (IKK1) and IKKβ (IKK2), as well as a non-catalytic accessory protein IKKγ. IKKγ is also known as NF-κB essential modulator (NEMO). IKKα and IKKβ have high sequence homology and hence, are structurally similar. Both of those subunits possess phosphorylating
- Published in Emerging Targets, Innate Immunity
JAK3 Inhibitors in the Treatment of Autoimmune Disease
Tuesday, 27 July 2021
Autoimmune disorders such as multiple sclerosis, psoriasis, and rheumatoid arthritis (RA), just to name a few, affect millions of people and have various contributing factors that lead to disease; some known and some unknown. These disorders occur due to the immune system’s failure to discriminate between self vs. foreign entities. Janus Kinase 3 (JAK3) is
- Published in Innate Immunity, Products
Targeting Adenosine Kinase in the Fight Against Neurological Disorders
Monday, 28 June 2021
Could targeting Adenosine Kinase help lead to treatments for neurological disorders and chronic pain? Adenosine, one of four nucleoside building blocks to DNA and RNA, has a shielding effect on a wide range of conditions, including inflammation, various forms of neuronal hyperexcitability, and/or toxicity, including hypoxia, seizures, and chronic pain. This cellular activity modulator brings
- Published in Emerging Targets, Innate Immunity, Neurodegenerative Diseases
Using a PKR Inhibitor Assay in the Fight Against Viruses
Tuesday, 01 June 2021
Can a novel PKR inhibitor help lead to new treatments for viral infections? – While the human immune response is astounding and works hard to keep us alive in the face of the many germs we encounter daily, it is exceedingly complex. Unlike the adaptive immune response, the innate response acts quickly. It is considered
- Published in Emerging Targets, HTS Assays, Innate Immunity
A Kinase Assay Kit to Interrogate Innate Immunity Targets
Thursday, 15 April 2021
Kinases are essential players in cellular functions such as cell signaling, cellular transport, and protein regulation. For these reasons, many kinases are innate immunity targets. A kinase assay kit is ideal whether used for drug screening and dose-response measurements or detection when studying a particular cellular pathway. A universal ADP assay allows researchers to screen
- Published in HTS Assays, Products