Battling Autoimmune Disorders Using JAK1 Inhibitors
Wednesday, 12 August 2020
Could specific JAK1 inhibitors lead to better treatments for autoimmune disease? – The human immune response is complex with numerous cellular pathways playing a role. And, when an abnormal immune response results from one’s own body, known as an autoimmune disorder – it adds to the complexity. While we often think of celiac disease, inflammatory
- Published in HTS Assays, News
TR-FRET Assays In Drug Discovery
Thursday, 06 February 2020
Förster resonance energy transfer (FRET) technology and TR-FRET assays are used in laboratories globally for a variety of applications ranging from disease detection, to drug discovery, to monitoring genetic differences between individuals and populations. The brilliance of this technology is due to the sensitivity provided by the spectral overlap and the proximity of the acceptor
- Published in HTS Assays, Uncategorized
Finding Inhibitors for a Cancer Target: CDK12 Activity Assays Accelerate the Search
Tuesday, 03 December 2019
All systems within our bodies function by means of proteins. When these proteins aren’t made correctly, our body malfunctions. The short explanation: DNA is at the fabric of forming a functional protein; genes (made of DNA) get transcribed and then translated to become proteins. During this complex process, genes are not always correctly transcribed and
- Published in Emerging Targets, HTS Assays
Using TBK1 Inhibitors to Stop Cancer in Its Tracks
Tuesday, 29 October 2019
TBK1 Inhibitors, Autoimmune Disorders, and Cancer – Inflammation is a crucial step within the immune response, helping our bodies eliminate disease. However, it can also be a burden where misregulation creates a variety of maladies including cancer. As inflammation persists, becoming chronic, the beneficial elements can be lost and disease occurs. It’s not just autoimmune
- Published in Emerging Targets
How a Tyrosine Kinase Inhibitor Is Giving Hope to Lung Cancer Patients
Tuesday, 20 August 2019
According to the American Cancer Society, lung cancer is the leading cause of cancer death each year and accounts for approximately 13% of all new cases. The most common type being non-small cell lung cancer (NSCLC). Although smoking is the biggest contributor, other factors such as genetics and environmental pollutants contribute to lung cancer of
- Published in Emerging Targets