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Tag: Transcreener AMP/GMP Assay

New Publication by the Scientists at BellBrook Labs – Development of a High-Throughput Assay to Identify Inhibitors of ENPP1

Thursday, 11 February 2021 by Bellbrook Labs
Inhibitors of ENPP1 SLAS Discovery
BellBrook scientist Meera Kumar and Robert Lowery were recently published in SLAS Discovery for their work entitled Development of a High-Throughput Assay to Identify Inhibitors of ENPP1. Ectonucleotide pyrophosphatase/phosphodiesterase 1 or ENNP1 has recently become a target for cancer immunotherapy. ENNP1 hydrolyzes nucleotides such as cGAMP and ATP. Cytosolic DNA is a trigger for the
ENPP1 AssayTranscreener AMP/GMP Assay
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  • Published in Emerging Targets, HTS Assays, News
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Using a Universal GMP Assay for PDE Research

Thursday, 28 January 2021 by Bellbrook Labs
GMP Assay for PDE Inhibitor Discovery
A universal GMP assay to aid in PDE research and potential COVID-19 disruption. – Phosphodiesterase enzymes (PDEs) modulate pathways throughout the body. Since unregulated PDEs contribute to disease in many cases, it makes sense therapies that inhibit these enzymes have the potential to treat several different ailments. These include cardiovascular and respiratory issues, diabetes, fibrotic
gmp assayPDE InhibitorsPhosphodiesterase AssayTranscreener AMP/GMP Assay
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  • Published in HTS Assays, Uncategorized
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ST6GAL1 Drug Discovery to Combat Cancer

Wednesday, 08 January 2020 by Bellbrook Labs
ST6GAL1 Drug Discovery
The number of cancer hallmarks has increased as the knowledge and understanding of the disease progress. As many of us already know, the basic characteristic is a mutation that causes uncontrollable cell growth causing a tumor. Cancer is truly a multi-step development that enables cells to survive, proliferate and metastasize. Other hallmarks of the disease
Sialyltransferase AssayST6GAL1Transcreener AMP/GMP Assay
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  • Published in Emerging Targets, HTS Assays
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Helping Fight Ovarian Cancer with ST3GAL1 Inhibitors

Monday, 11 November 2019 by Bellbrook Labs
Fighting Ovarian Cancer ST3GAL1 Inhibitors
Important functions such as cell–cell recognition, protein targeting, and cell adhesion taking place in the human body get carried out through a process known as sialylation. Sialylation is a common reaction that is catalyzed by a sialyltransferase (ST) enzyme with the goal of adding a sialic acid (monosaccharide) to a growing oligosaccharide forming a glycolipid
ST3GAL1 InhibitorsTranscreener AMP/GMP AssayTranscreener CMP Assay
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  • Published in HTS Assays
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ENPP1 Inhibitors, Assays, and Innate Immunity

Wednesday, 16 October 2019 by Bellbrook Labs
ENPP1 Inhibitors Improve Innate Immunity
The human immune response is incredible. Unlike the adaptive immune response, the innate response acts quickly and is considered the first line of defense against pathogens and foreign DNA such as tumor cells. To be effective, the innate immune response relies on several cell types and a multitude of proteins such as interferons (INFs). This
ENPP1 AssayTranscreener AMP/GMP Assay
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  • Published in Emerging Targets
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How A PDE Activity Assay Might Help Find New Treatments for Individuals Suffering from Heart Disease

Tuesday, 06 August 2019 by Bellbrook Labs
PDE Activity Assay Heart Disease
Heart Disease: The Role of PDEs and a PDE Activity Assay Heart disease is often misunderstood due to confusion with terminology and the different types of heart disease that exist. While a heart attack can occur quickly, heart failure is a slower progression where the heart weakens over time. One thing is certain; heart disease
PDE Activity AssayPhosphodiesterase AssayTranscreener AMP/GMP Assay
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  • Published in HTS Assays
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Ubiquitin Ligase Assay: A Handy Tool for Drug Discovery

Wednesday, 29 May 2019 by Bellbrook Labs
Ubiquitin Ligase Assay Tool for Drug Discovery
Can one cellular pathway contribute to many different types of disease? Research has shown that Ubiquitination is one such pathway due to its role in the regulation of protein degradation within homeostasis, cell cycle, and DNA repair. It has been established that at least the following diseases are among those affected from alterations in this
Transcreener AMP/GMP Assayubiquitin ligase assay
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  • Published in Emerging Targets, HTS Assays
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Could an Inhibitor of Phosphodiesterase Activity be a Treatment for Alzheimer’s?

Tuesday, 14 May 2019 by Bellbrook Labs
As we continue to increase our lifespan, diseases such as Alzheimer’s will subsequently persist to develop. With up to 4.5 million Americans currently affected, there’s a strong desire to find a cure or at the very least some relief from the symptoms.¹   Neurodegeneration derived memory loss is the most common and perhaps the most devastating result
Phosphodiesterase AssayTranscreener AMP/GMP Assay
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  • Published in Emerging Targets, HTS Assays
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Immuno-Oncology Drug Discovery: A CD39 Activity Assay for a Promising Target

Thursday, 02 May 2019 by Bellbrook Labs
Cancer Cell T Cell CD39 Activity Assay
What comes to mind when you think of immunotherapy? The immune system, with all its complexities, contributes to numerous diseases that affect our society. It’s no wonder scientists scramble to find therapies that will either suppress (suppression immunotherapies) or activate (activation immunotherapies) an immune response. Immunotherapy isn’t only used for autoimmune diseases or infectious disease.
cd39 assayTranscreenerTranscreener AMP/GMP Assay
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  • Published in Emerging Targets, HTS Assays
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Visit With BellBrook Labs at Discovery On Target 2018

Tuesday, 04 September 2018 by Bellbrook Labs
Discovery on Target 2018
BellBrook Labs will exhibit and present posters at the upcoming Discovery on Target conference in Boston, MA. At the event BellBrook will demonstrate applications for its suite of high throughput screening tools, including residence time determination, methyltransferase activity measurement, studying ectonucleotidase enzymes, screening for kinase inhibitors, and more! Discovery on Target 2018 Sheraton Boston Hotel
AptaFluor SAH Methyltransferase AssayTranscreener ADP Kinase AssayTranscreener AMP/GMP Assay
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  • Published in News
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Recent Posts

  • Researcher Using An ADP Assay

    Accelerating Discovery of Kinase Inhibitors Using an ADP Assay

    An ADP assay can be used to study the activity ...
  • Inhibitors of ENPP1 SLAS Discovery

    New Publication by the Scientists at BellBrook Labs – Development of a High-Throughput Assay to Identify Inhibitors of ENPP1

    BellBrook scientist Meera Kumar and Robert Lowe...
  • GMP Assay for PDE Inhibitor Discovery

    Using a Universal GMP Assay for PDE Research

    A universal GMP assay to aid in PDE research an...
  • SLAS 2021

    Join Us for SLAS 2021 Virtual Conference

    BellBrook Labs will be exhibiting at SLAS 2021,...
  • New cGAS TR-FRET Assay

    New TR-FRET Readout Now Available with the Transcreener cGAMP cGAS Assay

    Launched in November 2019, the Transcreener cGA...

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